KR890002115A - 위산 분비 억제 작용을 갖는 티오메틸 및 술피닐메틸 유도체, 그의 제조 방법 및 이를 함유하는 제약 조성물 - Google Patents
위산 분비 억제 작용을 갖는 티오메틸 및 술피닐메틸 유도체, 그의 제조 방법 및 이를 함유하는 제약 조성물 Download PDFInfo
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- KR890002115A KR890002115A KR1019880009620A KR880009620A KR890002115A KR 890002115 A KR890002115 A KR 890002115A KR 1019880009620 A KR1019880009620 A KR 1019880009620A KR 880009620 A KR880009620 A KR 880009620A KR 890002115 A KR890002115 A KR 890002115A
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- het
- imidazol
- methoxy
- dimethyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (15)
- Het 의미에 따라 하기 분자 부류를 포함하는, 하기 일반식(I)로 표시되는 화합물.의 이미다졸 유도체[상기 식중 R1은 H, C1-C4알킬, 벤질 또는 페닐기(이 기는 임의의 위치에서 C1-C4알킬, C1-C4알콕시, 트리플루오로메틸 또는 할로겐에 의해 임의로 치환될 수 있음)이고, R2및 R3은 H 또는 페닐기이되, 단 R1=H인 경우에는 R2및 R3은 반드시 페닐기이고, A는 하기 구조식 중 어느 하나여기에서 R'4, R"4및 R"'4는 서로 동일하거나 또는 상이한 것으로서, 각각 수소, C1-C4알킬 또는 C1-C4알콕시기이되 단 A=(II)인 경우에는 이들은 결코 동시에 H일수는 없고, R5는 H 또는 C1-C4알콕시기이고, R6은 H 또는 벤조일기이고, R7및 R8은 서로 동일하거나 또는 상이한 것으로서, 각각 H, 히드록시-알킬, C1-C4알킬기(이 기는 이들이 결합된 질소원자와 함께 O 또는 N과 같은 헤테로원자에 의해 단속되어 피롤리딘, 피페리딘, 피페라진 또는 모르폴린 고리를 형성할 수 있음)이고, n은 0 또는 1임]B. 일반식의 푸린 유도체.[상기 식중, A는 구조식(II), (IV) 또는 (V)중 하나이고, n은 0 또는 1임]C. 일반식의 티에노-이미다졸 유도체.[상기 식중, A는 구조식(IV) 또는 (V)중 하나이고, n은 0 또는 1임]D. 일반식의 이미다조-피리딘 유도체.[상기 식중, Z 및 Z1은 서로 상이한 것으로서, N 또는 CH이고, A는 기(III),(IV) 또는 (V)중 어느 하나이되, 단 A=(IV)인 경우에는 R7및 R8은 반드시 H 또는 C1-C4알킬기와 상이하고, n은 0 또는 1임]
- 제1항에 있어서, Het가 1-메틸-이미다졸-2-일이고, n이 0 또는 1이고, A가 2-(3,5-디메틸-4'-메톡시)피리딜, 2-퀴놀리닐, 2-(4-메톡시)피리딜 또는 2-(N,N-디메틸)아닐릴인 화합물,
- 제1항에 있어서, Het가 1-페닐-이미다졸-2-일이고, n이 0 또는 1이고, A가 2-벤즈이미다졸릴, 2-(3-메틸-4'-메톡시)피리딜, 2-(N,N-디메틸)아닐릴, 또는 2-퀴놀릴인 화합물.
- 제1항에 있어서, Het가 1-(3-플루오페닐)이미다졸-2-일이고, n이 0 또는 1이고, A가 2-벤즈이미다졸릴, 2-(3-메틸-4'-메톡시)피리딜 또는 2-(N,N-디메틸)아닐릴인 화합물.
- 제1항에 있어서, Het가 1-(4-플루오로페닐)이미다졸-2-일이고, n이 0 또는 1이고, A가 2-벤즈이미다졸릴, 2-(3-메틸-4-메톡시)피리딜 또는 2-(N,N-디메틸)아닐릴인 화합물.
- 제1항에 있어서, Het가 1-(2-클로로페닐)-이미다졸-2-일이고, 1-(4-클로로페닐)이미다졸-2-일, 1-(2-플루오로페닐)이미다졸-2-일, 1-(4-메톡시페닐)이미아졸-2-일, 1-(2-트리플루오로메틸페닐)이미다졸-2일이고, n이 0 또는 1이고, A가 2-(N,N-디메틸)아닐릴인 화합물.
- 제1항에 있어서, Het가 4,5-디페닐-이미다졸-2-일이고, n이 0 또는 1이고, A가 2-(3,5-디메틸-4-메톡시)피리딜 또는 2-(N,N-디메틸)아닐릴인 화합물.
