ES2000299A6 - Procedimiento para la preparaciom de nuevos derivados de n-aralquil-piperinmetanol - Google Patents
Procedimiento para la preparaciom de nuevos derivados de n-aralquil-piperinmetanolInfo
- Publication number
- ES2000299A6 ES2000299A6 ES8600071A ES8600071A ES2000299A6 ES 2000299 A6 ES2000299 A6 ES 2000299A6 ES 8600071 A ES8600071 A ES 8600071A ES 8600071 A ES8600071 A ES 8600071A ES 2000299 A6 ES2000299 A6 ES 2000299A6
- Authority
- ES
- Spain
- Prior art keywords
- aralkyl
- derivatives
- piperidinemethanol derivatives
- relates
- aralkyl piperidinemethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
ESTA INVENCION SE REFIERE A UNA NUEVA CLASE DE COMPUESTOS CON IMPORTANTES PROPIEDADES BIOQUIMICAS Y FARMACOLOGICAS. MAS ESPECIALMENTE, ESTA INVENCION SE REFIERE A DERIVADOS DE N-ARALQUIL-PIPERIFINMETANOL QUE SON POTENTES Y SELECTIVOS INHIBIDORES DE LA UNION DE LA SEROTONINA AL SITIO RECEPTOR 5HT2 Y A PROCEDIMIENTOS PARA SU PREPARACION Y USO. LOS COMPUESTOS DE ESTAINVENCION SON PRESENTADOS POR LA FORMULA:SUS ISOMEROS OPTICOSY SUS MEZCLAS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDEN ES 2, 3 O 4 Y CADA GRUPO R Y R1 REPRESENTA INDEPENDIENTEMENTE HIDROGENO, ALQUILO C1-6, HALOGENO, TRIFLUORMETILO, HIDROXI, ALCOXI C1-6 O AMINO. REPRESENTATIVOS DE LOS SUSTITUYENTES RY R1 PARA ALQUILO C1-6 SON METILO, ETILO, PROPILO, ISOPROPILO, N-BUTILO, T-BUTILO, PENTILO, HEXILO, CICLOPROPILO Y CICLOPENTILO, SIENDO PREFERIDOS METILO Y ETILO. ESTAN COMPRENDIDOS TODOS LOS HALOGENOS, SIENDO PREFERIDOS FLUOR Y CLORO. REPRESENTATIVOS DE LOS SUSTITUYENTES ALCOXI C1-6 SON METOXI, ETOXI.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75141985A | 1985-07-02 | 1985-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2000299A6 true ES2000299A6 (es) | 1988-02-16 |
Family
ID=25021900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8600071A Expired ES2000299A6 (es) | 1985-07-02 | 1986-07-01 | Procedimiento para la preparaciom de nuevos derivados de n-aralquil-piperinmetanol |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0208235B1 (es) |
JP (1) | JPH0655720B2 (es) |
KR (1) | KR900001184B1 (es) |
CN (1) | CN1023895C (es) |
AR (2) | AR241904A1 (es) |
AT (1) | ATE49403T1 (es) |
AU (1) | AU590582B2 (es) |
CA (1) | CA1280421C (es) |
DE (1) | DE3668167D1 (es) |
DK (1) | DK174153B1 (es) |
ES (1) | ES2000299A6 (es) |
FI (1) | FI84474C (es) |
GR (1) | GR861699B (es) |
HU (1) | HU196058B (es) |
IE (1) | IE58460B1 (es) |
IL (1) | IL79266A (es) |
NO (1) | NO167384C (es) |
NZ (1) | NZ216689A (es) |
PH (1) | PH22141A (es) |
PT (1) | PT82890B (es) |
ZA (1) | ZA864772B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
ZA888572B (en) * | 1987-11-23 | 1989-08-30 | Merrell Dow Pharma | Treatment of fibromyalgia |
JPH02138214A (ja) * | 1987-12-10 | 1990-05-28 | Merrell Dow Pharmaceut Inc | 不安を治療する方法 |
US5093341A (en) * | 1987-12-17 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine derivatives useful as antithrombolytic agents |
EP0325063B1 (en) * | 1988-01-21 | 1994-03-09 | Merrell Dow Pharmaceuticals Inc. | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia |
ZA891901B (en) * | 1988-03-17 | 1989-11-29 | Merrell Dow Pharma | Method for the treatment of the extrapyramidal side effects associated with neuroleptic therapy |
JP2969359B2 (ja) * | 1989-01-13 | 1999-11-02 | 武田薬品工業株式会社 | 環状アミン化合物 |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
ZA9010081B (en) * | 1989-12-20 | 1991-10-30 | Merrell Dow Pharma | Method for the treatment of glaucoma |
JP2758050B2 (ja) * | 1989-12-27 | 1998-05-25 | 株式会社トクヤマ | 土質安定用薬液およびその注入工法 |
