KR880005075A - 아제티디논 유도체 - Google Patents
아제티디논 유도체 Download PDFInfo
- Publication number
- KR880005075A KR880005075A KR870011493A KR870011493A KR880005075A KR 880005075 A KR880005075 A KR 880005075A KR 870011493 A KR870011493 A KR 870011493A KR 870011493 A KR870011493 A KR 870011493A KR 880005075 A KR880005075 A KR 880005075A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- lower alkyl
- alkyl group
- structural formula
- hydrogen atom
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/10—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 하기 일반식으로 표시되는 2-아제티디논 유도체상기식 중, X 는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 히드록실기 또는 시아노기이고, ℓ은 1또는 2이고, R1은 저급 알킬기, 시클로알킬기, 1-나프틸메틸기, 1-페네틸기, 1-카르복시-2-페네틸기, 구조식(식중, Y및 Y1는 동일하거나 또는 상이한 것으로서, 각각 수소 원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 디메틸아미노기, 카르복실기, 디클로로아세틸기 또는 트리플루오로메틸기이거나 또는 Y및 Y1는 함께 메틸렌 디옥시기를 형성하고, m은 0또는 1임)의 기 또는 구조식(식중, R3은 저급 알킬기임)의 기이며, R2는 저급 알킬기, 저급 알콕시기, 아미노기, 아다만틸기, 저급 알콕시카르보닐메틸기, 또는 구조식(식중, Z는 수소 원자, 할로겐원자, 저급알킬기, 저급알킬기, 저급 알콕시기, 페닐기 또는 니트로기이고, n은 1또는 2임)의 기이다.
- 하기 일반식으로 표시되는 2-아제티디논 유도체를 함유하는 혈소판 응집 억제제.상기식중, X는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 히드록실기 또는 시아노기이고, ℓ은 1또는 2이고, R1은 저급 알킬기, 시클로알킬기, 1-나프틸메틸기, 1-페네틸기, 1-카르복시-2-페네틸기, 구조식(식중, Y및 Y1는 동일하거나 또는 상이한 것으로서, 각각 수소 원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 디메틸아미노기, 카르복실기, 디클로로아세틸기 또는 트리플루오로메틸기이거나 또는 Y및 Y1는 함께 메틸렌 디옥시기를 형성하고, m은 0또는 1임)의 기 또는 구조식(상기, R3은 저급 알킬기임)의 기이며, R2는 저급 알킬기, 저급 알콕시기, 아미노기, 아다만틸기, 저급 알콕시카르보닐메틸기, 구조식(식중, Z는 수소원자, 할로겐원자, 저급 알킬기, 저급 알콕시기, 페닐기 또는 니트로기이고, n은 1또는 2임)의기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP246638 | 1986-10-17 | ||
JP24663886 | 1986-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880005075A true KR880005075A (ko) | 1988-06-27 |
Family
ID=17151382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR870011493A KR880005075A (ko) | 1986-10-17 | 1987-10-16 | 아제티디논 유도체 |
Country Status (4)
Country | Link |
---|---|
US (1) | US4803266A (ko) |
EP (1) | EP0264231A1 (ko) |
JP (1) | JPS63225353A (ko) |
KR (1) | KR880005075A (ko) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952689A (en) * | 1988-10-20 | 1990-08-28 | Taisho Pharmaceutical Co., Ltd. | 3-(substituted propylidene)-2-azetidinone derivates for blood platelet aggregation |
FR2640621B1 (fr) * | 1988-12-19 | 1992-10-30 | Centre Nat Rech Scient | N-aryl-azetidinones, leur procede de preparation et leur utilisation comme inhibiteurs des elastases |
US5175283A (en) * | 1990-06-04 | 1992-12-29 | Bristol-Myers Squibb Company | Azetidin-2-one derivatives as serine protease inhibitors |
US5110812A (en) * | 1990-06-04 | 1992-05-05 | Bristol-Myers Squibb Co. | Azetidin-2-one derivatives as serine protease inhibitors |
US5037819A (en) * | 1990-06-04 | 1991-08-06 | Bristol-Myers Squibb Company | Azetidin-2-one derivatives as serine protease inhibitors |
US5250677A (en) * | 1990-06-04 | 1993-10-05 | Bristol-Myers Squibb Company | Azetidin-2-one derivatives as serine protease inhibitors |
HUT67341A (en) * | 1991-07-23 | 1995-03-28 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof |
US5688785A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
US5688787A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
LT3369B (en) | 1992-12-29 | 1995-08-25 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US6593078B1 (en) * | 1999-04-16 | 2003-07-15 | Schering Corporation | Use of azetidinone compounds |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
DK1413331T3 (da) * | 2001-01-26 | 2007-12-10 | Schering Corp | Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivatoren fenofibrat og sterolabsorptionsinhibitoren ezetimib til vaskulære indikationer |
US20030053981A1 (en) * | 2001-01-26 | 2003-03-20 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
KR20080077033A (ko) * | 2001-01-26 | 2008-08-20 | 쉐링 코포레이션 | 혈관 질환을 치료하기 위한 스테롤 흡수 억제제와 심혈관제제의 조합물 |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
AU2002240050A1 (en) * | 2001-01-26 | 2002-08-06 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
ATE381347T1 (de) * | 2001-01-26 | 2008-01-15 | Schering Corp | Kombinationen von ezetimibe und aspirin zur behandlung von kardiovaskulären erkrankungen |
US7417039B2 (en) * | 2001-01-26 | 2008-08-26 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
EE05453B1 (et) | 2001-03-28 | 2011-08-15 | Schering Corporation | Protsess asetidinoonvahehendite valmistamiseks |
WO2002096415A2 (en) * | 2001-05-25 | 2002-12-05 | Schering Corporation | Use of azetidinone substituted derivatives in the treatment of alzheimer's disease |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
MXPA04002573A (es) * | 2001-09-21 | 2004-06-18 | Schering Corp | Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol. |
MXPA04002572A (es) * | 2001-09-21 | 2004-05-31 | Schering Corp | Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol. |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
EP1562582A1 (en) * | 2002-11-06 | 2005-08-17 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
JP4589919B2 (ja) * | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
MXPA05009502A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
JP2007510659A (ja) * | 2003-11-05 | 2007-04-26 | シェーリング コーポレイション | 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置 |
CN103570600B (zh) * | 2012-07-20 | 2017-12-05 | 中国科学院上海有机化学研究所 | 一种手性α‑亚甲基β‑内酰胺类化合物及其制备方法和应用 |
WO2017167183A1 (zh) * | 2016-03-29 | 2017-10-05 | 复旦大学 | 二芳基-β-内酰胺类化合物及其制备方法和在制药中的用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK425384A (da) * | 1983-09-28 | 1985-03-29 | Nippon Zoki Pharmaceutical Co | Acylindol-derivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater som indeholder dem |
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1987
- 1987-10-05 US US07/104,152 patent/US4803266A/en not_active Expired - Fee Related
- 1987-10-09 JP JP62255521A patent/JPS63225353A/ja active Pending
- 1987-10-09 EP EP87308942A patent/EP0264231A1/en not_active Withdrawn
- 1987-10-16 KR KR870011493A patent/KR880005075A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US4803266A (en) | 1989-02-07 |
EP0264231A1 (en) | 1988-04-20 |
JPS63225353A (ja) | 1988-09-20 |
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Legal Events
Date | Code | Title | Description |
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WITB | Written withdrawal of application |