KR870000313A - 벤조티아진 디옥사이드 유도체의 제조 방법 - Google Patents

벤조티아진 디옥사이드 유도체의 제조 방법 Download PDF

Info

Publication number
KR870000313A
KR870000313A KR1019860004341A KR860004341A KR870000313A KR 870000313 A KR870000313 A KR 870000313A KR 1019860004341 A KR1019860004341 A KR 1019860004341A KR 860004341 A KR860004341 A KR 860004341A KR 870000313 A KR870000313 A KR 870000313A
Authority
KR
South Korea
Prior art keywords
compound
methyl
benzothiazine
propionyloxy
pyridinyl
Prior art date
Application number
KR1019860004341A
Other languages
English (en)
Other versions
KR870000907B1 (ko
Inventor
조오지 롬바르디노 죠셉
Original Assignee
화이자 인코포레이티드
알렌 제이. 스피겔
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 인코포레이티드, 알렌 제이. 스피겔 filed Critical 화이자 인코포레이티드
Publication of KR870000313A publication Critical patent/KR870000313A/ko
Application granted granted Critical
Publication of KR870000907B1 publication Critical patent/KR870000907B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

벤조티아진 디옥사이드 유도체의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(II)의 옥시캄 화합물을 일반식(III)의 아실 할라이드와 반응시켜 일반식(I)의 화합물을 제조하는 방법.
    상기식에서 R은 2-피리딜, 6-메틸-2-피리딜, 6-플루오로-2-피리딜, 6-클로로-2-피리딜, 5-메틸-3-이소옥사졸릴 또는 2-티아졸릴이고, Y는 4-이소부틸페닐, 3-페녹시페닐, 3-벤조일페닐, 2-아세톡시페닐, 6-메톡시나프트-2-일 또는 2-플루오로-4-비페닐릴이며, Z는 -CH=CH- 또는 S이고, n은 0 또는 1이며, 단 이때 Y가 2-아세톡시페닐이 아닌 경우에 n은 1이고, Y가 2-아세톡시페닐인 경우에 n은 0이며, X는 염소 또는 브롬이다.
  2. 제1항에 있어서, 옥시캄 출발물질에 대하여 적어도 등몰량의 아실 할라이드를 사용하는 방법.
  3. 제1항에 있어서, 거의 무수 조건하에 반응 불활성 유기용매중에서 적어도 적절한 표준염기의 존재하에 반응을 수행하는 방법.
  4. 제3항에 있어서, 약 0℃ 내지 약 50℃에서 약 30분 내지 약 72시간 동안 반응을 수행하는 방법.
  5. 제3항에 있어서, 사용되는 용매가 할로겐화 저급 탄화수소이고, 사용되는 표준염기가 3급 아민인 방법.
  6. 제1항에 있어서, 제조되는 화합물이 4-[α-(4-이소부틸페닐) 프로피오닐옥시]-2-메틸-N-(2-피리디닐)-2H-1,2-벤조티아진-3-카복스아미드 1,1-디옥사이드인 방법.
  7. 제1항에 있어서, 제조되는 화합물이 4-[α-(3-벤조일페닐) 프로피오닐옥시]-2-메틸-N-(2-피리디닐)-2H-1,2-벤조티아진-3-카복스아미드 1,1-디옥사이드인 방법.
  8. 제1항에 있어서, 제조되는 화합물이 4-[α-(6-메톡시나프트-2-일) 프로피오닐옥시]-2-메틸-N-(2-피리디닐)-2H-1,2-벤조티아진-3-카복스아미드 1,1-디옥사이드인 방법.
  9. 제1항에 있어서, 제조되는 화합물이 2-메틸-4-[α-(3-페녹시페닐) 프로피오닐옥시]-N-(2-피리디닐)-2H-1,2-벤조티아진-3-카복스아미드 1,1-디옥사이드인 방법.
  10. 제1항에 있어서, 제조되는 화합물이 4-[α-(2-플루오로-4-비페닐릴) 프로피오닐옥시]-2-메틸-N-(2-피리디닐)-2H-1,2-벤조티아진-3-카복스아미드 1,1-디옥사이드인 방법.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019860004341A 1985-06-03 1986-06-02 벤조티아진 디옥사이드 유도체의 제조방법 KR870000907B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/740,466 US4610982A (en) 1985-06-03 1985-06-03 Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US740,466 1985-06-03
US740466 1985-06-03

Publications (2)

Publication Number Publication Date
KR870000313A true KR870000313A (ko) 1987-02-17
KR870000907B1 KR870000907B1 (ko) 1987-05-06

Family

ID=24976643

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004341A KR870000907B1 (ko) 1985-06-03 1986-06-02 벤조티아진 디옥사이드 유도체의 제조방법

Country Status (14)

