ATE101514T1 - Verwendung von 4-substituierten-imidazolderivaten in der perioperativen medikation. - Google Patents

Verwendung von 4-substituierten-imidazolderivaten in der perioperativen medikation.

Info

Publication number
ATE101514T1
ATE101514T1 AT89301866T AT89301866T ATE101514T1 AT E101514 T1 ATE101514 T1 AT E101514T1 AT 89301866 T AT89301866 T AT 89301866T AT 89301866 T AT89301866 T AT 89301866T AT E101514 T1 ATE101514 T1 AT E101514T1
Authority
AT
Austria
Prior art keywords
perioperative
medication
substituted
imidazole derivatives
imidazole
Prior art date
Application number
AT89301866T
Other languages
English (en)
Inventor
Mervyn Maze
Mika Scheinin
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Application granted granted Critical
Publication of ATE101514T1 publication Critical patent/ATE101514T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT89301866T 1988-02-29 1989-02-24 Verwendung von 4-substituierten-imidazolderivaten in der perioperativen medikation. ATE101514T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8804683A GB2215206B (en) 1988-02-29 1988-02-29 4-substituted imidazole derivatives useful in perioperative care
EP89301866A EP0331374B1 (de) 1988-02-29 1989-02-24 Verwendung von 4-substituierten-Imidazol-Derivaten in der perioperativen Medikation

Publications (1)

Publication Number Publication Date
ATE101514T1 true ATE101514T1 (de) 1994-03-15

Family

ID=10632543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89301866T ATE101514T1 (de) 1988-02-29 1989-02-24 Verwendung von 4-substituierten-imidazolderivaten in der perioperativen medikation.

Country Status (13)

Country Link
EP (1) EP0331374B1 (de)
JP (1) JP2856410B2 (de)
KR (1) KR0136790B1 (de)
AT (1) ATE101514T1 (de)
AU (1) AU611262B2 (de)
CA (1) CA1338556C (de)
DE (1) DE68913054T2 (de)
DK (1) DK175282B1 (de)
GB (1) GB2215206B (de)
HU (1) HU202751B (de)
IE (1) IE60538B1 (de)
NZ (1) NZ228125A (de)
ZA (1) ZA891493B (de)

Families Citing this family (31)

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FI894911A0 (fi) * 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2281206A (en) * 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
WO1997024353A1 (en) * 1995-12-28 1997-07-10 The Procter & Gamble Company Substituted 6-h-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
EP0877024B1 (de) * 1995-12-28 2002-02-20 Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju) Substituierte 6-h-1,3,4,-thiadiazin-2-amine, deren verwendung als anaesthetisierende, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
RU2157210C2 (ru) * 1995-12-28 2000-10-10 Проктер энд Гэмбл Компани Замещенные 6h-1,3,4-тиадиазин-2-амины, их применение в качестве анестезирующих, сердечно-сосудистых и гипометаболических средств и содержащие их фармацевтические композиции
EP0877026B1 (de) * 1995-12-28 2001-10-31 The Procter & Gamble Company Substituierte 6-r-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetische, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
WO2007085556A2 (en) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Use of 4-imidazole derivatives for cns disorders
CA2666762C (en) 2006-10-19 2014-12-30 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
CA2668454A1 (en) 2006-11-02 2008-05-08 F. Hoffmann-La Roche Ag Substituted 2-imidazoles
KR101134226B1 (ko) 2006-11-16 2012-04-10 에프. 호프만-라 로슈 아게 치환된 4-이미다졸
JP2010513238A (ja) 2006-12-13 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体（ｔａａｒ）に対するリガンドとしての新規２−イミダゾール
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
EP2114906B1 (de) 2007-02-02 2014-08-06 F. Hoffmann-La Roche AG 2-aminooxazolinverbindungen als taar1-liganden für erkrankungen des zentralen nervensystems
ES2525229T3 (es) 2007-02-15 2014-12-19 F. Hoffmann-La Roche Ag 2-aminooxazolinas como ligandos de TAAR1
EP2173720A2 (de) 2007-07-02 2010-04-14 F. Hoffmann-Roche AG 2-imidazoline mit guter affinität zu trace-amine-associated-rezeptoren (taars)
EP2173719A1 (de) 2007-07-03 2010-04-14 F. Hoffmann-Roche AG 4-imidazoline und ihre verwendung als antidepressiva
CA2694362A1 (en) 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
JP5341084B2 (ja) 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
DK3566703T3 (da) * 2009-02-13 2021-07-05 Allergan Inc Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
CA2856507C (en) 2011-11-21 2017-03-21 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
JP6310070B2 (ja) 2013-10-07 2018-04-11 テイコク ファーマ ユーエスエー インコーポレーテッド デクスメデトミジン経皮組成物を用いる、注意欠陥多動性障害、不安症及び不眠症の治療法及び組成物
US10987342B2 (en) 2013-10-07 2021-04-27 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
KR102537050B1 (ko) 2016-03-17 2023-05-26 에프. 호프만-라 로슈 아게 Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체
RU2723761C1 (ru) 2016-10-31 2020-06-17 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы устранения боли с использованием устройств для трансдермальной доставки дексмедетомидина
US12472158B2 (en) 2019-02-27 2025-11-18 Vanderbilt University Methods of treating trigeminal nerve pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202660A (en) 1961-10-09 1965-08-24 Boehringer Sohn Ingelheim Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
FI844786A0 (fi) * 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative

Also Published As

Publication number Publication date
AU3027289A (en) 1989-08-31
EP0331374A2 (de) 1989-09-06
ZA891493B (en) 1989-11-29
EP0331374A3 (en) 1990-10-10
KR0136790B1 (ko) 1998-04-25
HUT51139A (en) 1990-04-28
DE68913054D1 (de) 1994-03-24
GB8804683D0 (en) 1988-03-30
KR890012647A (ko) 1989-09-18
DK46489D0 (da) 1989-02-02
CA1338556C (en) 1996-08-27
HU202751B (en) 1991-04-29
DK175282B1 (da) 2004-08-09
EP0331374B1 (de) 1994-02-16
AU611262B2 (en) 1991-06-06
NZ228125A (en) 1996-12-20
JP2856410B2 (ja) 1999-02-10
JPH01294623A (ja) 1989-11-28
DE68913054T2 (de) 1994-07-07
DK46489A (da) 1989-08-30
GB2215206B (en) 1991-07-03
GB2215206A (en) 1989-09-20
IE890639L (en) 1989-08-29
IE60538B1 (en) 1994-07-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee