JPS57134451A - Peptide opioide - Google Patents

Peptide opioide

Info

Publication number
JPS57134451A
JPS57134451A JP56020707A JP2070781A JPS57134451A JP S57134451 A JPS57134451 A JP S57134451A JP 56020707 A JP56020707 A JP 56020707A JP 2070781 A JP2070781 A JP 2070781A JP S57134451 A JPS57134451 A JP S57134451A
Authority
JP
Japan
Prior art keywords
fraction
tyr
leu
gly
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56020707A
Other languages
Japanese (ja)
Other versions
JPH0159279B2 (en
Inventor
Toshiyuki Matsuo
Kenji Sagawa
Naoto Minamino
Kensaku Mizuno
Yujiro Hayashi
Shunpei Sakakibara
Naoyoshi Kayano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUNTORY KK
Suntory Ltd
Original Assignee
SUNTORY KK
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUNTORY KK, Suntory Ltd filed Critical SUNTORY KK
Priority to JP56020707A priority Critical patent/JPS57134451A/en
Publication of JPS57134451A publication Critical patent/JPS57134451A/en
Publication of JPH0159279B2 publication Critical patent/JPH0159279B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:Peptide opioide of formulaI[Tyr is tyrosine; Gly is glycine; Phe is phenylalanine; Leu is leucine residue; R is formula II (Arg is arginine; LyS is lysine; Pro is proline), formula III (Ile is isoleucine) which is connected to the terminal of Leu].
EXAMPLE: Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro.
USE: Morphine-like analgesic.
PREPARATION: Pig hypothalamus, after defatted, is extracted with acetic acid to collect the low-molecular fraction. Then, G-fraction is collected from the basic fraction eluted with ammonia as a fraction eluting before α-neo-endorphin and subjected to gel filtration. The eluate is subjected to high-speed liquid chromatography to effect purification and β-neo-endorphin and pH-8P are obtained from the selected two peaks where R is formula II of the formulaIin the former and R is formula III in the latter.
COPYRIGHT: (C)1982,JPO&Japio
JP56020707A 1981-02-13 1981-02-13 Peptide opioide Granted JPS57134451A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56020707A JPS57134451A (en) 1981-02-13 1981-02-13 Peptide opioide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56020707A JPS57134451A (en) 1981-02-13 1981-02-13 Peptide opioide

Publications (2)

Publication Number Publication Date
JPS57134451A true JPS57134451A (en) 1982-08-19
JPH0159279B2 JPH0159279B2 (en) 1989-12-15

Family

ID=12034611

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56020707A Granted JPS57134451A (en) 1981-02-13 1981-02-13 Peptide opioide

Country Status (1)

Country Link
JP (1) JPS57134451A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61115097A (en) * 1984-11-09 1986-06-02 Eisai Co Ltd Polypeptide
CN113624898A (en) * 2021-08-23 2021-11-09 成都诺和晟泰生物科技有限公司 Purification method of chiral analgesic polypeptide drug

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH043458U (en) * 1990-04-24 1992-01-13

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEM BIOPHYS RES COMMUN *
PEPT CHEM *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61115097A (en) * 1984-11-09 1986-06-02 Eisai Co Ltd Polypeptide
CN113624898A (en) * 2021-08-23 2021-11-09 成都诺和晟泰生物科技有限公司 Purification method of chiral analgesic polypeptide drug
CN113624898B (en) * 2021-08-23 2023-08-25 成都诺和晟泰生物科技有限公司 Purification method of chiral analgesic polypeptide medicine

Also Published As

Publication number Publication date
JPH0159279B2 (en) 1989-12-15

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