Country Link
US (1) US4610982A (ko)
EP (1) EP0207622A3 (ko)
JP (1) JPS61282379A (ko)
KR (1) KR870000907B1 (ko)
AU (1) AU562653B2 (ko)
CA (1) CA1267896A (ko)
DK (1) DK258186A (ko)
ES (1) ES8707232A1 (ko)
FI (1) FI86066C (ko)
GR (1) GR861427B (ko)
HU (1) HU198206B (ko)
IL (1) IL78966A (ko)
PH (1) PH22241A (ko)
PL (1) PL146308B1 (ko)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3646020A (en) * 1970-07-16 1972-02-29 Warner Lambert Pharmaceutical 4-acyloxy-3-phenylcarbamyl-2h-1 2-benzothiazine 1 1-dioxides
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3704298A (en) * 1971-06-22 1972-11-28 Warner Lambert Co 4-acyloxy-3-(2-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,1-dioxides
US3788324A (en) * 1972-05-05 1974-01-29 P Lim External catheter device
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
JPS5714589A (en) * 1980-06-27 1982-01-25 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation and drug composition
JPS5770888A (en) * 1980-10-18 1982-05-01 Shinichi Ito Benzothiazine derivative, its preparation and medicinal composition
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
US4434164A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
IT1168064B (it) * 1981-11-12 1987-05-20 Prodotti Antibiotici Spa Composto ad azione antinfiammatoria
IT8219486A0 (it) * 1982-02-05 1982-02-05 Chiesi Farma Spa Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.
JPS59193879A (ja) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd トロポン誘導体
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬

Also Published As

Publication number Publication date
PH22241A (en) 1988-07-01
IL78966A0 (en) 1986-09-30
EP0207622A2 (en) 1987-01-07
AU5826186A (en) 1986-12-11
FI86066C (fi) 1992-07-10
DK258186A (da) 1986-12-04
GR861427B (en) 1986-09-26
FI862335A0 (fi) 1986-06-02
FI862335A (fi) 1986-12-04
JPS61282379A (ja) 1986-12-12
PL146308B1 (en) 1989-01-31
ES8707232A1 (es) 1987-07-16
IL78966A (en) 1990-08-31
HU198206B (en) 1989-08-28
EP0207622A3 (en) 1987-04-15
ES555669A0 (es) 1987-07-16
DK258186D0 (da) 1986-06-02
KR870000907B1 (ko) 1987-05-06
HUT43595A (en) 1987-11-30
US4610982A (en) 1986-09-09
FI86066B (fi) 1992-03-31
CA1267896A (en) 1990-04-17
AU562653B2 (en) 1987-06-18

Similar Documents

Publication Publication Date Title
DK444685A (da) Tiazolidindionderivater, farmaceutiske praeparater indeholdende dem ogfremgangsmaader til fremstilling deraf
KR870000323A (ko) 헤테로방향족 아민 유도체의 제조방법
KR860009012A (ko) 벤조티아진 디옥사이드 유도체의 제조방법
KR910000678A (ko) 신규의 티아졸릴알콕시아크릴레이트, 그의 제조방법, 살진균제로서의 용도 및 중간체 생성물
KR870000336A (ko) 알릴 에스텔과 에텔의 탈보호방법
FI963344A (fi) Menetelmä substituoitujen tiatsolien valmistamiseksi
KR860001819A (ko) 티아(옥사)디아졸 유도체의 제조방법
ATE221890T1 (de) Verfahren zur selektiven herstellung von z- isomeren von 3-(2-substituiertes vinyl)cephalosporinen
KR870000313A (ko) 벤조티아진 디옥사이드 유도체의 제조 방법
ES537633A0 (es) Un procedimiento para preparar un compuesto cefemico
KR900016212A (ko) 피리딜티아졸리딘 카복스아미드 유도체 및 이의 중간체, 및 이들의 제조방법
IE782028L (en) Substituted furans
KR860006472A (ko) 신규 세팔로스포린의 제조 방법
KR840006970A (ko) 벤질카르바모일 피리딘 유도체의 제조방법
KR850006198A (ko) 옥시캄 에스테르 유도체의 제조방법
KR890002113A (ko) 벤즈이미다졸 유도체
KR940009155A (ko) 2-치환된 5-알킬피리딘의 제조방법
KR840008647A (ko) 대칭 1,4-디하이드로피리딘디카복실 에스테르의 제조방법
KR860000295A (ko) 옥시캄 유도체의 제조방법
EP0946532B1 (en) Preparation of thiazoles
KR830009055A (ko) 치환된 페닐설포닐우레아 유도체 및 그의 중간물질의 제조방법
KR860000275A (ko) 히스타민 h_2-섭수체 길항작용을 가진 치환 3,4-디아미노-1,2,5-티아디아졸류의 제조방법
KR840000516A (ko) 아미도벤즈아미드류의 제법
KR870006063A (ko) 1-H-피리도-[3,2-b][1,4]-티아진 및 그의 제조방법
KR840000542A (ko) 벤조티아진 카복사미드의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20050408

Year of fee payment: 19

EXPY Expiration of term