ATE303376T1 - Tricyclische kondensierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung - Google Patents
Tricyclische kondensierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendungInfo
- Publication number
- ATE303376T1 ATE303376T1 AT00935528T AT00935528T ATE303376T1 AT E303376 T1 ATE303376 T1 AT E303376T1 AT 00935528 T AT00935528 T AT 00935528T AT 00935528 T AT00935528 T AT 00935528T AT E303376 T1 ATE303376 T1 AT E303376T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- inhibition
- independently
- alkyl group
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15718199 | 1999-06-03 | ||
PCT/JP2000/003592 WO2000075127A1 (fr) | 1999-06-03 | 2000-06-02 | Composes heterocycliques condenses a trois cycles, procede de preparation correspondant et utilisation de tels composes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE303376T1 true ATE303376T1 (de) | 2005-09-15 |
Family
ID=15643970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00935528T ATE303376T1 (de) | 1999-06-03 | 2000-06-02 | Tricyclische kondensierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
Country Status (22)
Country | Link |
---|---|
US (3) | US6602898B1 (de) |
EP (1) | EP1182200B1 (de) |
JP (1) | JP3471778B2 (de) |
KR (1) | KR20020016812A (de) |
CN (1) | CN1192027C (de) |
AT (1) | ATE303376T1 (de) |
AU (1) | AU777414B2 (de) |
BG (1) | BG106169A (de) |
BR (1) | BR0011529A (de) |
CA (1) | CA2370013A1 (de) |
CZ (1) | CZ20014261A3 (de) |
DE (1) | DE60022341T2 (de) |
DK (1) | DK1182200T3 (de) |
ES (1) | ES2248080T3 (de) |
HU (1) | HUP0201203A3 (de) |
IL (1) | IL146732A0 (de) |
NO (1) | NO20015832L (de) |
NZ (1) | NZ515666A (de) |
PL (1) | PL352840A1 (de) |
RU (1) | RU2211837C2 (de) |
WO (1) | WO2000075127A1 (de) |
ZA (1) | ZA200109565B (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
JP5773585B2 (ja) * | 2009-06-29 | 2015-09-02 | 日東電工株式会社 | 発光性トリアリール |
TWI698430B (zh) * | 2015-02-13 | 2020-07-11 | 南北兄弟藥業投資有限公司 | 三環化合物及其在藥物中的應用 |
TW201808283A (zh) | 2016-08-05 | 2018-03-16 | 廣東東陽光藥業有限公司 | 含氮三環化合物及其在藥物中的應用 |
US10654797B2 (en) | 2016-11-03 | 2020-05-19 | North & South Brother Pharmacy Investment Company Limited | Solid forms of an adamantyl compound, compositions and uses thereof |
CN110128432B (zh) * | 2018-02-02 | 2021-03-02 | 广东东阳光药业有限公司 | 含氮三环化合物及其在药物中的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302590B (de) | 1966-08-03 | 1970-11-12 | ||
US4104280A (en) | 1977-02-04 | 1978-08-01 | Syntex (U.S.A.) Inc. | Dibenzo [b.f]thiepin and dibenzo[b.f]oxepin derivatives |
PT68303A (en) | 1977-07-26 | 1978-08-01 | Merck & Co Inc | Process for the preparation of dibenzo/b,f/thiepin |
JPS54122284A (en) | 1978-02-17 | 1979-09-21 | Dainippon Pharmaceut Co Ltd | Dibenzb,foxepin derivative |
JPS54115388A (en) | 1978-03-01 | 1979-09-07 | Nippon Chemiphar Co Ltd | Acetic acid derivative and its preparation |
US4237160A (en) | 1979-11-27 | 1980-12-02 | Merck Sharp & Dohme (I.A.) Corp. | 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists |
DE3203065A1 (de) | 1982-01-30 | 1983-08-04 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von dibenzoxepinonen |
FR2693655B1 (fr) | 1992-07-20 | 1994-10-14 | Virbac | Vaccin antirabique avirulent. |
DK0805155T3 (da) | 1994-09-28 | 2002-07-08 | Nippon Suisan Kaisha Ltd | Hidtil ukendt tricyklisk, kondenseret heterocyklisk antioxidantforbindelse |
ATE203528T1 (de) * | 1995-02-08 | 2001-08-15 | Novartis Erfind Verwalt Gmbh | Antineurodegenerativ wirksame 10-aminoaliphatyl- dibenz- b,f oxepine |
