KR870000309A - 항과민성 및 항기관지경련성 n-벤즈히드릴 디아자시클로 알킬알칸 아닐리드의 제조 방법 - Google Patents
항과민성 및 항기관지경련성 n-벤즈히드릴 디아자시클로 알킬알칸 아닐리드의 제조 방법 Download PDFInfo
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- KR870000309A KR870000309A KR1019860004899A KR860004899A KR870000309A KR 870000309 A KR870000309 A KR 870000309A KR 1019860004899 A KR1019860004899 A KR 1019860004899A KR 860004899 A KR860004899 A KR 860004899A KR 870000309 A KR870000309 A KR 870000309A
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- benzhydryl
- piperazinyl
- amide
- aminophenyl
- alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- N-벤즈히드릴 피페라진(Ⅱ)을 적당한 용매 중에서 50∼100℃의 온도로 수시간 동안 하기 일반식(Ⅲ)의 아크릴로일아닐리드 유도체 또는 하기 일반식(Ⅳ)의 화합물과 반응시키고, 수득된 생성물을 분리 및 정제함을 특징으로 하는 일반식(Ⅰ)의 화합물, 그의 이 성질체 혼합물, 각 거울상 이성질체 및 약학적으로 수용 가능한 그 염의 제조방법.(식중, R은 수소 또는 1∼4 탄소원자를 갖는 알킬이고, A-는 1∼4 탄소원자를 갖는 직쇄 또는 측쇄 알킬이며, R1및 R2는 각각 수소, 아미노, 알킬아미노, 디알킬아미노, 알킬기에 1∼4 탄소원자를 갖는 모노 및 디(히드록시 알킬) 아미노, 모르폴리노, 피페리디노, N-알킬 피페라지노, 1,3-디티올란-2-일리덴아미노 및 N-알킬 우레이도이고, R3및 R4는 수소 또는 저급알킬이며, n은 1∼5의 숫자이다).
- 제1항에 있어서, 목적 생성물이 3-(4-벤즈히드릴-1-피페라지닐)-N,4-디에틸 아미노페닐 프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-(1-모르폴리노) 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-(1-피페리디노) 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,3-디메틸 아미노페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-디메틸 아미노페닐 프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N-메틸-N,4-디메틸 아미노페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N-(4, 비스-(2-히드록시에틸)아미노페닐 프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-디메틸 아미노페닐부티르 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-(4-메틸-1-피페라지닐) 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-(1-이미다졸릴) 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,3-아미노페닐 프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-아미노페닐 프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-메틸우레이도 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-디메틸아미노페닐 부티르아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,3-메틸아미노 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,4-메틸아미노 페닐프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,3-아미노페닐-N-메틸프로피온 아미드, 3-(4-벤즈히드릴-1-피페라지닐)-N,3-(1,2-디티올란-2-일를덴) 아미노페닐프로피온 아미드, 2-메틸-3(4-벤즈히드릴-1-피페라지닐) -N,4-디메틸아미노 페닐프로피온 아미드인 방법.
- 제1항에 있어서, 용매가 디메틸포름아미드, 톨루엔 또는 크실렌중에서 선택된 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21225/85A IT1190375B (it) | 1985-06-20 | 1985-06-20 | N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica |
IT21225/85 | 1985-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870000309A true KR870000309A (ko) | 1987-02-17 |
Family
ID=11178661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860004899A KR870000309A (ko) | 1985-06-20 | 1986-06-19 | 항과민성 및 항기관지경련성 n-벤즈히드릴 디아자시클로 알킬알칸 아닐리드의 제조 방법 |
Country Status (24)
Country | Link |
---|---|
US (1) | US4675319A (ko) |
EP (1) | EP0207901B1 (ko) |
JP (1) | JPS61293977A (ko) |
KR (1) | KR870000309A (ko) |
CN (1) | CN1011784B (ko) |
AR (1) | AR241591A1 (ko) |
AT (1) | ATE58729T1 (ko) |
AU (1) | AU592348B2 (ko) |
CA (1) | CA1269980A (ko) |
DE (1) | DE3675824D1 (ko) |
DK (1) | DK291186A (ko) |
ES (1) | ES8708218A1 (ko) |
FI (1) | FI862204A (ko) |
GR (1) | GR861391B (ko) |
HU (1) | HU198033B (ko) |
IL (1) | IL78804A (ko) |
IT (1) | IT1190375B (ko) |
NO (1) | NO163816C (ko) |
NZ (1) | NZ216547A (ko) |
PH (1) | PH22809A (ko) |
PT (1) | PT82810B (ko) |
SG (1) | SG7292G (ko) |
TN (1) | TNSN86090A1 (ko) |
ZA (1) | ZA863754B (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990010329A (ko) * | 1997-07-16 | 1999-02-18 | 레나르트 태퀴스트 | 실리콘 질화물 절삭 공구 재료 |
