KR870001231A - 치환된 디-t-부틸페놀의 제조 방법 - Google Patents

치환된 디-t-부틸페놀의 제조 방법 Download PDF

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KR870001231A
KR870001231A KR1019860005889A KR860005889A KR870001231A KR 870001231 A KR870001231 A KR 870001231A KR 1019860005889 A KR1019860005889 A KR 1019860005889A KR 860005889 A KR860005889 A KR 860005889A KR 870001231 A KR870001231 A KR 870001231A
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alkyl
compound
mammal
butyl
carboxy
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KR1019860005889A
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KR910002371B1 (ko
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에이. 쉘러 로버트
에이. 쉘터 로버트
에이. 러스태드 마크
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라이커 래보러토리스, 인코오포레이티드
윌리암 조오지 메레디스
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Publication of KR870001231A publication Critical patent/KR870001231A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
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  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

치환된 디-t-부틸페놀의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기식(I)의 화합물, A가 카르복실일 때 카르복시부의 저급 카르복실레이트 에스테르, (저급)알킬아미노(저급)알킬 카르복실레이트 에스테르, 약학적 허용(저급)알킬 아미노(저급) 알킬 카르복실레이트 에스테르산-부가염 및 약학적 허용 카르복실레이트 염으로부터 선택된 유도체 또는 A가 테트라졸릴 일 때 테트라졸릴 부의 약학적 허용 알칼리 금속 및 알칼리 토금속 염으로부터 선택된 유도체.
    상기식에서, R은 각각, 수소, 저급알킬, 저급알콕시, 할로겐(툭히, Cl, F), 아미노, 저급 알킬아미노, 저급디알킬 아미노, 히드록시, 저급 아실아미도, 트리플루오로 메틸, 벤조일옥시, 카르복시, 또는 R이 저급알킬 카르복실레이트 에스테르, (저급)알킬아미노(저급)알킬 에스테르, 약학적 허용(저급) 알킬 아미노(저급)에스테르 산부가염으로부터 선택된 카르복시인 화합물의 카르복시 유도체이며; n은 0, 1, 2 또는 3인데, n이 2 또는 3인 경우 R 치환체중 하나는 카르복시이며, n이 3 또는 3인 경우 모든 치환체는 6개이하의 탄소원자를 함유함을 조건으로 하며; Z는 탄소-탄소 결합, 1 내지 8개의 탄소원자의 2가 알킬 및 2 내지 8개의 탄소원자의 2가의 알킬렌인데, 알킬 또는 알킬렌인 경우, Z는 메틸 또는 페닐에 의해 임의적으로 치환되며 에테르, 티오에테르 또는 페닐렌 결합을 함유하며; A는 카르복시, 테트라졸릴 및 N-메틸테트라졸릴로부터 선택되는데, Z가 탄소-탄소 결합인 경우 A는 카르복시이다.
  2. 제1항에 있어서, 각 R이 수소인 것을 특징으로 하는 화합물.
  3. 제1항에 있어서, 5-(3,5-디-t-부틸-4-히드록시-N-페닐아닐리노)-5-옥소 펜타논산, 4-(3,5-디-t-부틸-4-히드록시)-N-페닐아닐리노)-4-옥소부타논 산, N-(3,5-디-t-부틸-4-히드록시페닐)-N-페닐-2-카르복시페닐아세트아미드, N-(3-카르복시페닐)-N-(3,5-디-t-부틸-4-히드록시페닐)석시남 산, 4-[N-(3,5-디-t-부틸-4-히드록시페닐)-N-페닐카르바모일]-3-메틸 부티르사너 및 N-(3,5-디-t-부틸-4-히드록시페닐)-N-페닐말레안산으로부터 선택된 화합물.
  4. 포유 동물에서 항알레르기성 응답을 얻기 위한 유효양의 상기 제1항의 화합물 및 약학적 허용 부형제로 구성된 항알레르기성 약학적 조성물.
  5. 기관지 협착을 억제하기 위한 유효량의 상기 제1항의 화합물을 포유 동물에 투여하는 것을 특징으로 하는 포유 동물에서 항알레르기 응답에 의해 기관지 협착을 억제하는 방법.
  6. 제5항에 있어서, 상기 화합물은 인할레이숀에 의해 투여되는 것을 특징으로 하는 방법.
  7. 제5항에 있어서, 상기 화합물은 경구 투여 방식에 의해 투여되는 것을 특징으로 하는 방법.
  8. 류코트리엔 합성을 억제하기 위한 유효양의 상기 제1항의 화합물을 포유동물에 투여하는 것으로 구성되는 포유동물에서 류코트리엔 합성을 억제하는 방법.
  9. 리폭시게나아제 활성을 억제하기 위한 유효양의 상기 제1항의 화합물을 상기 포유동물에 투여하는 것으로 구성되는 포유 동물의 리폭시게나아제 활성을 억제하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005889A 1985-07-22 1986-07-21 치환된 디-t-부틸페놀 및 이것을 함유한 약학적 조성물 KR910002371B1 (ko)

