KR880005075A - 아제티디논 유도체 - Google Patents

아제티디논 유도체 Download PDF

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Publication number
KR880005075A
KR880005075A KR870011493A KR870011493A KR880005075A KR 880005075 A KR880005075 A KR 880005075A KR 870011493 A KR870011493 A KR 870011493A KR 870011493 A KR870011493 A KR 870011493A KR 880005075 A KR880005075 A KR 880005075A
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South Korea
Prior art keywords
group
lower alkyl
alkyl group
structural formula
hydrogen atom
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KR870011493A
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English (en)
Inventor
유따까 가와시마
마사까즈 사또
유이찌 하따다
후미꼬 하자또
요시모또 나가시마
가오루 소따
Original Assignee
우에 하라 쇼지
다이쇼 세이야꾸 가부시끼가이샤
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Application filed by 우에 하라 쇼지, 다이쇼 세이야꾸 가부시끼가이샤 filed Critical 우에 하라 쇼지
Publication of KR880005075A publication Critical patent/KR880005075A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/10—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아제티디논 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식으로 표시되는 2-아제티디논 유도체
    상기식 중, X 는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 히드록실기 또는 시아노기이고, ℓ은 1또는 2이고, R1은 저급 알킬기, 시클로알킬기, 1-나프틸메틸기, 1-페네틸기, 1-카르복시-2-페네틸기, 구조식
    (식중, Y및 Y1는 동일하거나 또는 상이한 것으로서, 각각 수소 원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 디메틸아미노기, 카르복실기, 디클로로아세틸기 또는 트리플루오로메틸기이거나 또는 Y및 Y1는 함께 메틸렌 디옥시기를 형성하고, m은 0또는 1임)의 기 또는 구조식
    (식중, R3은 저급 알킬기임)의 기이며, R2는 저급 알킬기, 저급 알콕시기, 아미노기, 아다만틸기, 저급 알콕시카르보닐메틸기, 또는 구조식
    (식중, Z는 수소 원자, 할로겐원자, 저급알킬기, 저급알킬기, 저급 알콕시기, 페닐기 또는 니트로기이고, n은 1또는 2임)의 기이다.
  2. 하기 일반식으로 표시되는 2-아제티디논 유도체를 함유하는 혈소판 응집 억제제.
    상기식중, X는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 히드록실기 또는 시아노기이고, ℓ은 1또는 2이고, R1은 저급 알킬기, 시클로알킬기, 1-나프틸메틸기, 1-페네틸기, 1-카르복시-2-페네틸기, 구조식
    (식중, Y및 Y1는 동일하거나 또는 상이한 것으로서, 각각 수소 원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 디메틸아미노기, 카르복실기, 디클로로아세틸기 또는 트리플루오로메틸기이거나 또는 Y및 Y1는 함께 메틸렌 디옥시기를 형성하고, m은 0또는 1임)의 기 또는 구조식
    (상기, R3은 저급 알킬기임)의 기이며, R2는 저급 알킬기, 저급 알콕시기, 아미노기, 아다만틸기, 저급 알콕시카르보닐메틸기, 구조식
    (식중, Z는 수소원자, 할로겐원자, 저급 알킬기, 저급 알콕시기, 페닐기 또는 니트로기이고, n은 1또는 2임)의기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870011493A 1986-10-17 1987-10-16 아제티디논 유도체 KR880005075A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP246638 1986-10-17
JP24663886 1986-10-17

Publications (1)

Publication Number Publication Date
KR880005075A true KR880005075A (ko) 1988-06-27

Family

ID=17151382

Family Applications (1)

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KR870011493A KR880005075A (ko) 1986-10-17 1987-10-16 아제티디논 유도체

Country Status (4)

Country Link
US (1) US4803266A (ko)
EP (1) EP0264231A1 (ko)
JP (1) JPS63225353A (ko)
KR (1) KR880005075A (ko)

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US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof
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US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) * 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
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US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
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US7417039B2 (en) * 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
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US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
MXPA04002573A (es) * 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
MXPA04002572A (es) * 2001-09-21 2004-05-31 Schering Corp Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol.
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1562582A1 (en) * 2002-11-06 2005-08-17 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
JP4589919B2 (ja) * 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
MXPA05009502A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
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US4803266A (en) 1989-02-07
EP0264231A1 (en) 1988-04-20
JPS63225353A (ja) 1988-09-20

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