KR880000765B1 - Process for the preparation of polypetide - Google Patents

Process for the preparation of polypetide

Info

Publication number
KR880000765B1
KR880000765B1 KR8508213A KR850008213A KR880000765B1 KR 880000765 B1 KR880000765 B1 KR 880000765B1 KR 8508213 A KR8508213 A KR 8508213A KR 850008213 A KR850008213 A KR 850008213A KR 880000765 B1 KR880000765 B1 KR 880000765B1
Authority
KR
South Korea
Prior art keywords
amino acid
polypeptide
polypetide
preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8508213A
Other languages
English (en)
Korean (ko)
Other versions
KR860004081A (ko
Inventor
Hiroshi Yoshino
Yudaka Tsuchiya
Dakeru Kameko
Dakahiro Nakajawa
Mashiro Ikeda
Shin Araki
Kiyomi Yamatsu
Shinro Datsibana
Yoshihiro Arakawa
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of KR860004081A publication Critical patent/KR860004081A/ko
Application granted granted Critical
Publication of KR880000765B1 publication Critical patent/KR880000765B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR8508213A 1984-11-09 1985-11-04 Process for the preparation of polypetide Expired KR880000765B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59-236076 1984-11-09
JP59236076A JPH0680079B2 (ja) 1984-11-09 1984-11-09 ポリペプチド

Publications (2)

Publication Number Publication Date
KR860004081A KR860004081A (ko) 1986-06-16
KR880000765B1 true KR880000765B1 (en) 1988-05-06

Family

ID=16995360

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8508213A Expired KR880000765B1 (en) 1984-11-09 1985-11-04 Process for the preparation of polypetide

Country Status (21)

Country Link
US (1) US4707468A (enExample)
EP (2) EP0614913A3 (enExample)
JP (1) JPH0680079B2 (enExample)
KR (1) KR880000765B1 (enExample)
CN (1) CN1029684C (enExample)
AT (1) ATE135712T1 (enExample)
AU (1) AU588837B2 (enExample)
CA (1) CA1267997A (enExample)
DE (1) DE3588095T2 (enExample)
DK (1) DK171300B1 (enExample)
ES (1) ES8800272A1 (enExample)
FI (1) FI92935C (enExample)
GR (1) GR852689B (enExample)
HU (1) HU203563B (enExample)
IL (1) IL76924A (enExample)
NO (1) NO169347C (enExample)
NZ (1) NZ214122A (enExample)
PH (1) PH23847A (enExample)
PT (1) PT81441B (enExample)
SU (1) SU1433415A3 (enExample)
ZA (1) ZA858456B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2673376A1 (fr) * 1991-03-01 1992-09-04 Lefesvre Andre Composition pharmaceutique pour le traitement des tumeurs de kaposi.
US5817628A (en) * 1992-12-02 1998-10-06 The Rockefeller University Dynorphin a suppression of natural killer cell activity
SE9401596D0 (sv) * 1994-05-06 1994-05-06 Astra Ab New compounds
JP3385147B2 (ja) * 1996-01-31 2003-03-10 ユニ・チャーム株式会社 男性用尿とり袋
WO1997049422A1 (en) * 1996-06-24 1997-12-31 The Rockefeller University Method of using ligands of the kappa opioid receptor
EP1950224A3 (en) * 1998-03-09 2008-12-17 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US6232287B1 (en) * 1998-03-13 2001-05-15 The Burnham Institute Molecules that home to various selected organs or tissues
IL137820A (en) * 2000-08-10 2009-06-15 S I S Shulov Inst For Science Pharmaceutical composition for topical administration comprising an analgesic peptide
AU2001286763C1 (en) * 2000-08-25 2006-03-02 Research Corporation Technologies, Inc. New uses for amino acid anticonvulsants for treatment of pain
PT1243262E (pt) * 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
DE60100055T2 (de) * 2001-03-21 2003-07-24 Schwarz Pharma Ag Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
US7622446B2 (en) * 2001-04-18 2009-11-24 The Open University Polypeptides, derivatives and uses thereof
US7491702B2 (en) * 2001-04-18 2009-02-17 The Open University Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
KR20070007931A (ko) 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EA014055B1 (ru) * 2004-08-27 2010-08-30 Шварц Фарма Аг Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
GB2432586B (en) * 2005-11-25 2010-01-13 Univ Open Treatment of neurodegenerative disorders
WO2007144195A2 (en) 2006-06-15 2007-12-21 Schwarz Pharma Ag Pharmaceutical composition with synergistic anticonvulsant effect
KR20100057050A (ko) * 2007-09-11 2010-05-28 몬도바이오테크 래보래토리즈 아게 치료제로서의 데슬로렐린 및 마스토파란의 용도
KR20100056517A (ko) * 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
EP4092038A1 (en) 2017-09-11 2022-11-23 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
WO2022000043A1 (en) * 2020-07-01 2022-01-06 PreveCeutical Medical Inc. Peptides and uses thereof
RU2760133C1 (ru) * 2021-04-22 2021-11-22 Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства". Амиды гептапептида для лечения HMGB1-зависимых заболеваний

