KR880007411A - 레티논산과 같은 작용을 갖는 에티닐헤테로 방향족-산류 - Google Patents

레티논산과 같은 작용을 갖는 에티닐헤테로 방향족-산류 Download PDF

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KR880007411A
KR880007411A KR870014758A KR870014758A KR880007411A KR 880007411 A KR880007411 A KR 880007411A KR 870014758 A KR870014758 A KR 870014758A KR 870014758 A KR870014758 A KR 870014758A KR 880007411 A KR880007411 A KR 880007411A
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찬드라라트나 로산타 에이. 에스
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제임스 엠. 케나지
알러겐, 인크.
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Abstract

내용 없음.

Description

레티논산과 같은 작용을 갖는 에티닐헤테로 방향족-산류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

1) 일반식
의 화합물이나 약제학적 허용염. 이식에서, A는 피리딜, 푸릴, 티에닐, 피리다지닐, 피리미디닐이나 피라지닐이고; n은 0-5이며; B는 H, -COOH또는 그것의 에스테르류, 아미드류화 약제학적 허용염, -CHO 및 그것의 아세탈 유도체들, 또는 -COR1및 그것의 케탈유도체들로서 R1이 -(CH2)nCH3이며, 여기서 n은 위에서 정의된 바와 같은 것이다.
A가 피리딜인 제1항의 화합물.
B가 -COOH 및 그것의 저급알킬에스테르, -CHO 또는 -CH2OH인 제2항의 화합물이나 약제학상 허용염.
제3항에 있어서, 에틸 6-[4-2,6,6-트리메틸사이클로헥스-1-에닐)-부트-3-엔-1-이닐]니코틴산염이나, 6-[4-(2,6,6-트리메틸사이클로헥스-1-에닐)-부트-3-엔-1-엔-1-아닐린] 니코산이며 n이 0인 화합물이나 이것의 약제학적 허용염.
A가 푸릴인 제1항의 화합물.
B가 -COOH 및 그것의 에스텔, -CHO 또는 -CH2OR인 제5항의 화합물이나 약제학상 허용염.
제6항에 있어서, 에틸 5-[4-(2,6,6-트리메틸사이클로헥스-1-에닐)-부트-3-엔-1-이닐]푸라노에이트, 또는 5-[4-(2,6,6 트리메틸-사이클로헥스 -1-에닐)-부트-3-엔-1-이닐]-푸라논산으로 n이 0인 화합물이나 이의 약제학상 허용염.
A가 티에닐인 제1항의 화합물.
B가 -COOH과 그것의 에스테르, -CHO나 -CH2OR인 제8항의 화합물이나 약제학상 허용염.
제9항에 있어서, 에틸 5-[4-(2,6,6-트리메틸사이클로헥스-1-에닐)-부트-3-엔-1-이닐]-티오펜-2-카복실레이트, 또는 5-[4-(2,6,6- 트리메틸사이클로헥스-1-에닐)-부트-3-엔-1-이닐]-티오펜-2-카복실산으로 n이 0인 화합물.
A가 피리다지닐, 피리미디닐 또는 피라지닐인 제1항의 화합물.
다음 일반식 화합물이나 그것의 제약적으로 허용되는 염의 단독이나 그 제약적으로 허용되는 부형제와의 혼합물을 치료학적으로 효과적인 양으로 이것을 필요로 하는 포유동물에 투여하는 것으로 구성되는 포유동물에서 건선을 치료하는 방법.
A는 피리딜, 푸릴, 티에닐, 피리다지닐, 피리미디닐이거나 피라지닐이며; n은 0-5이고; B는 H, -COOH및 그 에스테르, 아미드 및 그 제약적 허용염, -CHO 및 그 아세탈유도체, 또는 -COR1및 그것의 케탈유도체로서 R1이 -(CH2)nCH3(여기에서 n은 위에서 정의한 바와 같음)인 것이다.
약제학적으로 허영되는 부형제와 다음 일반식의 화합물이나 제약적으로 허영되는 염으로 구성되는 약제학적 조성물.
A는 피리딜, 푸릴, 티에닐, 피리다지닐, 피리미디닐이거나 피라지닐이며; n은 0-5이고; B는 H, -COOH및 그 에스테르, 아미드 및 그 제약적 허용염, -CHO 및 그 아세탈유도체, 또는 -COR1및 그것의 케탈유도체로서 R1이 -(CH2)nCH3(여기에서 n은 위에서 정의한 바와 같음)인 것이다.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870014758A 1986-12-24 1987-12-23 레틴산 유사 활성을 갖는 에티닐헤테로방향족 산 및 이를 함유한 약제학적 조성물 KR960000074B1 (ko)

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NO875422L (no) 1988-06-27
FI875681A0 (fi) 1987-12-22
CN87107535A (zh) 1988-08-31
EP0272921B1 (en) 1991-04-24
AU8292587A (en) 1988-06-30
NO175205C (no) 1994-09-14
HU198295B (en) 1989-09-28
DE3769618D1 (de) 1991-05-29
DK682087D0 (da) 1987-12-22
GR3002101T3 (en) 1992-12-30
IE61902B1 (en) 1994-11-30
PT86442A (en) 1988-01-01
NZ222968A (en) 1990-05-28
EG19587A (en) 1995-06-29
HUT46307A (en) 1988-10-28
IE873493L (en) 1988-06-24
EP0272921A1 (en) 1988-06-29
CA1326853C (en) 1994-02-08
ZA879595B (en) 1989-09-27
FI875681A (fi) 1988-06-25
CN1024006C (zh) 1994-03-16
ES2036591T3 (es) 1993-06-01
DK682087A (da) 1988-06-25
MY103040A (en) 1993-04-30
JPS63190878A (ja) 1988-08-08
PH23861A (en) 1989-11-23
AU599444B2 (en) 1990-07-19
PT86442B (pt) 1990-11-20
DK167011B1 (da) 1993-08-16
NO875422D0 (no) 1987-12-23
KR960000074B1 (ko) 1996-01-03
IL84878A0 (en) 1988-06-30
IL84878A (en) 1992-06-21
FI90766B (fi) 1993-12-15
NO175205B (ko) 1994-06-06
JP2693957B2 (ja) 1997-12-24
FI90766C (fi) 1994-03-25
ATE62899T1 (de) 1991-05-15

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