KR870001164A - N-아르알킬 피페리딘메탈올 유도체의 제조방법 - Google Patents

N-아르알킬 피페리딘메탈올 유도체의 제조방법 Download PDF

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KR870001164A
KR870001164A KR1019860005319A KR860005319A KR870001164A KR 870001164 A KR870001164 A KR 870001164A KR 1019860005319 A KR1019860005319 A KR 1019860005319A KR 860005319 A KR860005319 A KR 860005319A KR 870001164 A KR870001164 A KR 870001164A
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phenyl ring
formula
ring bonded
substituents
methanol
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KR1019860005319A
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KR900001184B1 (ko
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에이. 칼 알버트
엘. 위이치 노버트
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메렐 다우 파마슈티칼스 인코포레이티드
게리 디. 스트리트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

N-아르알킬 피페리딘메탈올 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식 (IIa),(IIb),(IIc) 또는 (IId)의 화합물을 화학적으로 환원시키거나, 하기 일반식(V)의 화합물을 하기 일반식(III)의 반응성 유도체로 알킬화시키거나, 하기 일반식(XI)의 그리그나드 시약을 하기 일반식(VI)의 알데하이드와 반응시킨 다음 반응생성물을 가수분해시킴을 특징으로 하여, 하기 일반식(I)의 화합물, 그의 광학적 이성체 및 그의 약제학적으로 허용되는 염을 제조하는 방법.
    상기 식에서, 각 R 및 R1은 독립적으로 수소, C1-6알킬, 할로겐, 트리플루오메틸, 하이드록시, C1-6알콕시, 또는 아미노이고, n은 2,3 또는 4이며, X는 반응성 잔기, 바람직하게는 할라이드, 토실레이트, 메실레이트 또는 그의 작용성 등가물이다.
  2. 제1항에 있어서, n이 2인 방법
  3. 제1항에 있어서, n이 3인 방법.
  4. 제1항에 있어서, 알킬에 결합된 페닐환상의 치환체 R 및 R1이 수소인 방법.
  5. 제4항에 있어서, 메탄올에 결합된 페닐환상의 치환체 R 및 R1이 수소인 방법.
  6. 제1항에 있어서, 메탄올에 결합된 페닐환상의 치환체 R 및 R1이 메톡시이고, 알킬에 결합된 페닐환상의 치환체 R 및 R1이 수소인 방법.
  7. 제1항에 있어서, 메탄올에 결합된 페닐환상의 치환체 R이 메톡시이고, 메탄올에 결합된 페닐환상의 치환체 R1, 알킬에 결합된 페닐환상의 치환체 R 및 R1이 각각 수소인 방법.
  8. 제1항에 있어서, 메탄올에 결합된 페닐환상의 치환체 R 및 R′이 할로겐이고, 알킬에 결합된 페닐환상의 치환체 R 및 R1이 수소인 방법.
  9. 제1항에 있어서, 메탄올에 결합된 페닐환상의 치환체 R이 메틸이고, 메탄올에 결합된 페닐환상의 치환체 R1, 알킬에 결합된 페닐환상의 치환체 R 및 R1이 각각 수소인 방법.
  10. 하기 구조식 (VIIIa), (VIIIb), (VIIIc) 또는 (VIIId)의 화합물을 화학적으로 환원시키거나, 하기 구조식(IX)의 화합물을 하기 일반식(X)의 알킬화제로 알킬화시키거나, 하기 구조식(XIII)의 그리그나드 시약을 하기 구조식(XII)의 알데하이드와 반응시킨 다음 반응 생성물을 가수분해시킴을 특징으로 하여, 하기 구조식(VII)의 화합물을 제조하는 방법.
    상기 식에서, X-치환체는 할라이드, 토실레이트, 메실레이트 또는 그의 작용성 등가물이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005319A 1985-07-02 1986-07-01 N-아르알킬 피페리딘메탄올 유도체의 제조방법 KR900001184B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75141985A 1985-07-02 1985-07-02
US751,419 1985-07-02
US751419 1985-07-02

Publications (2)

Publication Number Publication Date
KR870001164A true KR870001164A (ko) 1987-03-11
KR900001184B1 KR900001184B1 (ko) 1990-02-27

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KR1019860005319A KR900001184B1 (ko) 1985-07-02 1986-07-01 N-아르알킬 피페리딘메탄올 유도체의 제조방법

Country Status (21)

Country Link
EP (1) EP0208235B1 (ko)
JP (1) JPH0655720B2 (ko)
KR (1) KR900001184B1 (ko)
CN (1) CN1023895C (ko)
AR (2) AR241904A1 (ko)
AT (1) ATE49403T1 (ko)
AU (1) AU590582B2 (ko)
CA (1) CA1280421C (ko)
DE (1) DE3668167D1 (ko)
DK (1) DK174153B1 (ko)
ES (1) ES2000299A6 (ko)
FI (1) FI84474C (ko)
GR (1) GR861699B (ko)
HU (1) HU196058B (ko)
IE (1) IE58460B1 (ko)
IL (1) IL79266A (ko)
NO (1) NO167384C (ko)
NZ (1) NZ216689A (ko)
PH (1) PH22141A (ko)
PT (1) PT82890B (ko)
ZA (1) ZA864772B (ko)

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FI84474B (fi) 1991-08-30
PH22141A (en) 1988-06-01
IL79266A (en) 1990-04-29
DK312386D0 (da) 1986-07-01
NO862661L (no) 1987-01-05
FI84474C (fi) 1991-12-10
ZA864772B (en) 1987-02-25
IE58460B1 (en) 1993-09-22
IE861771L (en) 1987-01-02
FI862801A0 (fi) 1986-07-01
DE3668167D1 (de) 1990-02-15
CN1023895C (zh) 1994-03-02
NZ216689A (en) 1989-07-27
NO167384C (no) 1991-10-30
CN86104408A (zh) 1987-05-20
DK312386A (da) 1987-01-03
HUT41387A (en) 1987-04-28
PT82890B (pt) 1988-05-27
FI862801A (fi) 1987-01-03
AU590582B2 (en) 1989-11-09
CA1280421C (en) 1991-02-19
KR900001184B1 (ko) 1990-02-27
EP0208235A1 (en) 1987-01-14
HU196058B (en) 1988-09-28
GR861699B (en) 1986-10-31
ES2000299A6 (es) 1988-02-16
NO862661D0 (no) 1986-07-01
ATE49403T1 (de) 1990-01-15
JPH0655720B2 (ja) 1994-07-27
AR241904A1 (es) 1993-01-29
DK174153B1 (da) 2002-07-29
JPS625955A (ja) 1987-01-12
PT82890A (en) 1986-08-01
EP0208235B1 (en) 1990-01-10
AU5931886A (en) 1987-01-08
AR242184A1 (es) 1993-03-31
NO167384B (no) 1991-07-22

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