KR880001301A - 지속성 약품 제제 - Google Patents
지속성 약품 제제 Download PDFInfo
- Publication number
- KR880001301A KR880001301A KR1019870007706A KR870007706A KR880001301A KR 880001301 A KR880001301 A KR 880001301A KR 1019870007706 A KR1019870007706 A KR 1019870007706A KR 870007706 A KR870007706 A KR 870007706A KR 880001301 A KR880001301 A KR 880001301A
- Authority
- KR
- South Korea
- Prior art keywords
- oil
- group
- long
- alcohol
- acting pharmaceutical
- Prior art date
Links
- 239000013583 drug formulation Substances 0.000 title claims 2
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 239000003921 oil Substances 0.000 claims 3
- 235000019198 oils Nutrition 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 239000001993 wax Substances 0.000 claims 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 claims 1
- FPXKNYVSOKOLKD-BTJKTKAUSA-N (z)-but-2-enedioic acid;n-chloroaniline Chemical compound OC(=O)\C=C/C(O)=O.ClNC1=CC=CC=C1 FPXKNYVSOKOLKD-BTJKTKAUSA-N 0.000 claims 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- RHLJLALHBZGAFM-UHFFFAOYSA-N Bunazosinum Chemical compound C1CN(C(=O)CCC)CCCN1C1=NC(N)=C(C=C(OC)C(OC)=C2)C2=N1 RHLJLALHBZGAFM-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 235000013871 bee wax Nutrition 0.000 claims 1
- 239000012166 beeswax Substances 0.000 claims 1
- 235000013869 carnauba wax Nutrition 0.000 claims 1
- 239000004203 carnauba wax Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940043348 myristyl alcohol Drugs 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- -1 paraffin) Chemical class 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims 1
- 229960000395 phenylpropanolamine Drugs 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 150000003445 sucroses Chemical class 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 238000004090 dissolution Methods 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1,2도는 본 발명에 의한 약품 제제로부터 약품의 용해 속도를, 대응하는 대조물로부터 동일한 약품의 용해속도와 비교하여 도표로서 각각 나타낸 것임.
Claims (5)
- 필수 성분으로서 수용성 약품, 지질 물질 및 오일로되는 지속성 약품 제제.
- 제1항에 있어서, 수용성 약품이 부나조신 염산염, 페닐프로판올아민, 클로르페닐아민 말레산염 및 테오필린으로 되는 군 중에서 선택된 약품 중의 적어도 하나인 것을 특징으로 하는 지속성 약품 제제.
- 제1항에 있어서, 지질 물질이 지방족 고급 지방산(예, 스테아르산, 미리스트산 및 팔미트산), 지방족 고급 알코올(예, 라우릴 알코올, 미리스틸 알코올 및 스테아릴 알코올), 고급 지방산의 에스테르(예, 글리세린과 수소첨가 피마자유의 모노스테아레이트, 디스테아레이트 및 트리스레아테이트), 왁스(예, 밀랍, 카르나우바 왁스, 일본 왁스 및 경랍), 및 탄화수소(예, 파라핀), 미세결정성 왁스 및 세레신, 및 지상산의 슈크로오스 에스테르로 되는 군 중에서 선택된 물질 중의 적어도 하나인 것을 특징으로 하는 지속성 약품 제제.
- 제1항에 있어서, 오일이 대두유, 면실유, 참깨유, 땅콩유, 올리브유, 해바라기유, 옥틸도데실 글리세리드, 미그리올, 글리세린, 모노카프릴레이트, 실리콘 오일로 되는 군 중에서 선택된 오일중의 적어도 하나인 것을 특징으로 하는 지속성 약품 제제.
- 제1항에 있어서, 제제가 정제 또는 과립제의 형태인 것을 특징으로 하는 지속성 약품 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61-167,865 | 1986-07-18 | ||
JP61167865A JPH0816066B2 (ja) | 1986-07-18 | 1986-07-18 | 持続性薬効製剤 |
JP167865 | 1986-07-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880001301A true KR880001301A (ko) | 1988-04-22 |
KR960004857B1 KR960004857B1 (ko) | 1996-04-16 |
Family
ID=15857516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870007706A KR960004857B1 (ko) | 1986-07-18 | 1987-07-16 | 지속성 약제 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5030455A (ko) |
EP (1) | EP0254978B1 (ko) |
JP (1) | JPH0816066B2 (ko) |
KR (1) | KR960004857B1 (ko) |
AT (1) | ATE71291T1 (ko) |
CA (1) | CA1309656C (ko) |
DE (1) | DE3775850D1 (ko) |
DK (1) | DK174931B1 (ko) |
ES (1) | ES2040228T3 (ko) |
FI (1) | FI96095C (ko) |
GR (1) | GR3003536T3 (ko) |
NO (1) | NO179163C (ko) |
PH (1) | PH25286A (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030024191A (ko) * | 2001-09-17 | 2003-03-26 | 주식회사 효성 | 알칼리 가용성 코폴리에스터 및 이의 제조방법 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01308232A (ja) * | 1988-06-03 | 1989-12-12 | Takeda Chem Ind Ltd | 固型医薬およびその製造法 |
US4975312A (en) * | 1988-06-20 | 1990-12-04 | Foster-Miller, Inc. | Multiaxially oriented thermotropic polymer substrate for printed wire board |
JP2681373B2 (ja) * | 1988-07-18 | 1997-11-26 | 塩野義製薬株式会社 | 徐放性製剤の製造法 |
JP2794022B2 (ja) * | 1988-11-11 | 1998-09-03 | 三生製薬株式会社 | ブナゾシン或いはその塩類含有経皮適用製剤 |
JP3195391B2 (ja) * | 1991-11-14 | 2001-08-06 | エスエス製薬株式会社 | 徐放性トラピジル錠 |