US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
AU652759B2 (en) * | 1990-06-01 | 1994-09-08 | Aventisub Ii Inc. | (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)- 4-piperidinemethanol |
JPH07111050B2 (ja) * | 1990-12-12 | 1995-11-29 | 株式会社親和テクノ | セメントグラウトを用いた地盤注入工法 |
FR2672286B1 (fr) * | 1991-01-31 | 1994-11-18 | Synthelabo | Derives de 1-(4-chlorophenyl)-2-[4-(phenylmethyl)piperidin-1-yl]ethanol, leur preparation et leur application en therapeutique. |
ZA929008B (en) * | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
AU4659793A (en) * | 1992-06-30 | 1994-01-24 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Anorectic epinephrine derivatives |
FR2696741B1 (fr) * | 1992-10-12 | 1994-11-25 | Synthelabo | Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique. |
CA2108245A1 (en) * | 1992-11-04 | 1994-05-05 | Gary J. Grover | Method for treating myocardial ischemia employing serotonin receptor antagonists |
EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
WO1997022583A1 (de) * | 1995-12-20 | 1997-06-26 | Eckhart Pein | Neue 1-phenylalkyl/alkylen-4-(.alpha.-hydroxydiphenylmethyl)-piperidin derivate und ihre verwendung als serotonin antagonisten |
US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
TWI249526B (en) * | 1998-03-13 | 2006-02-21 | Aventis Pharma Inc | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
SE9801516D0 (sv) * | 1998-04-30 | 1998-04-30 | Maria Carlsson | M100907/4-Piperidinemethanol derivatives for autism |
DE19934432A1 (de) | 1999-07-22 | 2001-02-01 | Merck Patent Gmbh | Indolderivate |
DE19939756A1 (de) * | 1999-08-21 | 2001-02-22 | Merck Patent Gmbh | Piperidinalkohole |
US7345096B2 (en) | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
US7402698B2 (en) | 2003-10-14 | 2008-07-22 | Wyeth | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use |
US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
US7531543B2 (en) | 2003-10-14 | 2009-05-12 | Wyeth | Phenylpiperazine cycloalkanol derivatives and methods of their use |
US7419980B2 (en) | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7524846B2 (en) | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
ES2515092T3 (es) | 2003-12-11 | 2014-10-29 | Sunovion Pharmaceuticals Inc. | Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión |
DE102004010132A1 (de) * | 2004-02-27 | 2005-09-15 | Merck Patent Gmbh | Piperidinderivate |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US20060069124A1 (en) * | 2004-09-07 | 2006-03-30 | Rao P S | Use of MDL-100,907 for treatment of allergic and eosinophil mediated diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3100775A (en) * | 1959-04-01 | 1963-08-13 | Searle & Co | alpha-phenyl(pyridyl or piperidyl)alkyl esters of (chloro or lower alkoxy)-benzoic acids and congeners |
ZA717147B (en) * | 1970-11-27 | 1972-07-26 | Richardson Merrell Inc | 4-(4-(alpha-hydroxybenzyl)piperidino)-4'-fluorobutyrophenone derivatives |
SE7409245L (es) * | 1973-07-19 | 1975-01-20 | Robins Co Inc A H | |
FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
-
1986
- 1986-06-26 ZA ZA864772A patent/ZA864772B/xx unknown
- 1986-06-26 CA CA000512511A patent/CA1280421C/en not_active Expired - Lifetime
- 1986-06-27 AU AU59318/86A patent/AU590582B2/en not_active Expired
- 1986-06-27 NZ NZ216689A patent/NZ216689A/xx unknown
- 1986-06-27 PH PH33962A patent/PH22141A/en unknown
- 1986-06-27 IL IL79266A patent/IL79266A/xx not_active IP Right Cessation
- 1986-06-30 GR GR861699A patent/GR861699B/el unknown
- 1986-07-01 EP EP86108941A patent/EP0208235B1/en not_active Expired - Lifetime