KR100384241B1 (ko) * | 2000-10-31 | 2003-05-16 | (주) 기산테크 | 저활동성 플라즈마 이온 방전을 이용한 오존발생장치 |
Families Citing this family (28)
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JPH0660160B2 (ja) * | 1985-12-13 | 1994-08-10 | テルモ株式会社 | アミド誘導体およびこれを含有する抗アレルギ−剤 |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
US4745191A (en) * | 1987-09-30 | 1988-05-17 | American Home Products Corporation | 1-((A-substituted phenyl-ω-substituted piperazinyl)alkenyl) cyclohexanol |
EP0598123A4 (en) * | 1991-07-19 | 1995-02-15 | Zeria Pharm Co Ltd | PIPERAZINE DERIVATIVE AND MEDICINAL PRODUCT CONTAINING THE SAME. |
AU753360B2 (en) | 1998-07-31 | 2002-10-17 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
MX2009003850A (es) * | 2006-10-09 | 2009-04-23 | Clariant Finance Bvi Ltd | Metodo para producir alcanol amidas de acido graso. |
DE102006047618B3 (de) * | 2006-10-09 | 2007-11-15 | Clariant International Limited | Verfahren zur Herstellung von Bisbenzoxazolen |
DE102006047617B4 (de) * | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung basischer (Meth)acrylamide |
DE102006047619B4 (de) * | 2006-10-09 | 2008-11-13 | Clariant International Limited | Verfahren zur Herstellung basischer Fettsäureamide |
DE102006047620B4 (de) | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung tertiärer Amide von Alkylphenylcarbonsäuren |
KR101079459B1 (ko) * | 2007-09-14 | 2011-11-03 | 이화여자대학교 산학협력단 | 신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물 |
DE102008017215B4 (de) * | 2008-04-04 | 2012-08-09 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Amiden ethylenisch ungesättigter Carbonsäuren |
DE102008017214B4 (de) * | 2008-04-04 | 2012-02-16 | Clariant International Limited | Kontinuierliches Verfahren zur Herstellung von Fettsäurealkanolamiden |
DE102008017216B4 (de) * | 2008-04-04 | 2013-08-14 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden |
DE102008017213B4 (de) * | 2008-04-04 | 2012-08-09 | Clariant International Limited | Kontinuierliches Verfahren zur Herstellung von Amiden aliphatischer Hydroxycarbonsäuren |
DE102008017217A1 (de) * | 2008-04-04 | 2009-10-08 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Amiden aromatischer Carbonsäuren |
DE102008017219A1 (de) * | 2008-04-04 | 2009-10-08 | Clariant International Ltd. | Verfahren zur Herstellung von Amiden in Gegenwart von überhitztem Wasser |
DE102008017218B4 (de) * | 2008-04-04 | 2011-09-22 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Amiden niederer aliphatischer Carbonsäuren |
CN101429164B (zh) * | 2008-11-14 | 2013-03-20 | 广西大学 | 左旋二苯甲基哌嗪衍生物及其制备方法 |
DE102009031059A1 (de) | 2009-06-30 | 2011-01-05 | Clariant International Ltd. | Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen |
DE102009042522A1 (de) | 2009-09-22 | 2011-04-07 | Clariant International Ltd. | Kontinuierliches Umesterungsverfahren |
DE102009042523B4 (de) | 2009-09-22 | 2012-02-16 | Clariant International Ltd. | Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen |
DE102010056565A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere |
DE102010056564A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Limited | Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung |
WO2017066705A1 (en) * | 2015-10-14 | 2017-04-20 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
CN114621101A (zh) * | 2020-12-11 | 2022-06-14 | 李冰坚 | 一种3,5-二甲基-1,2-苯二胺二盐酸盐的精制方法 |
Family Cites Families (9)
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US3244718A (en) * | 1964-02-17 | 1966-04-05 | Biel John Hans | Piperazine derivatives |
