JPS5770888A - Benzothiazine derivative, its preparation and medicinal composition - Google Patents

Benzothiazine derivative, its preparation and medicinal composition

Info

Publication number
JPS5770888A
JPS5770888A JP14588680A JP14588680A JPS5770888A JP S5770888 A JPS5770888 A JP S5770888A JP 14588680 A JP14588680 A JP 14588680A JP 14588680 A JP14588680 A JP 14588680A JP S5770888 A JPS5770888 A JP S5770888A
Authority
JP
Japan
Prior art keywords
methyl
benzothiazine
preparation
compound
medicinal composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14588680A
Other languages
Japanese (ja)
Inventor
Shinichi Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP14588680A priority Critical patent/JPS5770888A/en
Publication of JPS5770888A publication Critical patent/JPS5770888A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of the formula [R1 is H, aliphatic or aromatic acyl; R2 is methyl or mono-, di- or trifluoromethyl; R3 is 2-(6-ethylpyridyl), 2-(6- trifluoromethylpyridyl), etc.].
EXAMPLE: N[2-(6-Ethylpyridyl)]-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dioxide.
USE: An anti-inflammatory agent characterized by the very low toxicity and long duration without giving gastric disorder.
PROCESS: A methyl-2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide is reacted with the corresponding amino compound in exlene under heating to give the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP14588680A 1980-10-18 1980-10-18 Benzothiazine derivative, its preparation and medicinal composition Pending JPS5770888A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14588680A JPS5770888A (en) 1980-10-18 1980-10-18 Benzothiazine derivative, its preparation and medicinal composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14588680A JPS5770888A (en) 1980-10-18 1980-10-18 Benzothiazine derivative, its preparation and medicinal composition

Publications (1)

Publication Number Publication Date
JPS5770888A true JPS5770888A (en) 1982-05-01

Family

ID=15395318

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14588680A Pending JPS5770888A (en) 1980-10-18 1980-10-18 Benzothiazine derivative, its preparation and medicinal composition

Country Status (1)

Country Link
JP (1) JPS5770888A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921682A (en) * 1982-07-07 1984-02-03 ジ−クフリ−ト・アクチエンゲゼルシヤフト Manufacture of 4-hydroxy-2-methyl-n-2-pyridyl- 2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide
JPS608282A (en) * 1983-06-27 1985-01-17 キエシ・フアルマチエウチチ・エツセ・ピ・ア Benzo-1,2-thiazine-1,1-dioxide derivative, manufacture and medicine
US4540692A (en) * 1983-03-31 1985-09-10 Fujisawa Pharmaceutical Co., Ltd. Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use
JPS61161281A (en) * 1985-01-10 1986-07-21 Grelan Pharmaceut Co Ltd 1,2-benzothiazine-3-carboxamide derivative
JPS61277683A (en) * 1985-05-29 1986-12-08 フアイザ−・インコ−ポレ−テツド Benzothiazine dioxide derivative
JPS61282379A (en) * 1985-06-03 1986-12-12 フアイザ−・インコ−ポレ−テツド Benzothiazine dioxide derivative
WO2010009212A1 (en) * 2008-07-17 2010-01-21 Schering Corporation Niacin derivatives useful to treat metabolic syndromes

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921682A (en) * 1982-07-07 1984-02-03 ジ−クフリ−ト・アクチエンゲゼルシヤフト Manufacture of 4-hydroxy-2-methyl-n-2-pyridyl- 2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide
US4540692A (en) * 1983-03-31 1985-09-10 Fujisawa Pharmaceutical Co., Ltd. Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use
JPS608282A (en) * 1983-06-27 1985-01-17 キエシ・フアルマチエウチチ・エツセ・ピ・ア Benzo-1,2-thiazine-1,1-dioxide derivative, manufacture and medicine
JPS6311354B2 (en) * 1983-06-27 1988-03-14 Kieshi Pharm Spa
JPS61161281A (en) * 1985-01-10 1986-07-21 Grelan Pharmaceut Co Ltd 1,2-benzothiazine-3-carboxamide derivative
JPS61277683A (en) * 1985-05-29 1986-12-08 フアイザ−・インコ−ポレ−テツド Benzothiazine dioxide derivative
JPH0575754B2 (en) * 1985-05-29 1993-10-21 Pfizer
JPS61282379A (en) * 1985-06-03 1986-12-12 フアイザ−・インコ−ポレ−テツド Benzothiazine dioxide derivative
WO2010009212A1 (en) * 2008-07-17 2010-01-21 Schering Corporation Niacin derivatives useful to treat metabolic syndromes

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