KR870700095A - AraB 프로모터 및 미생물학적 방법에 의해 세크로핀을 포함한 폴리펩타이드를 제조하는 방법 - Google Patents
AraB 프로모터 및 미생물학적 방법에 의해 세크로핀을 포함한 폴리펩타이드를 제조하는 방법Info
- Publication number
- KR870700095A KR870700095A KR1019860700669A KR860700669A KR870700095A KR 870700095 A KR870700095 A KR 870700095A KR 1019860700669 A KR1019860700669 A KR 1019860700669A KR 860700669 A KR860700669 A KR 860700669A KR 870700095 A KR870700095 A KR 870700095A
- Authority
- KR
- South Korea
- Prior art keywords
- cecropin
- host
- polypeptide
- transformed
- genetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 20
- 108050004290 Cecropin Proteins 0.000 title claims 18
- 229920001184 polypeptide Polymers 0.000 title claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 12
- 238000000034 method Methods 0.000 title claims 3
- 238000013048 microbiological method Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 11
- 241000894006 Bacteria Species 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000002068 genetic effect Effects 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 claims 6
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 101150076489 B gene Proteins 0.000 claims 1
- 101800003223 Cecropin-A Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 108700032080 Hyalophora cecropia cecropin D Proteins 0.000 claims 1
- 108700022013 Insecta cecropin B Proteins 0.000 claims 1
- -1 antibodies Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000000721 bacterilogical effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- HCQPHKMLKXOJSR-IRCPFGJUSA-N cecropin-a Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C1=CC=CC=C1 HCQPHKMLKXOJSR-IRCPFGJUSA-N 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000013587 production medium Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 241001515965 unidentified phage Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69530985A | 1985-01-28 | 1985-01-28 | |
| US79747285A | 1985-11-13 | 1985-11-13 | |
| US695309 | 1985-11-13 | ||
| US797472 | 1985-11-13 | ||
| PCT/US1986/000131 WO1986004356A1 (en) | 1985-01-28 | 1986-01-24 | AraB PROMOTERS AND METHOD OF PRODUCING POLYPEPTIDES, INCLUDINN CECROPINS, BY MICROBIOLOGICAL TECHNIQUES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR870700095A true KR870700095A (ko) | 1987-02-28 |
Family
ID=27105550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860700669A Ceased KR870700095A (ko) | 1985-01-28 | 1986-01-24 | AraB 프로모터 및 미생물학적 방법에 의해 세크로핀을 포함한 폴리펩타이드를 제조하는 방법 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP0460709B1 (enExample) |
| JP (2) | JPH082308B2 (enExample) |
| KR (1) | KR870700095A (enExample) |
| AT (2) | ATE101203T1 (enExample) |
| DE (2) | DE3650625T2 (enExample) |
| FI (1) | FI94774C (enExample) |
| NO (1) | NO175870C (enExample) |
| WO (1) | WO1986004356A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028530A (en) * | 1985-01-28 | 1991-07-02 | Xoma Corporation | AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques |
| US5166321A (en) * | 1985-01-28 | 1992-11-24 | International Genetic Engineering, Inc. | Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria |
| US5597945A (en) * | 1986-07-25 | 1997-01-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Plants genetically enhanced for disease resistance |
| DE3751338T2 (de) * | 1986-07-25 | 1995-11-23 | Univ Louisiana State | Verfahren zum verleihen bei pflanzen eines widerstands gegen krankheiten und pest sowie neue gene in pflanzen die hierfür kodieren. |
| DE3716957A1 (de) * | 1987-05-20 | 1988-12-01 | Boehringer Mannheim Gmbh | Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten |
| DE3854476T2 (de) * | 1987-07-06 | 1996-04-04 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| US5861478A (en) * | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| CA1327311C (en) | 1987-07-06 | 1994-03-01 | Jesse M. Jaynes | Therapeutic antimicrobial polypeptides, their use and methods for preparation |
| EP0326419A3 (en) * | 1988-01-27 | 1991-09-25 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF AGRICULTURE | Vaccines for the protection of animals against hypodermosis |
