IT8721538A0 - Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. - Google Patents

Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.

Info

Publication number
IT8721538A0
IT8721538A0 IT8721538A IT2153887A IT8721538A0 IT 8721538 A0 IT8721538 A0 IT 8721538A0 IT 8721538 A IT8721538 A IT 8721538A IT 2153887 A IT2153887 A IT 2153887A IT 8721538 A0 IT8721538 A0 IT 8721538A0
Authority
IT
Italy
Prior art keywords
sulfinil
secretive
thiomethyl
contain
action
Prior art date
Application number
IT8721538A
Other languages
English (en)
Other versions
IT1222412B (it
Inventor
Paolo Chiesi
Vittorino Servadio
Roberta Razzetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of IT8721538A0 publication Critical patent/IT8721538A0/it
Priority to IT21538/87A priority Critical patent/IT1222412B/it
Priority to EP88111813A priority patent/EP0301422A3/en
Priority to FI883511A priority patent/FI883511A/fi
Priority to JP63189533A priority patent/JPS6463575A/ja
Priority to ZA885585A priority patent/ZA885585B/xx
Priority to HU884043A priority patent/HU201058B/hu
Priority to NZ225629A priority patent/NZ225629A/xx
Priority to DK427288A priority patent/DK427288A/da
Priority to NO883392A priority patent/NO172489C/no
Priority to PT88141A priority patent/PT88141A/pt
Priority to KR1019880009620A priority patent/KR890002115A/ko
Priority to AU20228/88A priority patent/AU615933B2/en
Priority to US07/493,957 priority patent/US5049566A/en
Priority to US07/494,864 priority patent/US5066652A/en
Application granted granted Critical
Publication of IT1222412B publication Critical patent/IT1222412B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT21538/87A 1987-07-31 1987-07-31 Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono IT1222412B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT21538/87A IT1222412B (it) 1987-07-31 1987-07-31 Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
EP88111813A EP0301422A3 (en) 1987-07-31 1988-07-22 Thiomethyl and sulfinylmethyl derivatives having gastric acid antisecretory activity, processes for the preparation thereof and pharmaceutical compositions containing them
FI883511A FI883511A (fi) 1987-07-31 1988-07-26 Derivat av tiometyl och svavelmetyl som har en effekt som motverkar sekretion av magsyra, processer foer deras framstaellning samt farmaceutiska sammansaettningar som ingaor i dem.
JP63189533A JPS6463575A (en) 1987-07-31 1988-07-28 Thiomethyl and sulfinylmethyl derivative having gastric acid secretion control, manufacture and pharmaceutical composition
NZ225629A NZ225629A (en) 1987-07-31 1988-07-29 Thioether and sulphoxide derivatives containing imidazolyl, purinyl, thioimidazolyl and imidazopyridyl radicals; pharmaceutical compositions
HU884043A HU201058B (en) 1987-07-31 1988-07-29 Process for producing pharmaceutical compositions containing heterocyclic thiomethyl- and sulfinyl-methyl-derivatives and the active components
ZA885585A ZA885585B (en) 1987-07-31 1988-07-29 Thiomethyl and sufinylmethyl derivatives having gastric acid antisecretory activity processes for the preparation thereof and pharmaceutical compositions containing them
DK427288A DK427288A (da) 1987-07-31 1988-07-29 Thiomethyl- og sulfinylmethylderivater med mavesyresekretorisk aktivitet, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
NO883392A NO172489C (no) 1987-07-31 1988-07-29 Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazolderivater
PT88141A PT88141A (pt) 1987-07-31 1988-07-29 Process for preparing thiomethyl and sulfinylmethyl derivativeshaving gastric acid antisecretory activity
KR1019880009620A KR890002115A (ko) 1987-07-31 1988-07-29 위산 분비 억제 작용을 갖는 티오메틸 및 술피닐메틸 유도체, 그의 제조 방법 및 이를 함유하는 제약 조성물
AU20228/88A AU615933B2 (en) 1987-07-31 1988-08-01 Thiomethyl and sulfinylmethyl derivatives having gastric acid antisecretory activity, processes for the preparation thereof and pharmaceutical compositions containing them
US07/493,957 US5049566A (en) 1987-07-31 1990-03-14 Imidazole [4,5-c] pyridine derivatives having gastric acid antisecretory activity and pharmaceutical compositions containing them
US07/494,864 US5066652A (en) 1987-07-31 1990-03-14 Thiomethyl and sulfinylmethyl derivatives having gastric acid antisectetory activity and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21538/87A IT1222412B (it) 1987-07-31 1987-07-31 Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono

