KR890014743A - 성장인자 활성을 가진 신규의 폴리펩티드 및 그 폴리펩티드를 코드화한 아미노산 배열 - Google Patents
성장인자 활성을 가진 신규의 폴리펩티드 및 그 폴리펩티드를 코드화한 아미노산 배열 Download PDFInfo
- Publication number
- KR890014743A KR890014743A KR1019890003761A KR890003761A KR890014743A KR 890014743 A KR890014743 A KR 890014743A KR 1019890003761 A KR1019890003761 A KR 1019890003761A KR 890003761 A KR890003761 A KR 890003761A KR 890014743 A KR890014743 A KR 890014743A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- region
- polypeptide
- sequence
- dna sequence
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 39
- 239000003102 growth factor Substances 0.000 title claims description 8
- 229920001184 polypeptide Polymers 0.000 title claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 38
- 125000003275 alpha amino acid group Chemical group 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 claims description 83
- 235000001014 amino acid Nutrition 0.000 claims description 50
- 108010079105 Shope fibroma virus growth factor Proteins 0.000 claims description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 39
- 239000003446 ligand Substances 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 24
- 102000001301 EGF receptor Human genes 0.000 claims 13
- 108060006698 EGF receptor Proteins 0.000 claims 13
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 9
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 8
- 230000002103 transcriptional effect Effects 0.000 claims 7
- 101800003344 Vaccinia growth factor Proteins 0.000 claims 6
- 101800001863 Variola growth factor Proteins 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 4
- 230000014621 translational initiation Effects 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 102100037571 Neurosecretory protein VGF Human genes 0.000 claims 2
- 101150104425 T4 gene Proteins 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical group C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 102000007299 Amphiregulin Human genes 0.000 claims 1
- 108010033760 Amphiregulin Proteins 0.000 claims 1
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 101000708699 Escherichia phage lambda Antitermination protein N Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102100020880 Kit ligand Human genes 0.000 claims 1
- 101710177504 Kit ligand Proteins 0.000 claims 1
- 241001138401 Kluyveromyces lactis Species 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- -1 ampyregulin Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000001784 detoxification Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 210000004898 n-terminal fragment Anatomy 0.000 claims 1
- 108010083127 phage repressor proteins Proteins 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17265388A | 1988-03-24 | 1988-03-24 | |
| US172,653 | 1988-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890014743A true KR890014743A (ko) | 1989-10-25 |
Family
ID=22628611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890003761A KR890014743A (ko) | 1988-03-24 | 1989-03-24 | 성장인자 활성을 가진 신규의 폴리펩티드 및 그 폴리펩티드를 코드화한 아미노산 배열 |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPH0279981A (es) |
| KR (1) | KR890014743A (es) |
| AU (2) | AU3169589A (es) |
| BE (1) | BE1004202A5 (es) |
| CH (1) | CH681081A5 (es) |
| DE (1) | DE3910084A1 (es) |
| DK (1) | DK146789A (es) |
| ES (1) | ES2013408A6 (es) |
| FI (1) | FI891308A (es) |
| FR (1) | FR2632321A1 (es) |
| GB (1) | GB2219799B (es) |
| GR (1) | GR1000876B (es) |
| HU (1) | HUT50501A (es) |
| IE (1) | IE890950L (es) |
| IL (1) | IL89673A0 (es) |
| IT (1) | IT1234961B (es) |
| LU (1) | LU87489A1 (es) |
| NL (1) | NL8900724A (es) |
| NO (1) | NO891273D0 (es) |
| NZ (1) | NZ228427A (es) |
| PT (1) | PT90118B (es) |
| SE (1) | SE8901031L (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293785A3 (en) * | 1987-05-29 | 1990-05-02 | Oncogen Limited Partnership | Cloning and expression of simian transforming growth factor-ss1 |
| EP0444961A1 (en) * | 1990-03-02 | 1991-09-04 | Bristol-Myers Squibb Company | Her3: A novel EGF receptor homolog |
| EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
| US6852506B1 (en) | 1996-04-10 | 2005-02-08 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
| WO1997038002A1 (en) * | 1996-04-10 | 1997-10-16 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0108132A1 (en) * | 1982-05-06 | 1984-05-16 | Applied Molecular Genetics Inc. | The manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
| JPS6028994A (ja) * | 1983-07-08 | 1985-02-14 | Wakunaga Seiyaku Kk | 〔２１―ロイシン〕ヒトウロガストロン |
| WO1985002198A1 (en) * | 1983-11-01 | 1985-05-23 | Amgen | Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides |
| JP2554459B2 (ja) * | 1984-07-02 | 1996-11-13 | アース製薬 株式会社 | β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体 |
| JPS62501071A (ja) * | 1984-10-30 | 1987-04-30 | オンコゲン | 成長因子活性を有する新規なポリペプチド及び該ポリペプチドをコ−ドする核酸配列 |
| GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
| US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
| GB2210618B (en) * | 1987-10-08 | 1991-10-16 | British Bio Technology | Synthetic egf gene |
| EP0372005A4 (en) * | 1987-10-30 | 1990-06-26 | Oncogen | EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS. |
| EP0314184B1 (en) * | 1987-10-30 | 1995-12-13 | Bristol-Myers Squibb Company | Expression plasmids |
-
1989
- 1989-03-20 IL IL89673A patent/IL89673A0/xx unknown
- 1989-03-20 FI FI891308A patent/FI891308A/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228427A patent/NZ228427A/xx unknown
- 1989-03-22 NO NO891273A patent/NO891273D0/no unknown
- 1989-03-22 DK DK146789A patent/DK146789A/da not_active Application Discontinuation
- 1989-03-22 ES ES8901049A patent/ES2013408A6/es not_active Expired - Lifetime
- 1989-03-22 SE SE8901031A patent/SE8901031L/xx not_active Application Discontinuation
- 1989-03-23 IE IE890950A patent/IE890950L/xx unknown
- 1989-03-23 AU AU31695/89A patent/AU3169589A/en not_active Abandoned
- 1989-03-23 NL NL8900724A patent/NL8900724A/nl not_active Application Discontinuation
- 1989-03-23 GR GR890100185A patent/GR1000876B/el unknown
- 1989-03-23 GB GB8906758A patent/GB2219799B/en not_active Expired - Fee Related
- 1989-03-24 IT IT8919917A patent/IT1234961B/it active
- 1989-03-24 HU HU891515A patent/HUT50501A/hu unknown
- 1989-03-24 JP JP1073723A patent/JPH0279981A/ja active Pending
- 1989-03-24 BE BE8900329A patent/BE1004202A5/fr not_active IP Right Cessation
- 1989-03-24 KR KR1019890003761A patent/KR890014743A/ko not_active Application Discontinuation
- 1989-03-24 LU LU87489A patent/LU87489A1/xx unknown
- 1989-03-24 FR FR8903952A patent/FR2632321A1/fr not_active Withdrawn
- 1989-03-27 PT PT90118A patent/PT90118B/pt active IP Right Grant
- 1989-03-28 DE DE3910084A patent/DE3910084A1/de not_active Withdrawn
- 1989-03-28 CH CH1114/89A patent/CH681081A5/de not_active IP Right Cessation
-
1992
- 1992-12-04 AU AU29904/92A patent/AU2990492A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2013408A6 (es) | 1990-05-01 |
| NO891273D0 (no) | 1989-03-22 |
| NL8900724A (nl) | 1989-10-16 |
| PT90118B (pt) | 1994-07-29 |
| FI891308A0 (fi) | 1989-03-20 |
| LU87489A1 (fr) | 1989-10-26 |
| HUT50501A (en) | 1990-02-28 |
| SE8901031L (sv) | 1989-09-25 |
| GB2219799B (en) | 1992-10-14 |
| GB8906758D0 (en) | 1989-05-10 |
| GR890100185A (en) | 1990-01-19 |
| SE8901031D0 (sv) | 1989-03-22 |
| DK146789D0 (da) | 1989-03-22 |
| NZ228427A (en) | 1993-03-26 |
| AU3169589A (en) | 1989-09-28 |
| JPH0279981A (ja) | 1990-03-20 |
| GB2219799A (en) | 1989-12-20 |
| IE890950L (en) | 1989-09-24 |
| GR1000876B (el) | 1993-03-16 |
| FI891308A (fi) | 1989-09-25 |
| IL89673A0 (en) | 1989-09-28 |
| DK146789A (da) | 1989-09-25 |
| AU2990492A (en) | 1993-03-04 |
| CH681081A5 (es) | 1993-01-15 |
| IT8919917A0 (it) | 1989-03-24 |
| FR2632321A1 (fr) | 1989-12-08 |
| IT1234961B (it) | 1992-06-09 |
| BE1004202A5 (fr) | 1992-10-13 |
| PT90118A (pt) | 1989-11-10 |
| DE3910084A1 (de) | 1989-11-16 |
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