- 1986-07-01 PT PT82890A patent/PT82890B/pt unknown
- 1986-07-01 KR KR1019860005319A patent/KR900001184B1/ko not_active IP Right Cessation
- 1986-07-01 ES ES8600071A patent/ES2000299A6/es not_active Expired
- 1986-07-01 FI FI862801A patent/FI84474C/fi not_active IP Right Cessation
- 1986-07-01 CN CN86104408A patent/CN1023895C/zh not_active Expired - Lifetime
- 1986-07-01 JP JP61152855A patent/JPH0655720B2/ja not_active Expired - Lifetime
- 1986-07-01 NO NO862661A patent/NO167384C/no not_active IP Right Cessation
- 1986-07-01 AT AT86108941T patent/ATE49403T1/de not_active IP Right Cessation
- 1986-07-01 DK DK198603123A patent/DK174153B1/da not_active IP Right Cessation
- 1986-07-01 IE IE177186A patent/IE58460B1/en not_active IP Right Cessation
- 1986-07-01 DE DE8686108941T patent/DE3668167D1/de not_active Expired - Lifetime
- 1986-07-01 HU HU862738A patent/HU196058B/hu unknown
- 1986-07-02 AR AR86304417A patent/AR241904A1/es active
-
1990
- 1990-04-06 AR AR90316571A patent/AR242184A1/es active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2000299A6 (es) | Procedimiento para la preparaciom de nuevos derivados de n-aralquil-piperinmetanol | |
MX9704777A (es) | Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. | |
MY132229A (en) | Indole derivatives as 5-ht receptor antagonist | |
AU6223986A (en) | Potent,selective opioid receptor agonists and antagonists | |
MY104065A (en) | New pharmaceutical preparation | |
NO873133L (no) | Serotoninantagonister og fremgangsmaate for deres fremstilling. | |
CY1107494T1 (el) | Υποκατεστημενα παραγωγα πυριδυλμεθυλπιπepαζινης και πιπepιδινης, η παρασκευη τους και η χρηση τους για θepαπεια νοσων του κεντρικου νευρικου συστηματος (κνς) | |
MX11117A (es) | Procedimiento para la preparacion de nuevos antagonistas opioides de la piperidina. | |
BG102474A (en) | (-)-cis-6(s)-phenyl-5(r)-[4-(2-pyrrolidine-1-yletoxi)phenyl)-5,6,7 ,8-tetrahydronaphthalen-2-ol-d-tartarate | |
NO963731L (no) | Behandling av obsessive-kompulsive sykdommer med 5HT2-antagonister | |
EP0229444A3 (en) | Medicaments for the treatment of anxiety | |
ES2033516T3 (es) | Procedimiento para preparar 9 alfa-hidroxi-17 metileno-esteroides. | |
HK75993A (en) | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions | |
NO176016C (no) | Sementblanding, særlig egnet for sementering av borehull | |
ATE288268T1 (de) | Nichtpeptidische antagonisten des glp-1 rezeptors und verwendungsmethoden | |
NO963331L (no) | 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister | |
ES551843A0 (es) | Procedimiento para preparar dihidropiridinas. | |
MY107354A (en) | Substituted cyclohexenes as central nervous system agents | |
NO983860L (no) | Nye triazolopuriner, fremgangsmÕte for deres fremstilling og deres anvendelse som legemidler | |
NZ513053A (en) | (1-phenacy-3-phenyl-3-piperidylethyl)piperidine derivatives, method for the production thereof and pharmaceutical compositions containing the same | |
NZ226899A (en) | Enamine quaternary spiro derivatives, intermediates and process for production thereof, and muscle relaxant compositions containing them | |
EE03873B1 (et) | Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine | |
ATE56873T1 (de) | Verwendung von hygromycin und epihygromycin zur behandlung von dysentrie bei schweinen. | |
IS1380B6 (is) | Aðferð til að framleiða díhydrópyridín efnasambönd sem hafa lyfjaverkun og eru milliefni í framleiðslu þekktra háþrýstilyfja | |
PL338147A1 (en) | Derivatives of polyhydroxylbutylpyrazine, method of obtaining and drugs containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060703 |