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254106A (en) * 1976-01-26 1981-03-03 Burroughs Wellcome Co. Biologically active amides
ES455365A1 (es) * 1976-01-26 1978-05-16 Wellcome Found Un metodo de preparacion de un peptido dotado de actividad biologica analoga a la de la morfina.
US4123523A (en) * 1976-06-21 1978-10-31 Imperial Chemical Industries Limited Analgesic and sedative polypeptides
US4371463A (en) * 1977-02-17 1983-02-01 The United States Of America As Represented By The Department Of Health And Human Services Enzyme-resistant opiate pentapeptides
US4081434A (en) * 1977-03-11 1978-03-28 Hoffmann-La Roche Inc. Novel analogs of β-endorphin
US4139504A (en) * 1977-06-16 1979-02-13 Coy David Howard Novel nonapeptides, intermediates therefor, and compositions and methods employing said nonapeptides
US4127533A (en) * 1977-06-16 1978-11-28 Coy David Howard Novel octapeptides, intermediates therefor, and compositions and methods employing said octapeptides
GB1604850A (en) * 1977-11-24 1981-12-16 Wellcome Found Biologically active peptides
US4148786A (en) * 1978-06-26 1979-04-10 American Home Products Corporation Analgesic polypeptide
US4178284A (en) * 1978-12-11 1979-12-11 American Home Products Corporation Octapeptides
DE2936099A1 (de) * 1979-09-06 1981-04-02 Victor Dipl.- Chem. 8000 München Brantl Pharmakologisch aktive peptide
DE3163199D1 (en) * 1980-07-17 1984-05-24 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
JPS57134451A (en) * 1981-02-13 1982-08-19 Suntory Ltd Peptide opioide
EP0076676B1 (en) * 1981-10-05 1986-12-30 Tni Pharmaceuticals, Inc. Process for using endorphins as antitumour agents
US4462941A (en) * 1982-06-10 1984-07-31 The Regents Of The University Of California Dynorphin amide analogs
JPS59141547A (ja) * 1983-02-01 1984-08-14 Eisai Co Ltd 鎮痛作用を有する新規ペプタイドおよび製法
US4518711A (en) * 1983-05-16 1985-05-21 Gibson-Stephens Institute Conformationally constrained cyclic enkephalin analogs with delta receptor specificity

