KR890012647A - 페리오퍼레이티브 치료에 유용한 4-치환 이미다졸 유도체 - Google Patents

페리오퍼레이티브 치료에 유용한 4-치환 이미다졸 유도체 Download PDF

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Publication number
KR890012647A
KR890012647A KR1019890002361A KR890002361A KR890012647A KR 890012647 A KR890012647 A KR 890012647A KR 1019890002361 A KR1019890002361 A KR 1019890002361A KR 890002361 A KR890002361 A KR 890002361A KR 890012647 A KR890012647 A KR 890012647A
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KR
South Korea
Prior art keywords
imidazole derivatives
derivatives useful
substituted imidazole
dimethylphenyl
imidazole
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KR1019890002361A
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English (en)
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KR0136790B1 (ko
Inventor
메이즈 멀빈
슈나이닌 미커
Original Assignee
하이키 오얀페래, 하칸 코트카
파르모스-이티마 오이
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Application filed by 하이키 오얀페래, 하칸 코트카, 파르모스-이티마 오이 filed Critical 하이키 오얀페래, 하칸 코트카
Publication of KR890012647A publication Critical patent/KR890012647A/ko
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Publication of KR0136790B1 publication Critical patent/KR0136790B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음.

Description

페리오퍼레이티브 치료에 유용한 4-치환 이미다졸 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 수술하는 동안 스트레스가 많은 자극에 대한 자율 신경계의 반응을 감소시키기 위하여 포유동물의 페리오퍼레이티브(perio-perative) 처리용 약제의 제조에 사용하기 위한, 라세미 또는 덱스트로 4-[1-(2,3-디메틸페닐)에틸]-1H-이미다졸 또는 이들의 비독성 제약학적으로 허용가능한 염인 화합물.
  2. 제1항에 있어서, 덱스트로 4-[1-(2,3-디메틸페닐)에틸]-1H-이미다졸 또는 이드르이 비-독성 제약학적으로 허용가능한 염인 화합물.
  3. 제1항 또는 제2항에 있어서, 약제가 국부 또는 일반적 마취가 있거나 없는 수술전에 불안해소 진통성예비 약제로서 사용하기 위한 화합물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 약제가 마취의 효과를 제공하여 마취제 요구량을 감소시키는 진정제로서 수술전에 사용하기 위한 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개한 것임.
KR1019890002361A 1988-02-29 1989-02-27 페리오퍼레이티브 치료에 유용한 4-치환 이미다졸 유도체를 포함하는 약제 KR0136790B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI8804683 1988-02-29
GB8804683A GB2215206B (en) 1988-02-29 1988-02-29 4-substituted imidazole derivatives useful in perioperative care

Publications (2)

Publication Number Publication Date
KR890012647A true KR890012647A (ko) 1989-09-18
KR0136790B1 KR0136790B1 (ko) 1998-04-25

Family

ID=10632543

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890002361A KR0136790B1 (ko) 1988-02-29 1989-02-27 페리오퍼레이티브 치료에 유용한 4-치환 이미다졸 유도체를 포함하는 약제

Country Status (13)

Country Link
EP (1) EP0331374B1 (ko)
JP (1) JP2856410B2 (ko)
KR (1) KR0136790B1 (ko)
AT (1) ATE101514T1 (ko)
AU (1) AU611262B2 (ko)
CA (1) CA1338556C (ko)
DE (1) DE68913054T2 (ko)
DK (1) DK175282B1 (ko)
GB (1) GB2215206B (ko)
HU (1) HU202751B (ko)
IE (1) IE60538B1 (ko)
NZ (1) NZ228125A (ko)
ZA (1) ZA891493B (ko)

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GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2281206A (en) * 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
WO1997024354A1 (fr) * 1995-12-28 1997-07-10 The Procter & Gamble Company 6-r-1,3,4-thiadiazine-2-amines substitues, leur utilisation en qualite d'agents anesthesiques, cardio-vasculaires et hypometaboliques, et composition pharmaceutique les contenant
WO1997024353A1 (fr) * 1995-12-28 1997-07-10 The Procter & Gamble Company 6-h-1,3,4-thiadiazine-2-amines substitues, leur utilisation en qualite d'agents anesthesiques, cardio-vasculaires et hypometaboliques, et composition pharmaceutique les contenant
ES2172606T3 (es) * 1995-12-28 2002-10-01 N T Predpr Ligand Obschestvo S 6-h-1,3,4-tiadiazin-2-aminas, su uso como agentes anestesicos, cardiovasculares e hipometabolicos, y una composicion farmaceutica que las contiene.
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
JP2009524616A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ疾患のための４−イミダゾール誘導体の使用
AU2007312390B2 (en) 2006-10-19 2013-03-28 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
JP5064511B2 (ja) 2006-11-02 2012-10-31 エフ．ホフマン−ラ ロシュ アーゲー 痕跡アミン関連受容体調節剤としての置換２−イミダゾール
KR101134226B1 (ko) 2006-11-16 2012-04-10 에프. 호프만-라 로슈 아게 치환된 4-이미다졸
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CA2676944C (en) 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
EP2173720A2 (en) 2007-07-02 2010-04-14 F. Hoffmann-Roche AG 2-imidazolines having a good affinity to the trace amine associated receptors (taars)
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US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
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WO2013078151A1 (en) 2011-11-21 2013-05-30 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
EP3054930B1 (en) 2013-10-07 2020-12-02 Teikoku Pharma USA, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
CN105764494A (zh) 2013-10-07 2016-07-13 帝国制药美国公司 右旋美托咪啶经皮递送装置及其使用方法
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Also Published As

Publication number Publication date
GB2215206B (en) 1991-07-03
ATE101514T1 (de) 1994-03-15
GB8804683D0 (en) 1988-03-30
DE68913054D1 (de) 1994-03-24
JP2856410B2 (ja) 1999-02-10
EP0331374B1 (en) 1994-02-16
GB2215206A (en) 1989-09-20
AU3027289A (en) 1989-08-31
EP0331374A3 (en) 1990-10-10
CA1338556C (en) 1996-08-27
AU611262B2 (en) 1991-06-06
IE890639L (en) 1989-08-29
HUT51139A (en) 1990-04-28
DK46489A (da) 1989-08-30
EP0331374A2 (en) 1989-09-06
DK175282B1 (da) 2004-08-09
HU202751B (en) 1991-04-29
JPH01294623A (ja) 1989-11-28
KR0136790B1 (ko) 1998-04-25
ZA891493B (en) 1989-11-29
DE68913054T2 (de) 1994-07-07
IE60538B1 (en) 1994-07-27
DK46489D0 (da) 1989-02-02
NZ228125A (en) 1996-12-20

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