JPS5770888A - Benzothiazine derivative, its preparation and medicinal composition - Google Patents
Benzothiazine derivative, its preparation and medicinal compositionInfo
- Publication number
- JPS5770888A JPS5770888A JP14588680A JP14588680A JPS5770888A JP S5770888 A JPS5770888 A JP S5770888A JP 14588680 A JP14588680 A JP 14588680A JP 14588680 A JP14588680 A JP 14588680A JP S5770888 A JPS5770888 A JP S5770888A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- benzothiazine
- preparation
- compound
- medicinal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of the formula [R1 is H, aliphatic or aromatic acyl; R2 is methyl or mono-, di- or trifluoromethyl; R3 is 2-(6-ethylpyridyl), 2-(6- trifluoromethylpyridyl), etc.].
EXAMPLE: N[2-(6-Ethylpyridyl)]-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dioxide.
USE: An anti-inflammatory agent characterized by the very low toxicity and long duration without giving gastric disorder.
PROCESS: A methyl-2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide is reacted with the corresponding amino compound in exlene under heating to give the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14588680A JPS5770888A (en) | 1980-10-18 | 1980-10-18 | Benzothiazine derivative, its preparation and medicinal composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14588680A JPS5770888A (en) | 1980-10-18 | 1980-10-18 | Benzothiazine derivative, its preparation and medicinal composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5770888A true JPS5770888A (en) | 1982-05-01 |
Family
ID=15395318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14588680A Pending JPS5770888A (en) | 1980-10-18 | 1980-10-18 | Benzothiazine derivative, its preparation and medicinal composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5770888A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5921682A (en) * | 1982-07-07 | 1984-02-03 | ジ−クフリ−ト・アクチエンゲゼルシヤフト | Manufacture of 4-hydroxy-2-methyl-n-2-pyridyl- 2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide |
JPS608282A (en) * | 1983-06-27 | 1985-01-17 | キエシ・フアルマチエウチチ・エツセ・ピ・ア | Benzo-1,2-thiazine-1,1-dioxide derivative, manufacture and medicine |
US4540692A (en) * | 1983-03-31 | 1985-09-10 | Fujisawa Pharmaceutical Co., Ltd. | Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use |
JPS61161281A (en) * | 1985-01-10 | 1986-07-21 | Grelan Pharmaceut Co Ltd | 1,2-benzothiazine-3-carboxamide derivative |
JPS61277683A (en) * | 1985-05-29 | 1986-12-08 | フアイザ−・インコ−ポレ−テツド | Benzothiazine dioxide derivative |
JPS61282379A (en) * | 1985-06-03 | 1986-12-12 | フアイザ−・インコ−ポレ−テツド | Benzothiazine dioxide derivative |
WO2010009212A1 (en) * | 2008-07-17 | 2010-01-21 | Schering Corporation | Niacin derivatives useful to treat metabolic syndromes |
-
1980
- 1980-10-18 JP JP14588680A patent/JPS5770888A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5921682A (en) * | 1982-07-07 | 1984-02-03 | ジ−クフリ−ト・アクチエンゲゼルシヤフト | Manufacture of 4-hydroxy-2-methyl-n-2-pyridyl- 2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide |
US4540692A (en) * | 1983-03-31 | 1985-09-10 | Fujisawa Pharmaceutical Co., Ltd. | Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use |
JPS608282A (en) * | 1983-06-27 | 1985-01-17 | キエシ・フアルマチエウチチ・エツセ・ピ・ア | Benzo-1,2-thiazine-1,1-dioxide derivative, manufacture and medicine |
JPS6311354B2 (en) * | 1983-06-27 | 1988-03-14 | Kieshi Pharm Spa | |
JPS61161281A (en) * | 1985-01-10 | 1986-07-21 | Grelan Pharmaceut Co Ltd | 1,2-benzothiazine-3-carboxamide derivative |
JPS61277683A (en) * | 1985-05-29 | 1986-12-08 | フアイザ−・インコ−ポレ−テツド | Benzothiazine dioxide derivative |
JPH0575754B2 (en) * | 1985-05-29 | 1993-10-21 | Pfizer | |
JPS61282379A (en) * | 1985-06-03 | 1986-12-12 | フアイザ−・インコ−ポレ−テツド | Benzothiazine dioxide derivative |
WO2010009212A1 (en) * | 2008-07-17 | 2010-01-21 | Schering Corporation | Niacin derivatives useful to treat metabolic syndromes |
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