- 제1항에 있어서, Het가 6-푸리닐이고, A가 2-(3-메톡시-6-메틸)피리딜 또 2-(4-메톡시-3-메틸)피리딜이고, n이 0 또는 1인 화합물.
- 제1항에 있어서, Het가 1H-이미다졸-[4,5-b]피ㅣ딘-2-일이고, n이 0 또는 1이고, A가 2-벤즈이미다졸릴, 2-퀴놀린 또는 1-(4-모르폴리닐)페닐인 화합물.
- 8-[2'-(N,N-디메틸아닐릴)메틸티오]푸린, 2-(2'-(N,N-디메틸아닐릴)메틸티오]이미다조-[4,5-c]피리딘, 2-[2'-(N,N-디메틸아닐릴)메틸티오]티에노-[3,4-d]이미다졸로 되는 군중에서 선택되는 화합물.
- A가 일반식(III)의 기이고, R6이 벤조일인 일반식(I)의 화합물 제조용 중간체로서의 5-벤조일-2-클로로메틸-벤즈이미다졸.
- 일반식 Het-SH(여기에서 Het는 제1항에 정의한 바와 같음)의 화합물을 메탄올, 에탄올 또는 알코올/물 혼합물과 같은 극성 용매와, 트리에틸아민과 같은 삼급 아민으로 되는 유기염기 또는 수산화나트륨 또는 수산화칼륨과 같은 무기 염기 존재하에 일반식 X-CH2-A(여기에서 A는 제1항에서 정의한 바와 같고, X가 할로겐임)의 화합물과 반응시키는 것으로 되는 n=0인 제1항 내지 제10항에 의한 화합물의 제조방법.
- 제12항에 있어서, 반응을 유기상이 테트라히드로푸란 또는 디옥산과 같은 에테르, 염화 메틸렌 또는 클로로포름과 같은 할로겐화 탄화수소, 포름아미드 또는 디메틸포름아미드와 같은 아미드로 되고, 무기상이 메탄올 또는 에탄올과 같은 알코올 또는 알코올/물 혼합물로 되는 이사 시스템으로 행하는 방법.
- 제12항 내지 제13항에 의한 방법으로 제조한 n=0인 대응하는 화합물을 에탄올, 디메틸포름아미드, 에틸 에테르, 염화메틸렌, 클로로포름, 디클로로에탄, 벤젠 등과 같은 유기 용매 중에서 m-클로로과벤조산, p-니트로과벤조산, 과산화수소, 메타과요오드산 나트륨, 이산화 셀레늄, 이산화 망간과 같은 산화제를 사용하여 산화시키는 것으로 되는 제1항 내지 제9항에 의한 화합물의 제조방법.
- 조성물의 0.1 내지 95중량%로 되는 양의 일반식(I)의 화합물과, 임의의 제약상 허용되는 부형제를 함유하는 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21538/87A IT1222412B (it) | 1987-07-31 | 1987-07-31 | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
IT21538A/87 | 1988-07-31 |
Publications (1)
Publication Number | Publication Date |
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KR890002115A true KR890002115A (ko) | 1989-04-07 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019880009620A KR890002115A (ko) | 1987-07-31 | 1988-07-29 | 위산 분비 억제 작용을 갖는 티오메틸 및 술피닐메틸 유도체, 그의 제조 방법 및 이를 함유하는 제약 조성물 |
Country Status (13)
Country | Link |
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US (2) | US5049566A (ko) |
EP (1) | EP0301422A3 (ko) |
JP (1) | JPS6463575A (ko) |
KR (1) | KR890002115A (ko) |
AU (1) | AU615933B2 (ko) |
DK (1) | DK427288A (ko) |
FI (1) | FI883511A (ko) |
HU (1) | HU201058B (ko) |
IT (1) | IT1222412B (ko) |
NO (1) | NO172489C (ko) |
NZ (1) | NZ225629A (ko) |
PT (1) | PT88141A (ko) |
ZA (1) | ZA885585B (ko) |
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JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
DE3639926A1 (de) * | 1986-11-22 | 1988-06-01 | Hoechst Ag | Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
AU622866B2 (en) * | 1987-07-21 | 1992-04-30 | Hoechst Aktiengesellschaft | Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
JPS6440467A (en) * | 1987-08-04 | 1989-02-10 | Hisamitsu Pharmaceutical Co | Novel substituted diphenylimidazole derivative |
JP2582406B2 (ja) * | 1988-04-11 | 1997-02-19 | 日清製粉株式会社 | 新規なキノキサリン誘導体及びそれを含有する坑潰瘍剤 |
JP2614756B2 (ja) * | 1988-08-10 | 1997-05-28 | 日本ケミファ株式会社 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
JP2679745B2 (ja) * | 1989-06-29 | 1997-11-19 | 明治製菓株式会社 | アゾール誘導体及びそれらを有効成分とする抗潰瘍剤 |
ZA906247B (en) * | 1989-08-10 | 1991-06-26 | Nippon Chemiphar Co | Novel imidazole derivatives,process for the preparation of the same and antiulcer agents containing the same |
JP2933739B2 (ja) * | 1990-04-09 | 1999-08-16 | 明治製菓株式会社 | チアゾールまたはイミダゾール誘導体および抗潰瘍剤 |
JPH0770083A (ja) * | 1993-07-05 | 1995-03-14 | Nippon Chemiphar Co Ltd | イミダゾール誘導体を有効成分とする血圧降下剤 |
JP3046924B2 (ja) * | 1995-03-27 | 2000-05-29 | 株式会社アラクス | イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬 |
FR2751649B1 (fr) * | 1996-07-26 | 1998-08-28 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6159968A (en) * | 1998-01-15 | 2000-12-12 | University Of Cincinnati | Activation of chloride channels for correction of defective chloride transport |
EP2576540B1 (en) * | 2010-05-26 | 2019-09-04 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
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GB2038825B (en) * | 1978-12-16 | 1983-02-09 | Wyeth John & Brother Ltd | Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups |
US4330552A (en) * | 1980-11-06 | 1982-05-18 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-arylthioimidazoles |
AU4640985A (en) * | 1984-08-31 | 1986-03-06 | Nippon Chemiphar Co. Ltd. | Benzimidazole derivatives |
DE3579436D1 (de) * | 1984-12-18 | 1990-10-04 | Otsuka Pharma Co Ltd | Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen. |
FI861772A (fi) * | 1985-05-07 | 1986-11-08 | Chemie Linz Ag | Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning. |
AR243167A1 (es) * | 1985-08-24 | 1993-07-30 | Hoechst Ag | Procedimiento para la preparacion de toluidinas sustituidas. |
KR950001015B1 (ko) * | 1986-01-10 | 1995-02-07 | 닛뽕 케미화 가부시끼가이샤 | 술폭시드 유도체의 제조방법 |
EP0234485B1 (de) * | 1986-02-20 | 1992-04-01 | Hoechst Aktiengesellschaft | Substituierte Thienoimidazol-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Magensäuresekretionshemmer |
WO1987005296A1 (en) * | 1986-03-07 | 1987-09-11 | Pfizer Inc. | 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents |
JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
DE3639926A1 (de) * | 1986-11-22 | 1988-06-01 | Hoechst Ag | Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
DE3723327A1 (de) * | 1987-07-15 | 1989-02-02 | Hoechst Ag | Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
-
1987
- 1987-07-31 IT IT21538/87A patent/IT1222412B/it active
-
1988
- 1988-07-22 EP EP88111813A patent/EP0301422A3/en not_active Ceased
- 1988-07-26 FI FI883511A patent/FI883511A/fi not_active Application Discontinuation
- 1988-07-28 JP JP63189533A patent/JPS6463575A/ja active Pending
- 1988-07-29 DK DK427288A patent/DK427288A/da not_active Application Discontinuation
- 1988-07-29 ZA ZA885585A patent/ZA885585B/xx unknown
- 1988-07-29 KR KR1019880009620A patent/KR890002115A/ko not_active Application Discontinuation
- 1988-07-29 HU HU884043A patent/HU201058B/hu not_active IP Right Cessation
- 1988-07-29 NO NO883392A patent/NO172489C/no unknown
- 1988-07-29 NZ NZ225629A patent/NZ225629A/xx unknown
- 1988-07-29 PT PT88141A patent/PT88141A/pt unknown
- 1988-08-01 AU AU20228/88A patent/AU615933B2/en not_active Ceased
-
1990
- 1990-03-14 US US07/493,957 patent/US5049566A/en not_active Expired - Fee Related
- 1990-03-14 US US07/494,864 patent/US5066652A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI883511A (fi) | 1989-02-01 |
NO172489B (no) | 1993-04-19 |
EP0301422A2 (en) | 1989-02-01 |
NO883392L (no) | 1989-02-01 |
NZ225629A (en) | 1991-01-29 |
FI883511A0 (fi) | 1988-07-26 |
NO172489C (no) | 1993-07-28 |
AU2022888A (en) | 1989-02-02 |
AU615933B2 (en) | 1991-10-17 |
JPS6463575A (en) | 1989-03-09 |
ZA885585B (en) | 1989-04-26 |
IT8721538A0 (it) | 1987-07-31 |
HUT47930A (en) | 1989-04-28 |
US5049566A (en) | 1991-09-17 |
DK427288A (da) | 1989-02-01 |
HU201058B (en) | 1990-09-28 |
EP0301422A3 (en) | 1990-03-28 |
PT88141A (pt) | 1989-06-30 |
US5066652A (en) | 1991-11-19 |
IT1222412B (it) | 1990-09-05 |
NO883392D0 (no) | 1988-07-29 |
DK427288D0 (da) | 1988-07-29 |
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