| US5631007A (en) * | 1990-03-12 | 1997-05-20 | Ciba-Geigy Corporation | Anti-pathogenically effective compositions comprising lytic peptides and hydrolytic enzymes |
| PH30997A (en) * | 1990-03-12 | 1997-12-23 | Ciba Geigy | Antipathologenically effective compositions comprising lytic peptides and hydrolytic enzymes. |
| IL114697A0 (en) * | 1994-07-22 | 1995-11-27 | Demeter Biotech Ltd | Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use |
| US5589364A (en) * | 1994-07-29 | 1996-12-31 | Magainin Pharmaceuticals Inc. | Recombinant production of biologically active peptides and proteins |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6030807A (en) * | 1996-09-10 | 2000-02-29 | The Rockefeller University | Highly regulable promoter for heterologous gene expression |
| AU2001242432B2 (en) | 2000-02-24 | 2007-11-08 | Eidgenossische Technische Hochschule Zurich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| EP1824980B1 (en) | 2004-12-07 | 2010-04-28 | Lonza Ag | Rhamnose promoter expression system |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| CN120154716A (zh) | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| JP7774961B2 (ja) | 2018-02-06 | 2025-11-25 | シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート | フルオレセイン結合エーテルリン脂質（ｆｌ－ｐｌｅ）で標識された腫瘍に対して最適なｔ細胞機能を示すフルオレセイン特異的ｃａｒ |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| CN112575047B (zh) * | 2020-12-29 | 2024-06-21 | 中农颖泰林州生物科园有限公司 | 一种提高饲料用的抗菌肽天蚕素收率的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366246A (en) | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US4335104A (en) * | 1978-08-16 | 1982-06-15 | United Chemical Corporation | Anhydrous multi-purpose moisturizing composition |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US4355104A (en) | 1980-06-17 | 1982-10-19 | Kabigen Ab | Bacteriolytic proteins |
| US4520016A (en) * | 1980-06-17 | 1985-05-28 | Kabigen Ab | Bacteriolytic proteins |
| IL68561A (en) | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
| WO1985001746A1 (en) | 1983-10-11 | 1985-04-25 | Beatrice Companies, Inc. | The manufacture and expression of genes for thaumatin |
-
1986
- 1986-01-24 DE DE3650625T patent/DE3650625T2/de not_active Expired - Fee Related
- 1986-01-24 KR KR1019860700669A patent/KR870700095A/ko not_active Ceased
- 1986-01-24 EP EP91112901A patent/EP0460709B1/en not_active Expired - Lifetime
- 1986-01-24 DE DE3689598T patent/DE3689598T2/de not_active Expired - Lifetime
- 1986-01-24 EP EP86900983A patent/EP0211047B1/en not_active Expired - Lifetime
- 1986-01-24 AT AT86900983T patent/ATE101203T1/de not_active IP Right Cessation
- 1986-01-24 AT AT91112901T patent/ATE153377T1/de not_active IP Right Cessation
- 1986-01-24 JP JP61500818A patent/JPH082308B2/ja not_active Expired - Lifetime
- 1986-01-24 WO PCT/US1986/000131 patent/WO1986004356A1/en not_active Ceased
- 1986-09-24 NO NO863806A patent/NO175870C/no unknown
- 1986-09-26 FI FI863891A patent/FI94774C/fi not_active IP Right Cessation
-
1994
- 1994-05-09 JP JP6094753A patent/JPH0829112B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1986004356A1 (en) | 1986-07-31 |
| NO175870C (no) | 1994-12-21 |
| NO863806L (no) | 1986-11-19 |
| EP0460709A1 (en) | 1991-12-11 |
| EP0211047B1 (en) | 1994-02-02 |
| EP0211047A4 (en) | 1989-04-24 |
| DE3689598T2 (de) | 1994-06-30 |
| JPH0767684A (ja) | 1995-03-14 |
| FI94774C (fi) | 1995-10-25 |
| FI863891A0 (fi) | 1986-09-26 |
| JPS62501538A (ja) | 1987-06-25 |
| DE3650625T2 (de) | 1997-10-02 |
| EP0460709B1 (en) | 1997-05-21 |
| JPH082308B2 (ja) | 1996-01-17 |
| DE3650625D1 (de) | 1997-06-26 |
| ATE101203T1 (de) | 1994-02-15 |
| NO175870B (enExample) | 1994-09-12 |
| EP0211047A1 (en) | 1987-02-25 |
| FI863891L (fi) | 1986-09-26 |
| ATE153377T1 (de) | 1997-06-15 |
| FI94774B (fi) | 1995-07-14 |
| DE3689598D1 (de) | 1994-03-17 |
| NO863806D0 (no) | 1986-09-24 |
| JPH0829112B2 (ja) | 1996-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19860929 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19870928 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19860929 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19900430 Patent event code: PE09021S01D |
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