JPS57134451A - Peptide opioide - Google Patents
Peptide opioideInfo
- Publication number
- JPS57134451A JPS57134451A JP56020707A JP2070781A JPS57134451A JP S57134451 A JPS57134451 A JP S57134451A JP 56020707 A JP56020707 A JP 56020707A JP 2070781 A JP2070781 A JP 2070781A JP S57134451 A JPS57134451 A JP S57134451A
- Authority
- JP
- Japan
- Prior art keywords
- fraction
- tyr
- leu
- gly
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:Peptide opioide of formulaI[Tyr is tyrosine; Gly is glycine; Phe is phenylalanine; Leu is leucine residue; R is formula II (Arg is arginine; LyS is lysine; Pro is proline), formula III (Ile is isoleucine) which is connected to the terminal of Leu].
EXAMPLE: Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro.
USE: Morphine-like analgesic.
PREPARATION: Pig hypothalamus, after defatted, is extracted with acetic acid to collect the low-molecular fraction. Then, G-fraction is collected from the basic fraction eluted with ammonia as a fraction eluting before α-neo-endorphin and subjected to gel filtration. The eluate is subjected to high-speed liquid chromatography to effect purification and β-neo-endorphin and pH-8P are obtained from the selected two peaks where R is formula II of the formulaIin the former and R is formula III in the latter.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56020707A JPS57134451A (en) | 1981-02-13 | 1981-02-13 | Peptide opioide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56020707A JPS57134451A (en) | 1981-02-13 | 1981-02-13 | Peptide opioide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57134451A true JPS57134451A (en) | 1982-08-19 |
JPH0159279B2 JPH0159279B2 (en) | 1989-12-15 |
Family
ID=12034611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56020707A Granted JPS57134451A (en) | 1981-02-13 | 1981-02-13 | Peptide opioide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57134451A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61115097A (en) * | 1984-11-09 | 1986-06-02 | Eisai Co Ltd | Polypeptide |
CN113624898A (en) * | 2021-08-23 | 2021-11-09 | 成都诺和晟泰生物科技有限公司 | Purification method of chiral analgesic polypeptide drug |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH043458U (en) * | 1990-04-24 | 1992-01-13 |
-
1981
- 1981-02-13 JP JP56020707A patent/JPS57134451A/en active Granted
Non-Patent Citations (2)
Title |
---|
BIOCHEM BIOPHYS RES COMMUN * |
PEPT CHEM * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61115097A (en) * | 1984-11-09 | 1986-06-02 | Eisai Co Ltd | Polypeptide |
CN113624898A (en) * | 2021-08-23 | 2021-11-09 | 成都诺和晟泰生物科技有限公司 | Purification method of chiral analgesic polypeptide drug |
CN113624898B (en) * | 2021-08-23 | 2023-08-25 | 成都诺和晟泰生物科技有限公司 | Purification method of chiral analgesic polypeptide medicine |
Also Published As
Publication number | Publication date |
---|---|
JPH0159279B2 (en) | 1989-12-15 |
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