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Application Number Priority Date Filing Date Title
US75745485A 1985-07-22 1985-07-22
US757454 1985-07-22
US757.454 1985-07-22

Publications (2)

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KR870001231A true KR870001231A (ko) 1987-03-12
KR910002371B1 KR910002371B1 (ko) 1991-04-20

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EP (1) EP0211549B1 (ko)
JP (1) JPH0717588B2 (ko)
KR (1) KR910002371B1 (ko)
AU (2) AU602126B2 (ko)
CA (1) CA1296341C (ko)
DE (1) DE3676586D1 (ko)
DK (1) DK170592B1 (ko)
ES (1) ES2000369A6 (ko)
IL (1) IL79377A (ko)
NO (1) NO172386C (ko)
NZ (1) NZ216855A (ko)
ZA (1) ZA865091B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA865090B (en) 1985-07-22 1988-02-24 Riker Laboratories Inc Substituted di-t-butylphenols
JPS6229557A (ja) * 1985-07-29 1987-02-07 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
JPH0610174B2 (ja) * 1986-09-29 1994-02-09 株式会社大塚製薬工場 アミノフエノ−ル誘導体
IL85896A (en) * 1987-04-06 1993-01-14 Riker Laboratories Inc Substituted di-tert.- butylphenols and pharmaceutical compositions containing them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044144A (en) * 1973-03-23 1977-08-23 American Home Products Corporation 1H-tetrazole-5-carboxamides
DE2546996C2 (de) * 1975-10-21 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Phenoxyalkylcarbonsäure-Derivate, Verfahren zur Herstellung derselben sowie Arzneimittel, die diese Verbindungen als Wirkstoff enthalten
US4172151A (en) * 1977-05-16 1979-10-23 Riker Laboratories, Inc. Anti-inflammatory method
NL7810634A (nl) * 1977-10-28 1979-05-02 May & Baker Ltd Tetrazool-derivaten.
JP2677618B2 (ja) * 1988-07-11 1997-11-17 日本ペイント株式会社 水性塗料組成物

Also Published As

Publication number Publication date
IL79377A (en) 1990-03-19
DK344886A (da) 1987-01-23
ZA865091B (en) 1988-02-24
EP0211549B1 (en) 1990-12-27
NO172386C (no) 1993-07-14
CA1296341C (en) 1992-02-25
DK170592B1 (da) 1995-11-06
EP0211549A3 (en) 1987-08-19
IL79377A0 (en) 1986-10-31
ES2000369A6 (es) 1988-02-16
AU602126B2 (en) 1990-10-04
EP0211549A2 (en) 1987-02-25
AU5870690A (en) 1991-01-24
NO862925L (no) 1987-01-23
AU638260B2 (en) 1993-06-24
DE3676586D1 (de) 1991-02-07
NO862925D0 (no) 1986-07-21
KR910002371B1 (ko) 1991-04-20
JPS6270351A (ja) 1987-03-31
JPH0717588B2 (ja) 1995-03-01
NZ216855A (en) 1991-03-26
DK344886D0 (da) 1986-07-21
AU6008686A (en) 1987-01-29
NO172386B (no) 1993-04-05

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