KR890003777A - 3-(치환된)프로페닐-7-(아미노티아졸릴아세트아미도)세프-3-엠-4-카복실산과 그것의 에스텔 - Google Patents

3-(치환된)프로페닐-7-(아미노티아졸릴아세트아미도)세프-3-엠-4-카복실산과 그것의 에스텔 Download PDF

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KR890003777A
KR890003777A KR1019880010396A KR880010396A KR890003777A KR 890003777 A KR890003777 A KR 890003777A KR 1019880010396 A KR1019880010396 A KR 1019880010396A KR 880010396 A KR880010396 A KR 880010396A KR 890003777 A KR890003777 A KR 890003777A
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South Korea
Prior art keywords
ethyl
compound
acetamido
methyl
cepam
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KR1019880010396A
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KR950008975B1 (ko
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이리무라 세이지
아베 요시오
오구무라 준
나이토 다가유기
가마찌 하지메
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이삭 쟈코브스키
브리스톨마이어즈 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

3-(치환된)프로페닐-7-(아미노티아졸릴아세트아미도)세프-3-엠-4-카복실산과 그것의 에스텔
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. R1이 수소 또는 통상적인 아미노-보호그룹, R2가 수소 2 내지 4 탄소원자를 갖는 아실, R3는 수소 또는 2 내지 3 탄소원자를 갖는 저급 알카노일옥시이며, R2와 R3는 각각 수소일때 R4도 수소이며, R4는 (5-메틸-2-옥소-1,3-디옥소렌-4-일)메틸, 1-(에톡시카보닐옥시)에틸, 1-(피발로일옥시)에틸, 1-(시클로헥실아세톡시)에틸 또는 1-(시클로 헥실옥시카르보닐옥시)에틸인 다음 일반식 화합물.
  2. R4가 (5-메틸-2-옥소-1,3-디옥소렌-4-일)메틸인 제 1 항의 화합물.
  3. (5-메틸-2-옥소-1,3-디옥소렌-4-일)메틸 7β-[(Z)-2(2-아미노티아졸-4-일)-2-(히드록시이미노)-아세트아미도]3-[(Z)-프로프-1-엔-1-일]-3-쎄팸-4-카르복실레이트인 제 2 항의 화합물.
  4. R4가 1-(에톡시카르보닐옥시)에틸인 제 1 항의 화합물.
  5. 1-(에톡시카르보닐옥시)에틸 7β-[(Z)-2(2-아미노티아졸-4-일)-2-(히드록시이미노)아세트아미도]3-[(Z)-프로프-1-엔-1-일]-3-쎄팸-4-카르복실레이트인 제 4 항의 화합물.
  6. R4가 1-(피발로일옥시)에틸인 제 1 항의 화합물.
  7. 1-(에톡시카르보닐옥시)에틸 7β-[(Z)-2(2-아미노티아졸-4-일)-2-(히드록시이미노)아세트아미도]-3-[(Z)-프로프-1-엔-1-일]-3-쎄팸-4-카르복실레이트인 제 6 항의 화합물.
  8. R4가 1-(시클로헥실아세톡시)에틸인 제 1 항의 화합물.
  9. 1-(시클로헥실아세톡시)에틸 7β-[(Z)-2(2-아미노티아졸-4-일)-2-(히드록시이미노)아세트아미도]3-[(Z)-프로프-1-엔-1-일]-3-쎄팸-4-카르복실레이트.
  10. R4가 1-(시클로헥실아세톡시)에틸인 제 1 항의 화합물.
  11. 1-(시클로헥실아세톡시)에틸 7β-[(Z)-2(2-아미노티아졸-4-일)-2-(히드록시이미노)아세트아미도]3-[(Z)-프로프-1-엔-1-일]-3-쎄팸-4-카르복실레이트인 제10항의 화합물.
  12. 산인 R4가 수소, 또는 이들의 염(나트룸, 칼륨, 트리에틸아모늄등)인 일반식 Ⅰ(R1, R2,R3는 제 1 항에 정의한 바와같음)을,
    불활성 유기용매하에 -10℃ 내지 +50℃ 온도 범위헤서 일반식 R4-X의 할로겐화된 화합물과 반응시켜서 3-(치환된)프로페닐-7-(아미노티아졸릴아세트아미도)세프-3-엠-4-카복실산 에스텔을 제조하는 방법.
    상기식에서 X는 클로로, 브로모 또는 요도이며, R4는
    으로부터 선택되는 그룹임.
  13. 제12항에 있어서, 불화활성 유기용매가 N,N-디메틸포름아미드, N,N-디메틸아세트아미드, 디메틸설폭시드, 아세톤, 아세토니트릴드인 3-(치환된)프로페닐-7-(아미노티아졸리일아세트아미도)세프-3-엠-4-카복실산에스텔을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880010396A 1987-08-17 1988-08-16 3-(치환된)프로페닐-7-(아미노티아졸릴아세트아미도)세프-3-엠-4-카복실산과 그것의 에스텔 KR950008975B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86138 1987-08-17
US086,138 1987-08-17
US07/086,138 US4874856A (en) 1985-06-24 1987-08-17 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof

Publications (2)

Publication Number Publication Date
KR890003777A true KR890003777A (ko) 1989-04-18
KR950008975B1 KR950008975B1 (ko) 1995-08-10

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Country Status (8)

Country Link
US (1) US4874856A (ko)
EP (1) EP0304036A3 (ko)
JP (1) JPH01139586A (ko)
KR (1) KR950008975B1 (ko)
AU (1) AU616899B2 (ko)
DK (1) DK458488A (ko)
FI (1) FI883771A (ko)
PT (1) PT88276B (ko)

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US5143911A (en) * 1990-08-23 1992-09-01 Bristol-Myers Squibb Company Antibiotic c-3 di-hydroxyphenyl substituted cephalosporin compounds, compositions and method of use thereof
KR950700311A (ko) * 1992-02-05 1995-01-16 게오르게스 그렐리니, 한스 루돌프하우스 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives)
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds
CA2935651A1 (en) 2007-10-09 2009-04-16 Gladius Pharmaceuticals Corporation Broad spectrum beta-lactamase inhibitors
WO2014165126A2 (en) 2013-03-12 2014-10-09 Sopharmia, Inc. Derivatized 3-styryl-cephalosporins

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Also Published As

Publication number Publication date
FI883771A0 (fi) 1988-08-15
AU2094488A (en) 1989-02-23
US4874856A (en) 1989-10-17
KR950008975B1 (ko) 1995-08-10
FI883771A (fi) 1989-02-18
AU616899B2 (en) 1991-11-14
DK458488A (da) 1989-02-18
PT88276B (pt) 1995-03-01
JPH01139586A (ja) 1989-06-01
DK458488D0 (da) 1988-08-16
PT88276A (pt) 1989-06-30
EP0304036A3 (en) 1990-11-28
EP0304036A2 (en) 1989-02-22

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