DK148844C - Analogifremgangsmaade til fremstilling af dihydroxyalkylsubstituerede xanthinderivater - Google Patents
Analogifremgangsmaade til fremstilling af dihydroxyalkylsubstituerede xanthinderivaterInfo
- Publication number
- DK148844C DK148844C DK426982A DK426982A DK148844C DK 148844 C DK148844 C DK 148844C DK 426982 A DK426982 A DK 426982A DK 426982 A DK426982 A DK 426982A DK 148844 C DK148844 C DK 148844C
- Authority
- DK
- Denmark
- Prior art keywords
- omega
- atoms
- xanthinder
- dihydroxyal
- analogy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/34—Halogenated alcohols
- C07C31/42—Polyhydroxylic acyclic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813138397 DE3138397A1 (de) | 1981-09-26 | 1981-09-26 | "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen" |
| DE3138397 | 1981-09-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK426982A DK426982A (da) | 1983-03-27 |
| DK148844B DK148844B (da) | 1985-10-21 |
| DK148844C true DK148844C (da) | 1986-03-17 |
Family
ID=6142714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK426982A DK148844C (da) | 1981-09-26 | 1982-09-24 | Analogifremgangsmaade til fremstilling af dihydroxyalkylsubstituerede xanthinderivater |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4616020A (es) |
| EP (1) | EP0075850B1 (es) |
| JP (1) | JP2550301B2 (es) |
| KR (1) | KR880002300B1 (es) |
| AT (1) | ATE17005T1 (es) |
| AU (1) | AU554227B2 (es) |
| CA (1) | CA1286292C (es) |
| DE (2) | DE3138397A1 (es) |
| DK (1) | DK148844C (es) |
| ES (3) | ES8606346A1 (es) |
| FI (1) | FI73681C (es) |
| GR (1) | GR76734B (es) |
| HU (1) | HU186125B (es) |
| IE (1) | IE53911B1 (es) |
| IL (1) | IL66864A0 (es) |
| NO (1) | NO158678C (es) |
| PT (1) | PT75604B (es) |
| ZA (1) | ZA827012B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636507A (en) * | 1984-04-30 | 1987-01-13 | Hoechst-Roussel Pharmaceuticals Inc. | Host defense mechanism enhancement |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| AU607709B2 (en) * | 1986-08-07 | 1991-03-14 | Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg | A micelle containing a hydrophobic pharmaceutically active substance |
| FR2611716A1 (fr) * | 1987-03-06 | 1988-09-09 | Uriach Cia Sa J | Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant |
| JP2661666B2 (ja) * | 1988-02-19 | 1997-10-08 | ヘキスト薬品工業株式会社 | 抗消化性潰瘍剤 |
| DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
| US5342841A (en) * | 1992-03-12 | 1994-08-30 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| US6469017B1 (en) * | 1998-01-16 | 2002-10-22 | Cell Therapeutics, Inc. | Method of inhibiting interleukin-12 signaling |
| US5473070A (en) * | 1992-11-16 | 1995-12-05 | Cell Therapeutics, Inc. | Substituted long chain alcohol xanthine compounds |
| GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| EP0799040B1 (en) * | 1994-12-13 | 2003-08-20 | Euroceltique S.A. | Trisubstituted thioxanthines |
| WO1996018399A1 (en) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Aryl thioxanthines |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| US6576619B2 (en) | 1999-05-24 | 2003-06-10 | Cv Therapeutics, Inc. | Orally active A1 adenosine receptor agonists |
| ES2215146T3 (es) * | 2000-09-08 | 2004-10-01 | Cv Therapeutics, Inc. | Utilizacion de ribosidos purina como antiarritmicos. |
| JP4483683B2 (ja) | 2005-04-28 | 2010-06-16 | 日立工機株式会社 | 連ねじドライバ |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2575344A (en) * | 1946-03-01 | 1951-11-20 | State Of Iowa | Dihydroxypropyl theophylline |
| US2517410A (en) * | 1947-08-15 | 1950-08-01 | Searle & Co | Hydroxy alkyl xanthines and the production thereof |
| DE2335170C2 (de) * | 1973-07-11 | 1989-07-20 | Hoechst Ag, 6230 Frankfurt | 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE1911279A1 (de) * | 1969-03-05 | 1970-11-12 | Eckert Dr Theodor | Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen |
| US4031218A (en) * | 1976-04-28 | 1977-06-21 | Mallinckrodt, Inc. | 7-(2,3-Dihydroxypropyl-1,3-di-n-propylxanthine and a pharmaceutical composition containing same useful as a bronchial muscle relaxant |
| US4397779A (en) * | 1978-08-09 | 1983-08-09 | Baxter Travenol Laboratories, Inc. | Preparation of xanthine tracers |
| IL59664A0 (en) * | 1979-04-05 | 1980-06-30 | Wuelfing J Kg | Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions |
| IT1195267B (it) * | 1980-04-15 | 1988-10-12 | Abc Ist Biolog Chem Spa | Derivati teofillinmetildiossolanici,procedimento per la loro preparazione e relative composizioni farmaceutiche |
-
1981
- 1981-09-26 DE DE19813138397 patent/DE3138397A1/de not_active Withdrawn
-
1982
- 1982-09-17 US US06/420,932 patent/US4616020A/en not_active Expired - Lifetime
- 1982-09-22 EP EP82108751A patent/EP0075850B1/de not_active Expired
- 1982-09-22 DE DE8282108751T patent/DE3268041D1/de not_active Expired
- 1982-09-22 AT AT82108751T patent/ATE17005T1/de not_active IP Right Cessation
- 1982-09-23 FI FI823274A patent/FI73681C/fi not_active IP Right Cessation
- 1982-09-23 PT PT75604A patent/PT75604B/pt unknown
- 1982-09-24 CA CA000412172A patent/CA1286292C/en not_active Expired - Fee Related
- 1982-09-24 ES ES515936A patent/ES8606346A1/es not_active Expired
- 1982-09-24 NO NO823239A patent/NO158678C/no unknown
- 1982-09-24 HU HU823086A patent/HU186125B/hu not_active IP Right Cessation
- 1982-09-24 DK DK426982A patent/DK148844C/da not_active IP Right Cessation
- 1982-09-24 JP JP57165147A patent/JP2550301B2/ja not_active Expired - Lifetime
- 1982-09-24 IE IE2322/82A patent/IE53911B1/en not_active IP Right Cessation
- 1982-09-24 GR GR69358A patent/GR76734B/el unknown
- 1982-09-24 AU AU88663/82A patent/AU554227B2/en not_active Ceased
- 1982-09-24 ZA ZA827012A patent/ZA827012B/xx unknown
- 1982-09-24 IL IL66864A patent/IL66864A0/xx not_active IP Right Cessation
- 1982-09-24 KR KR8204320A patent/KR880002300B1/ko active
-
1983
- 1983-12-16 ES ES528122A patent/ES528122A0/es active Granted
- 1983-12-16 ES ES528123A patent/ES8407048A1/es not_active Expired
-
1986
- 1986-04-04 US US06/848,139 patent/US4713455A/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |