KR890008087A - 알콕시 또는 벤질옥시기, 또는 벤질티오기로 치환된 디-t-부틸페놀 - Google Patents

알콕시 또는 벤질옥시기, 또는 벤질티오기로 치환된 디-t-부틸페놀 Download PDF

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Publication number
KR890008087A
KR890008087A KR1019880014935A KR880014935A KR890008087A KR 890008087 A KR890008087 A KR 890008087A KR 1019880014935 A KR1019880014935 A KR 1019880014935A KR 880014935 A KR880014935 A KR 880014935A KR 890008087 A KR890008087 A KR 890008087A
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South Korea
Prior art keywords
butyl
compound
tetrazole
phenyl
pharmaceutically acceptable
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KR1019880014935A
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English (en)
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알란 퍼스타드 마크
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더블류.조오지 메레딕스
라이커 레보레토이즈 인코오포레이티드
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Publication of KR890008087A publication Critical patent/KR890008087A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

알콕시 또는 벤질옥시기, 혹은 벤질티오기로 치환된 디-t-부티페놀
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)의 화합물 또는 이들 화합물의 유도체 :
    상기식에서, A는 산소 또는 황원자 : B는 C3-8의 직쇄 알킬렌기 또는
    (여기서 R은 수소, 할로겐, 저급 알킬 또는 저급알콕시) : D는 카르복시 또는 테트라졸일인데 : 조건부로, A가 황일때는 B는이고, A가 산소일때는 D는 테트라졸일어어야만하며 : 상기 화합물의 유도체에서 : D는 저급알킬 에스테르, (저급)알킬아미노(저급)알킬에스테르, 약학적 허용 저급(알킬)아미노(저급)알킬 에스테르산부가염, 또는 약학적 허용 카르복실산염으로 구성된 그룹으로부터 선택되는 카르복시이거나 : 혹은 D는 테트라졸일 성분중에 약학적 허용 알칼리 금속 또는 알킬리토류염으로부터 선택되는 테트라졸일이다
  2. 제 1 항에 있어서, A가 산소원자인 화합물
  3. 제 2 항에 있어서, B가 상기 알킬렌기인 화합물
  4. 제 2 항에 있어서, B가 상기기인 화합물
  5. 제 1 항에 있어서, 5-[4-(3,5-디-t-부틸-4-히드록시페녹시메틸)-페닐]테트라졸, 5-[6-(3,5-디-t-부틸-4-히드록시페녹시)-헥실]테트라졸, 5-[2-(3,5-디-t-부틸-4-히드록시페녹시메틸)-페닐]테트라졸, 5-[3-(3,5-디-t-부틸-4-히드록시페녹시)-프로필]테트라졸,5-[3-(3,5-디-t-부틸-4-히드록시-페녹시메틸)-부틸]테트라졸,5-[5-(3,5-디-t-부틸-4-히드록시)-펜틸]테드라졸, 5-[4-(3,5-디-t-부틸-4-히드록시-페녹시)-부틸]테트라졸, 5-[4-(3,5-디-t-부틸-4-히드록시페닐티오)메틸-페닐]테트라졸,및 5-[3-(3,5-디-t-부틸-4-히드록시페녹시메틸)-페닐]테트라졸로 구성된 그룹으로부터 선택되는 화합물
  6. 제 1 항에 있어서, A가 황원자인 화합물
  7. 알레르기 질환을 억제하는데 유효한 양으로 존재하는 제 1 항의 화합물, 및 약학적 허용 부형제로 구성된 항알레르기 약학적 조성물
  8. 기관지 수축을 억제하는데 충분한 양으로 제 1 항의 화합물을 표유동물에 투여하는 것을 특징으로 하는 포유동물의 기관지 수축을 억제하는 방법
  9. 루케오트리엔 생합성을 억제하는데 유효한 양으로 제 1 항의 화합물을 포유동물에 투여하는 것을 특징으로 하는 포유동물의 루케오트리엔 생합성을 억제하는 방법
  10. 하기 일반식 (IV)의 화합물
    상기식에서, A는 산소 또는 황원자 : B는 C3-8의 직쇄 알킬렌기 또는(여기서, R은 수소, 할로겐, 저급알킬 또는 저급알콕시)인데 조건부로, A가 황일 때 B는이어야 한다
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014935A 1987-11-13 1988-11-12 알콕시 또는 벤질옥시기, 또는 벤질티오기로 치환된 디-t-부틸페놀 KR890008087A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12046887A 1987-11-13 1987-11-13
US120,468 1987-11-13

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KR890008087A true KR890008087A (ko) 1989-07-08

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EP (1) EP0317165B1 (ko)
JP (1) JP2520161B2 (ko)
KR (1) KR890008087A (ko)
AU (1) AU618764B2 (ko)
CA (1) CA1325431C (ko)
DE (1) DE3887463T2 (ko)
DK (1) DK626888A (ko)
ES (1) ES2061687T3 (ko)
IL (1) IL88110A (ko)
NO (1) NO170013C (ko)
NZ (1) NZ226621A (ko)
ZA (1) ZA887991B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3903989A1 (de) * 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
AU750041B2 (en) 1997-05-14 2002-07-11 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
EP1695959A1 (en) * 1997-05-14 2006-08-30 Atherogenics, Inc. Compouds and methods for the inhibition of the expression of VCAM-1
AU2006202461B2 (en) * 1997-05-14 2009-12-03 Atherogenics, Inc. Compositions and methods for the inhibition of the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
CN101686676A (zh) 2007-03-26 2010-03-31 沙路特里亚制药有限责任公司 用于治疗糖尿病的方法和普罗布考衍生物的组合物
WO2020019994A1 (zh) * 2018-07-25 2020-01-30 上海挚盟医药科技有限公司 一类具有神经保护作用的化合物及其制备方法和用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079855A1 (de) * 1981-11-12 1983-05-25 Ciba-Geigy Ag Alkylierte Hydroxyphenylthioalkansäureester
EP0218782B1 (en) * 1985-05-20 1990-05-16 G.D. Searle & Co. Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds
ZA865090B (en) * 1985-07-22 1988-02-24 Riker Laboratories Inc Substituted di-t-butylphenols
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase
ZA882251B (en) * 1987-04-06 1989-11-29 Riker Laboratories Inc Substituted di-t-butylphenols
US4973731A (en) * 1987-04-23 1990-11-27 Riker Laboratories, Inc. Di-t-butylphenyl alkyl and benzyl ether nitriles

Also Published As

Publication number Publication date
IL88110A (en) 1993-01-14
CA1325431C (en) 1993-12-21
DE3887463D1 (de) 1994-03-10
ZA887991B (en) 1990-06-27
JPH02160A (ja) 1990-01-05
DK626888A (da) 1989-06-19
DE3887463T2 (de) 1994-08-25
IL88110A0 (en) 1989-06-30
JP2520161B2 (ja) 1996-07-31
AU618764B2 (en) 1992-01-09
NO170013B (no) 1992-05-25
DK626888D0 (da) 1988-11-10
EP0317165B1 (en) 1994-01-26
EP0317165A1 (en) 1989-05-24
ES2061687T3 (es) 1994-12-16
AU2466888A (en) 1989-05-18
NZ226621A (en) 1991-12-23
NO884770L (no) 1989-05-16
NO884770D0 (no) 1988-10-26
NO170013C (no) 1992-09-02

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