Publications (2)

Publication Number Publication Date
IT8721538A0 true IT8721538A0 (it) 1987-07-31
IT1222412B IT1222412B (it) 1990-09-05

Family

ID=11183290

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21538/87A IT1222412B (it) 1987-07-31 1987-07-31 Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono

Country Status (13)

Country Link
US (2) US5049566A (it)
EP (1) EP0301422A3 (it)
JP (1) JPS6463575A (it)
KR (1) KR890002115A (it)
AU (1) AU615933B2 (it)
DK (1) DK427288A (it)
FI (1) FI883511A (it)
HU (1) HU201058B (it)
IT (1) IT1222412B (it)
NO (1) NO172489C (it)
NZ (1) NZ225629A (it)
PT (1) PT88141A (it)
ZA (1) ZA885585B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
AU622866B2 (en) * 1987-07-21 1992-04-30 Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JPS6440467A (en) * 1987-08-04 1989-02-10 Hisamitsu Pharmaceutical Co Novel substituted diphenylimidazole derivative
JP2582406B2 (ja) * 1988-04-11 1997-02-19 日清製粉株式会社 新規なキノキサリン誘導体及びそれを含有する坑潰瘍剤
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JP2679745B2 (ja) * 1989-06-29 1997-11-19 明治製菓株式会社 アゾール誘導体及びそれらを有効成分とする抗潰瘍剤
EP0412529B1 (en) * 1989-08-10 1994-03-09 Nippon Chemiphar Co., Ltd. Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same
JP2933739B2 (ja) * 1990-04-09 1999-08-16 明治製菓株式会社 チアゾールまたはイミダゾール誘導体および抗潰瘍剤
JPH0770083A (ja) * 1993-07-05 1995-03-14 Nippon Chemiphar Co Ltd イミダゾール誘導体を有効成分とする血圧降下剤
JP3046924B2 (ja) * 1995-03-27 2000-05-29 株式会社アラクス イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6159968A (en) * 1998-01-15 2000-12-12 University Of Cincinnati Activation of chloride channels for correction of defective chloride transport
WO2011150156A2 (en) * 2010-05-26 2011-12-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2580475A (en) * 1947-10-30 1952-01-01 Schering Corp Imidazolinylalkyl ethers of pyridylcarbinols
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
GB2038825B (en) * 1978-12-16 1983-02-09 Wyeth John & Brother Ltd Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
DK585485A (da) * 1984-12-18 1986-08-08 Utsuka Pharm Co Ltd Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse
FI861772A (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
AR243167A1 (es) * 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
EP0234485B1 (de) * 1986-02-20 1992-04-01 Hoechst Aktiengesellschaft Substituierte Thienoimidazol-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Magensäuresekretionshemmer
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
NO883392D0 (no) 1988-07-29
DK427288D0 (da) 1988-07-29
KR890002115A (ko) 1989-04-07
NZ225629A (en) 1991-01-29
FI883511A (fi) 1989-02-01
FI883511A0 (fi) 1988-07-26
US5049566A (en) 1991-09-17
NO883392L (no) 1989-02-01
AU615933B2 (en) 1991-10-17
IT1222412B (it) 1990-09-05
AU2022888A (en) 1989-02-02
JPS6463575A (en) 1989-03-09
US5066652A (en) 1991-11-19
HUT47930A (en) 1989-04-28
PT88141A (pt) 1989-06-30
HU201058B (en) 1990-09-28
EP0301422A3 (en) 1990-03-28
EP0301422A2 (en) 1989-02-01
DK427288A (da) 1989-02-01
ZA885585B (en) 1989-04-26
NO172489B (no) 1993-04-19
NO172489C (no) 1993-07-28

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