WO1996025927A1 (fr) | 1995-02-22 | 1996-08-29 | Nippon Suisan Kaisha, Ltd. | Inhibiteur des recepteurs de l'acide glutamique et ameliorant des fonctions cerebrales |
EP0885610A4 (de) | 1996-01-19 | 1999-04-21 | Nippon Suisan Kaisha Ltd | Relaxans für die glatte luftröhrenmuskulatur |
JPH10204079A (ja) * | 1997-01-20 | 1998-08-04 | Nippon Suisan Kaisha Ltd | ジベンゾオキセピンおよびジベンゾチエピン誘導体の製造方法 |
KR100447674B1 (ko) * | 1997-04-15 | 2004-09-08 | 교와 핫꼬 고교 가부시끼가이샤 | 삼환식 화합물 |
-
2000
- 2000-06-02 AT AT00935528T patent/ATE303376T1/de not_active IP Right Cessation
- 2000-06-02 IL IL14673200A patent/IL146732A0/xx unknown
- 2000-06-02 PL PL00352840A patent/PL352840A1/xx not_active Application Discontinuation
- 2000-06-02 BR BR0011529-0A patent/BR0011529A/pt not_active IP Right Cessation
- 2000-06-02 JP JP2001502410A patent/JP3471778B2/ja not_active Expired - Fee Related
- 2000-06-02 KR KR1020017015458A patent/KR20020016812A/ko not_active Application Discontinuation
- 2000-06-02 NZ NZ515666A patent/NZ515666A/en unknown
- 2000-06-02 CZ CZ20014261A patent/CZ20014261A3/cs unknown
- 2000-06-02 CN CNB008084319A patent/CN1192027C/zh not_active Expired - Fee Related
- 2000-06-02 DE DE60022341T patent/DE60022341T2/de not_active Expired - Fee Related
- 2000-06-02 WO PCT/JP2000/003592 patent/WO2000075127A1/ja not_active Application Discontinuation
- 2000-06-02 EP EP00935528A patent/EP1182200B1/de not_active Expired - Lifetime
- 2000-06-02 CA CA002370013A patent/CA2370013A1/en not_active Abandoned
- 2000-06-02 DK DK00935528T patent/DK1182200T3/da active
- 2000-06-02 ES ES00935528T patent/ES2248080T3/es not_active Expired - Lifetime
- 2000-06-02 HU HU0201203A patent/HUP0201203A3/hu unknown
- 2000-06-02 RU RU2001132596/04A patent/RU2211837C2/ru not_active IP Right Cessation
- 2000-06-02 US US09/980,581 patent/US6602898B1/en not_active Expired - Fee Related
- 2000-06-02 AU AU51044/00A patent/AU777414B2/en not_active Ceased
-
2001
- 2001-11-20 ZA ZA200109565A patent/ZA200109565B/en unknown
- 2001-11-29 NO NO20015832A patent/NO20015832L/no not_active Application Discontinuation
- 2001-12-03 BG BG106169A patent/BG106169A/bg unknown
-
2002
- 2002-11-12 US US10/291,429 patent/US6700013B2/en not_active Expired - Fee Related
-
2003
- 2003-12-05 US US10/727,644 patent/US7410997B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20015832L (no) | 2002-02-01 |
AU5104400A (en) | 2000-12-28 |
US6602898B1 (en) | 2003-08-05 |
BG106169A (bg) | 2002-05-31 |
DK1182200T3 (da) | 2005-12-27 |
IL146732A0 (en) | 2002-07-25 |
US20030220360A1 (en) | 2003-11-27 |
HUP0201203A2 (en) | 2002-08-28 |
JP3471778B2 (ja) | 2003-12-02 |
RU2211837C2 (ru) | 2003-09-10 |
CN1192027C (zh) | 2005-03-09 |
US6700013B2 (en) | 2004-03-02 |
US20040127713A1 (en) | 2004-07-01 |
WO2000075127A8 (fr) | 2001-03-15 |
DE60022341T2 (de) | 2006-06-29 |
NO20015832D0 (no) | 2001-11-29 |
DE60022341D1 (de) | 2005-10-06 |
CN1353703A (zh) | 2002-06-12 |
BR0011529A (pt) | 2002-12-17 |
CZ20014261A3 (cs) | 2002-06-12 |
HUP0201203A3 (en) | 2004-12-28 |
NZ515666A (en) | 2003-10-31 |
CA2370013A1 (en) | 2000-12-14 |
PL352840A1 (en) | 2003-09-08 |
ES2248080T3 (es) | 2006-03-16 |
EP1182200B1 (de) | 2005-08-31 |
KR20020016812A (ko) | 2002-03-06 |
AU777414B2 (en) | 2004-10-14 |
EP1182200A1 (de) | 2002-02-27 |
US7410997B2 (en) | 2008-08-12 |
EP1182200A9 (de) | 2002-05-22 |
WO2000075127A1 (fr) | 2000-12-14 |
ZA200109565B (en) | 2003-04-11 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 1182200 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |