ES8407048A1 - Procedimiento de preparacion de derivados de xantina (como divisional de la solicitud de patente de invencion no.515936, solicitada el 24.9.82) - Google Patents

Procedimiento de preparacion de derivados de xantina (como divisional de la solicitud de patente de invencion no.515936, solicitada el 24.9.82)

Info

Publication number
ES8407048A1
ES8407048A1 ES528123A ES528123A ES8407048A1 ES 8407048 A1 ES8407048 A1 ES 8407048A1 ES 528123 A ES528123 A ES 528123A ES 528123 A ES528123 A ES 528123A ES 8407048 A1 ES8407048 A1 ES 8407048A1
Authority
ES
Spain
Prior art keywords
xanthines
omega
atoms
preparation
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528123A
Other languages
English (en)
Other versions
ES528123A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES528123A0 publication Critical patent/ES528123A0/es
Publication of ES8407048A1 publication Critical patent/ES8407048A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE XANTINA, DE FORMULA (I), EN LA QUE R, R Y R PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE ALCOHILACION DE UN COMPUESTO DE FORMULA (II), EN PRESENCIA DE AGENTES BASICOS, FORMULA EN LA QUE UNO DE R1, R2 O R3 ES UN GRUPO DE FORMULA (III), EN LA QUE LA CADENA ALCOHILICA TIENE 4-8 ATOMOS DE CARBONO, R ES HIDROGENO O METILO E Y PUEDE SER VARIOS RADICALES.TAMBIEN SE PUEDE HACER REACCIONAR UNA SAL DEL COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R-X, EN LA QUE X ES UN GRUPO NUCLEOFILO Y R ES UN RADICAL ALCOHILO.ESTISCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES OBSTRUCTIVAS DE LAS VIAS RESPIRATORIAS.
ES528123A 1981-09-26 1983-12-16 Procedimiento de preparacion de derivados de xantina (como divisional de la solicitud de patente de invencion no.515936, solicitada el 24.9.82) Expired ES8407048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813138397 DE3138397A1 (de) 1981-09-26 1981-09-26 "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"

Publications (2)

Publication Number Publication Date
ES528123A0 ES528123A0 (es) 1984-08-16
ES8407048A1 true ES8407048A1 (es) 1984-08-16

Family

ID=6142714

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515936A Expired ES8606346A1 (es) 1981-09-26 1982-09-24 "procedimiento de preparacion de derivados de xantina".
ES528122A Granted ES528122A0 (es) 1981-09-26 1983-12-16 Procedimiento de preparacion de derivados de yantina como divisional de la solicitud de patente de invencion numero 515.936,solicitada el 24 de septiembre de 1982)(como divisional de la patente numero 515.936)
ES528123A Expired ES8407048A1 (es) 1981-09-26 1983-12-16 Procedimiento de preparacion de derivados de xantina (como divisional de la solicitud de patente de invencion no.515936, solicitada el 24.9.82)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES515936A Expired ES8606346A1 (es) 1981-09-26 1982-09-24 "procedimiento de preparacion de derivados de xantina".
ES528122A Granted ES528122A0 (es) 1981-09-26 1983-12-16 Procedimiento de preparacion de derivados de yantina como divisional de la solicitud de patente de invencion numero 515.936,solicitada el 24 de septiembre de 1982)(como divisional de la patente numero 515.936)

Country Status (18)

Country Link
US (2) US4616020A (es)
EP (1) EP0075850B1 (es)
JP (1) JP2550301B2 (es)
KR (1) KR880002300B1 (es)
AT (1) ATE17005T1 (es)
AU (1) AU554227B2 (es)
CA (1) CA1286292C (es)
DE (2) DE3138397A1 (es)
DK (1) DK148844C (es)
ES (3) ES8606346A1 (es)
FI (1) FI73681C (es)
GR (1) GR76734B (es)
HU (1) HU186125B (es)
IE (1) IE53911B1 (es)
IL (1) IL66864A0 (es)
NO (1) NO158678C (es)
PT (1) PT75604B (es)
ZA (1) ZA827012B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
AU607709B2 (en) * 1986-08-07 1991-03-14 Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg A micelle containing a hydrophobic pharmaceutically active substance
FR2611716A1 (fr) * 1987-03-06 1988-09-09 Uriach Cia Sa J Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US6469017B1 (en) * 1998-01-16 2002-10-22 Cell Therapeutics, Inc. Method of inhibiting interleukin-12 signaling
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
ES2215146T3 (es) * 2000-09-08 2004-10-01 Cv Therapeutics, Inc. Utilizacion de ribosidos purina como antiarritmicos.
JP4483683B2 (ja) 2005-04-28 2010-06-16 日立工機株式会社 連ねじドライバ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2575344A (en) * 1946-03-01 1951-11-20 State Of Iowa Dihydroxypropyl theophylline
US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
DE2335170C2 (de) * 1973-07-11 1989-07-20 Hoechst Ag, 6230 Frankfurt 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE1911279A1 (de) * 1969-03-05 1970-11-12 Eckert Dr Theodor Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen
US4031218A (en) * 1976-04-28 1977-06-21 Mallinckrodt, Inc. 7-(2,3-Dihydroxypropyl-1,3-di-n-propylxanthine and a pharmaceutical composition containing same useful as a bronchial muscle relaxant
US4397779A (en) * 1978-08-09 1983-08-09 Baxter Travenol Laboratories, Inc. Preparation of xanthine tracers
IL59664A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
IT1195267B (it) * 1980-04-15 1988-10-12 Abc Ist Biolog Chem Spa Derivati teofillinmetildiossolanici,procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
AU554227B2 (en) 1986-08-14
ES8406479A1 (es) 1984-08-01
IE53911B1 (en) 1989-04-12
FI73681C (fi) 1987-11-09
FI823274A0 (fi) 1982-09-23
EP0075850A3 (en) 1983-07-27
ZA827012B (en) 1983-07-27
DE3138397A1 (de) 1983-04-07
IL66864A0 (en) 1982-12-31
JP2550301B2 (ja) 1996-11-06
DE3268041D1 (en) 1986-01-30
EP0075850B1 (de) 1985-12-18
ES528122A0 (es) 1984-08-01
KR840001576A (ko) 1984-05-07
US4713455A (en) 1987-12-15
HU186125B (en) 1985-06-28
NO158678C (no) 1988-10-19
IE822322L (en) 1983-03-26
DK148844C (da) 1986-03-17
AU8866382A (en) 1983-04-14
CA1286292C (en) 1991-07-16
DK426982A (da) 1983-03-27
PT75604B (de) 1985-07-26
JPS5867687A (ja) 1983-04-22
KR880002300B1 (ko) 1988-10-22
ES528123A0 (es) 1984-08-16
ES515936A0 (es) 1986-04-01
ES8606346A1 (es) 1986-04-01
FI823274L (fi) 1983-03-27
NO158678B (no) 1988-07-11
GR76734B (es) 1984-08-30
EP0075850A2 (de) 1983-04-06
NO823239L (no) 1983-03-28
FI73681B (fi) 1987-07-31
ATE17005T1 (de) 1986-01-15
DK148844B (da) 1985-10-21
PT75604A (de) 1982-10-01
US4616020A (en) 1986-10-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102