GB2263910A (en) * | 1992-02-05 | 1993-08-11 | Co Ordinated Drug Dev | Direct compression tablet excipient |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
CN1103586C (zh) * | 1993-12-13 | 2003-03-26 | 里达克药品公司 | 蔗糖酯-c20-28醇制剂 |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
JPH08143450A (ja) * | 1994-11-14 | 1996-06-04 | Taiyo Yakuhin Kogyo Kk | 徐放化製剤 |
CA2233016C (en) * | 1995-09-25 | 2007-07-17 | Ashmont Holdings Limited | Anthelmintic macrocyclic lactone compositions |
US6417326B1 (en) | 1996-04-11 | 2002-07-09 | The University Of British Columbia | Fusogenic liposomes |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
AU2002351008B2 (en) * | 2001-11-30 | 2007-07-12 | Pfizer Products Inc. | Pharmaceutical compositions of 5,8,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]-hexadeca-2(11)3,5,7,9-pentaene |
US20040096498A1 (en) * | 2002-04-29 | 2004-05-20 | Alvin Kershman | Oral pharmaceutical delivery system with improved sustained release |
EP2650065A4 (en) * | 2010-12-08 | 2014-06-04 | Aida Eng Ltd | METHOD FOR THE PRODUCTION OF HIGH-DEFINED SINTERING PRESSURE RINGS AND DEVICE FOR THEIR PRODUCTION |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2895881A (en) * | 1957-04-04 | 1959-07-21 | Wynn Pharmacal Corp | Quinidine gluconate sustained medication tablet |
CH415963A (de) * | 1964-09-04 | 1966-06-30 | Wander Ag Dr A | Masse zur Herstellung von Tabletten mit protrahierter Wirkung |
US3655864A (en) * | 1970-09-21 | 1972-04-11 | Smith Kline French Lab | Glyceryl tristerate and higher fatty acid mixture for improving digestive absorption |
US4020159A (en) * | 1974-10-08 | 1977-04-26 | Apotheker A. Herbert K.G., Fabrik Pharmazeutischer Praparate Wiesbaden | Methods of and medications for treating cardiac disorders by using strophanthin |
US4163777A (en) * | 1977-04-29 | 1979-08-07 | Lewis/Howe Company | Controlled antacid delivery form and method of treatment therewith |
US4375468A (en) * | 1981-07-13 | 1983-03-01 | Verex Laboratories, Inc. | Constant order release aspirin composition and method of treating arthritis |
JPS6143108A (ja) * | 1984-08-03 | 1986-03-01 | Nippon Shinyaku Co Ltd | 医薬品製剤及びその製造法 |
EP0176772B1 (de) * | 1984-08-30 | 1989-03-29 | RODISMA Pharmazeutische Produkte GmbH | Verfahren zur Retardierung von Vitamin C und E |
-
1986
- 1986-07-18 JP JP61167865A patent/JPH0816066B2/ja not_active Expired - Lifetime
-
1987
- 1987-07-14 FI FI873106A patent/FI96095C/fi not_active IP Right Cessation
- 1987-07-16 AT AT87110297T patent/ATE71291T1/de not_active IP Right Cessation
- 1987-07-16 DE DE8787110297T patent/DE3775850D1/de not_active Expired - Lifetime
- 1987-07-16 EP EP87110297A patent/EP0254978B1/en not_active Expired - Lifetime
- 1987-07-16 ES ES198787110297T patent/ES2040228T3/es not_active Expired - Lifetime
- 1987-07-16 KR KR1019870007706A patent/KR960004857B1/ko not_active IP Right Cessation
- 1987-07-17 CA CA000542420A patent/CA1309656C/en not_active Expired - Lifetime
- 1987-07-17 DK DK198703731A patent/DK174931B1/da not_active IP Right Cessation
- 1987-07-17 PH PH8735554A patent/PH25286A/en unknown
- 1987-07-17 NO NO872991A patent/NO179163C/no not_active IP Right Cessation
-
1989
- 1989-08-22 US US07/396,838 patent/US5030455A/en not_active Expired - Lifetime
-
1992
- 1992-01-09 GR GR910401578T patent/GR3003536T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030024191A (ko) * | 2001-09-17 | 2003-03-26 | 주식회사 효성 | 알칼리 가용성 코폴리에스터 및 이의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
NO179163C (no) | 1996-08-21 |
DK373187D0 (da) | 1987-07-17 |
CA1309656C (en) | 1992-11-03 |
EP0254978A1 (en) | 1988-02-03 |
DK174931B1 (da) | 2004-03-01 |
PH25286A (en) | 1991-04-30 |
KR960004857B1 (ko) | 1996-04-16 |
DK373187A (da) | 1988-01-19 |
EP0254978B1 (en) | 1992-01-08 |
FI873106A (fi) | 1988-01-19 |
FI96095B (fi) | 1996-01-31 |
NO179163B (no) | 1996-05-13 |
NO872991L (no) | 1988-01-19 |
DE3775850D1 (de) | 1992-02-20 |
FI96095C (fi) | 1996-05-10 |
ES2040228T3 (es) | 1993-10-16 |
GR3003536T3 (ko) | 1993-03-16 |
JPH0816066B2 (ja) | 1996-02-21 |
JPS6327439A (ja) | 1988-02-05 |
US5030455A (en) | 1991-07-09 |
FI873106A0 (fi) | 1987-07-14 |
ATE71291T1 (de) | 1992-01-15 |
NO872991D0 (no) | 1987-07-17 |
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