KR880002300B1 - 크산틴 유도체의 제조방법 - Google Patents

크산틴 유도체의 제조방법 Download PDF

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Publication number
KR880002300B1
KR880002300B1 KR8204320A KR820004320A KR880002300B1 KR 880002300 B1 KR880002300 B1 KR 880002300B1 KR 8204320 A KR8204320 A KR 8204320A KR 820004320 A KR820004320 A KR 820004320A KR 880002300 B1 KR880002300 B1 KR 880002300B1
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KR
South Korea
Prior art keywords
formula
carbon atoms
alkyl
group
compound
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Expired
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KR8204320A
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English (en)
Korean (ko)
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KR840001576A (ko
Inventor
푸르러 하랄트
아나그노스토풀로스 히리스토
게베르트 울리히
힌쯔 하인쯔-요아힘
Original Assignee
하인리히 백커, 베른 하르트 백크
훽스트 아크티엔 게젤샤프트
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Publication of KR840001576A publication Critical patent/KR840001576A/ko
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Publication of KR880002300B1 publication Critical patent/KR880002300B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pyrane Compounds (AREA)
KR8204320A 1981-09-26 1982-09-24 크산틴 유도체의 제조방법 Expired KR880002300B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19813138397 DE3138397A1 (de) 1981-09-26 1981-09-26 "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
DE3128397.1 1981-09-26
DEP3128397.1 1981-09-26

Publications (2)

Publication Number Publication Date
KR840001576A KR840001576A (ko) 1984-05-07
KR880002300B1 true KR880002300B1 (ko) 1988-10-22

Family

ID=6142714

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204320A Expired KR880002300B1 (ko) 1981-09-26 1982-09-24 크산틴 유도체의 제조방법

Country Status (18)

Country Link
US (2) US4616020A (https=)
EP (1) EP0075850B1 (https=)
JP (1) JP2550301B2 (https=)
KR (1) KR880002300B1 (https=)
AT (1) ATE17005T1 (https=)
AU (1) AU554227B2 (https=)
CA (1) CA1286292C (https=)
DE (2) DE3138397A1 (https=)
DK (1) DK148844C (https=)
ES (3) ES8606346A1 (https=)
FI (1) FI73681C (https=)
GR (1) GR76734B (https=)
HU (1) HU186125B (https=)
IE (1) IE53911B1 (https=)
IL (1) IL66864A0 (https=)
NO (1) NO158678C (https=)
PT (1) PT75604B (https=)
ZA (1) ZA827012B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
EP0262344B1 (de) * 1986-08-07 1996-03-27 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG N-alkylierte quartäre stickstoffhaltige Heterozyklen, Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln
FR2611716A1 (fr) * 1987-03-06 1988-09-09 Uriach Cia Sa J Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US6469017B1 (en) * 1998-01-16 2002-10-22 Cell Therapeutics, Inc. Method of inhibiting interleukin-12 signaling
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
DE69531506T2 (de) * 1994-12-13 2004-06-24 Euroceltique S.A. Arylthioxanthine
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
AU9259101A (en) * 2000-09-08 2002-03-22 Cv Therapeutics Inc Purine ribosides as antiarrhythmics
JP4483683B2 (ja) 2005-04-28 2010-06-16 日立工機株式会社 連ねじドライバ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2575344A (en) * 1946-03-01 1951-11-20 State Of Iowa Dihydroxypropyl theophylline
US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
DE2335170C2 (de) * 1973-07-11 1989-07-20 Hoechst Ag, 6230 Frankfurt 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE1911279A1 (de) * 1969-03-05 1970-11-12 Eckert Dr Theodor Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen
US4031218A (en) * 1976-04-28 1977-06-21 Mallinckrodt, Inc. 7-(2,3-Dihydroxypropyl-1,3-di-n-propylxanthine and a pharmaceutical composition containing same useful as a bronchial muscle relaxant
US4397779A (en) * 1978-08-09 1983-08-09 Baxter Travenol Laboratories, Inc. Preparation of xanthine tracers
IL59664A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
IT1195267B (it) * 1980-04-15 1988-10-12 Abc Ist Biolog Chem Spa Derivati teofillinmetildiossolanici,procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
EP0075850A3 (en) 1983-07-27
HU186125B (en) 1985-06-28
KR840001576A (ko) 1984-05-07
IE822322L (en) 1983-03-26
CA1286292C (en) 1991-07-16
FI823274A0 (fi) 1982-09-23
PT75604A (de) 1982-10-01
ATE17005T1 (de) 1986-01-15
US4616020A (en) 1986-10-07
DK148844C (da) 1986-03-17
NO158678C (no) 1988-10-19
JPS5867687A (ja) 1983-04-22
GR76734B (https=) 1984-08-30
EP0075850A2 (de) 1983-04-06
FI73681B (fi) 1987-07-31
IE53911B1 (en) 1989-04-12
ES528122A0 (es) 1984-08-01
AU554227B2 (en) 1986-08-14
ES8606346A1 (es) 1986-04-01
ZA827012B (en) 1983-07-27
ES515936A0 (es) 1986-04-01
PT75604B (de) 1985-07-26
ES8406479A1 (es) 1984-08-01
AU8866382A (en) 1983-04-14
ES528123A0 (es) 1984-08-16
DE3268041D1 (en) 1986-01-30
EP0075850B1 (de) 1985-12-18
FI73681C (fi) 1987-11-09
FI823274L (fi) 1983-03-27
US4713455A (en) 1987-12-15
NO823239L (no) 1983-03-28
DK148844B (da) 1985-10-21
JP2550301B2 (ja) 1996-11-06
NO158678B (no) 1988-07-11
DK426982A (da) 1983-03-27
ES8407048A1 (es) 1984-08-16
DE3138397A1 (de) 1983-04-07
IL66864A0 (en) 1982-12-31

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