Also Published As

Publication number Publication date
US4707468A (en) 1987-11-17
NO169347C (no) 1992-06-10
FI854227L (fi) 1986-05-10
SU1433415A3 (ru) 1988-10-23
DK171300B1 (da) 1996-08-26
NZ214122A (en) 1988-08-30
ES548667A0 (es) 1987-10-16
JPH0680079B2 (ja) 1994-10-12
EP0181001B1 (en) 1996-03-20
AU588837B2 (en) 1989-09-28
PH23847A (en) 1989-11-23
CA1267997A (en) 1990-04-17
FI92935B (fi) 1994-10-14
ES8800272A1 (es) 1987-10-16
IL76924A0 (en) 1986-04-29
DK513385D0 (da) 1985-11-07
NO169347B (no) 1992-03-02
EP0181001A2 (en) 1986-05-14
FI854227A0 (fi) 1985-10-28
CN85109722A (zh) 1986-10-08
ZA858456B (en) 1987-07-29
EP0614913A3 (en) 1997-06-04
CN1029684C (zh) 1995-09-06
NO854435L (no) 1986-05-12
ATE135712T1 (de) 1996-04-15
HUT40145A (en) 1986-11-28
PT81441A (en) 1985-12-01
DE3588095D1 (de) 1996-04-25
JPS61115097A (ja) 1986-06-02
GR852689B (enExample) 1986-02-21
FI92935C (fi) 1995-01-25
HU203563B (en) 1991-08-28
EP0181001A3 (en) 1989-04-19
DE3588095T2 (de) 1996-09-19
IL76924A (en) 1990-07-12
DK513385A (da) 1986-05-10
PT81441B (pt) 1987-11-11
EP0614913A2 (en) 1994-09-14
KR860004081A (ko) 1986-06-16
AU4938985A (en) 1986-05-15

Similar Documents

Publication Publication Date Title
KR880000765B1 (en) Process for the preparation of polypetide
EP0132732A3 (en) Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments
DE69114503D1 (de) Verfahren zur in-line-hydrolyse von harnstoff.
DE3280014D1 (en) Derivatives of bicyclic amino acids, processes for their preparation, agents containing them and their use as well as bicyclic amino acids as intermediates and process for their preparation
EP0185390A3 (en) Tripeptidyl-argininaldehyde, process for its preparation and medicaments thereof, as well as n-(monoalkyl) and n,n-di-(alkyl)-xxx-l-proline dipeptide
EP0089637A3 (en) Bicyclic amino acid derivatives, process for their preparation, agents containing them and their application, bicyclic amino acids as intermediates, and process for their preparation
AU6112790A (en) N-(substituted benzyloxy)imine derivatives, process for the production thereof, use thereof, and method of use thereof
EG19583A (en) Process for preparing pharmaceutical composition from chymopapain
YU41999B (en) Process for the elimination of urea, ammonia and carbon dioxide from diluted aqueous solution
EP0288959A3 (en) Novel glycoprotein, production process thereof and immunosuppressive agent containing same as effective ingredient
HUT44042A (en) Process for preparing renin inhibitor peptides, amino acid and aminoaldehyde derivatives, as well as pharmaceuticals comprising renin inhibitor peptides
EP0155786A3 (en) New peptide, and production and use thereof
AU579593B2 (en) Novel peptides which are active on the central nervous system and have an action on the cholinergic system
EP0225020A3 (en) Peptides comprising, in sequence, units selected from the amino-acid residues 17 to 24 of vip
ZA84439B (en) Amino acid derivatives,process for their preparation and pharmaceutical preparations containing them
AU570572B2 (en) 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl) amino)-3- furancarboxylic acid derivatives
MX9704973A (es) Proceso para la preparacion de esteres de celulosa utilizando un catalizador de resina de acido sulfonico.
FR2544303B1 (fr) Composition durcissable, procede de mise en oeuvre de celle-ci et application notamment au colmatage d'orifices
DK0651791T3 (da) Fremgangsmåde til oprensning af vandig enzymopløsning
IL85168A0 (en) Process for the manufacture of n,n-(dibenzohexatrienylene)ureas
AU582416B2 (en) Polypeptide secretion-causing vector, microorganisms transformed by said vector, and process for preparing polypeptide using said microorganisms
SG64917A1 (en) Method of peptide synthesis and new synthesis intermediates
FR2548232B1 (fr) Nouveau precondensat, dispersion aqueuse stable de precondensat, et son utilisation dans un procede de post-traitement de substrats contenant des groupes hydroxy, amino ou thiol
GR3000946T3 (en) N,n'-disubstituted ureas and process for their production
AU586352B2 (en) Process for concentration of an aqueous solution of amino acid

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 13

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 14

FPAY Annual fee payment

Payment date: 20020502

Year of fee payment: 15

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 15

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20030507

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20030507

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000