NL137318C (ko) * | 1964-06-09 | |||
DE2304154A1 (de) * | 1973-01-29 | 1974-08-01 | Ichthyol Ges Cordes Hermanni & | Verfahren zur herstellung von substituierten piperazin- bzw. homopiperazinderivaten |
JPS5070389A (ko) * | 1973-10-30 | 1975-06-11 | ||
GB2056968A (en) * | 1979-08-21 | 1981-03-25 | Fujisawa Pharmaceutical Co | Piperazine derivative, processes for the preparation thereof and pharmaceutical composition comprising the same |
US4411900A (en) * | 1980-01-03 | 1983-10-25 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical composition comprising the same |
JPS59118765A (ja) * | 1982-12-24 | 1984-07-09 | Fujisawa Pharmaceut Co Ltd | ピペラジン誘導体 |
GB8303946D0 (en) * | 1983-02-12 | 1983-03-16 | Recordati Chem Pharm | Antihypertensive n-piperazinylalkanoylanilides |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1985
- 1985-06-20 IT IT21225/85A patent/IT1190375B/it active
-
1986
- 1986-05-16 IL IL78804A patent/IL78804A/xx not_active IP Right Cessation
- 1986-05-20 ZA ZA863754A patent/ZA863754B/xx unknown
- 1986-05-26 FI FI862204A patent/FI862204A/fi not_active Application Discontinuation
- 1986-05-28 GR GR861391A patent/GR861391B/el unknown
- 1986-06-02 CA CA000510539A patent/CA1269980A/en not_active Expired - Fee Related
- 1986-06-09 US US06/871,858 patent/US4675319A/en not_active Expired - Fee Related
- 1986-06-12 JP JP61137260A patent/JPS61293977A/ja active Pending
- 1986-06-16 NZ NZ216547A patent/NZ216547A/xx unknown
- 1986-06-17 ES ES556145A patent/ES8708218A1/es not_active Expired
- 1986-06-18 PH PH33900A patent/PH22809A/en unknown
- 1986-06-18 TN TNTNSN86090A patent/TNSN86090A1/fr unknown
- 1986-06-18 NO NO862427A patent/NO163816C/no unknown
- 1986-06-19 AU AU58828/86A patent/AU592348B2/en not_active Ceased
- 1986-06-19 KR KR1019860004899A patent/KR870000309A/ko not_active Application Discontinuation
- 1986-06-19 DE DE8686830172T patent/DE3675824D1/de not_active Expired - Fee Related
- 1986-06-19 CN CN86105641A patent/CN1011784B/zh not_active Expired
- 1986-06-19 EP EP86830172A patent/EP0207901B1/en not_active Expired - Lifetime
- 1986-06-19 HU HU862581A patent/HU198033B/hu not_active IP Right Cessation
- 1986-06-19 AT AT86830172T patent/ATE58729T1/de not_active IP Right Cessation
- 1986-06-19 AR AR86304331A patent/AR241591A1/es active
- 1986-06-20 PT PT82810A patent/PT82810B/pt not_active IP Right Cessation
- 1986-06-20 DK DK291186A patent/DK291186A/da not_active Application Discontinuation
-
1992
- 1992-01-25 SG SG72/92A patent/SG7292G/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990010329A (ko) * | 1997-07-16 | 1999-02-18 | 레나르트 태퀴스트 | 실리콘 질화물 절삭 공구 재료 |
KR100384241B1 (ko) * | 2000-10-31 | 2003-05-16 | (주) 기산테크 | 저활동성 플라즈마 이온 방전을 이용한 오존발생장치 |
Also Published As
Publication number | Publication date |
---|---|
HUT43837A (en) | 1987-12-28 |
DE3675824D1 (de) | 1991-01-10 |
US4675319A (en) | 1987-06-23 |
NO862427L (no) | 1986-12-22 |
AU5882886A (en) | 1986-12-24 |
NO163816C (no) | 1990-07-25 |
ES556145A0 (es) | 1987-10-01 |
CN86105641A (zh) | 1987-04-01 |
IL78804A0 (en) | 1986-09-30 |
FI862204A0 (fi) | 1986-05-26 |
CN1011784B (zh) | 1991-02-27 |
JPS61293977A (ja) | 1986-12-24 |
SG7292G (en) | 1992-03-20 |
GR861391B (en) | 1986-09-16 |
CA1269980A (en) | 1990-06-05 |
EP0207901B1 (en) | 1990-11-28 |
NZ216547A (en) | 1989-11-28 |
HU198033B (en) | 1989-07-28 |
AR241591A1 (es) | 1992-09-30 |
IT1190375B (it) | 1988-02-16 |
PT82810B (pt) | 1988-04-21 |
ATE58729T1 (de) | 1990-12-15 |
ES8708218A1 (es) | 1987-10-01 |
PH22809A (en) | 1988-12-27 |
NO163816B (no) | 1990-04-17 |
FI862204A (fi) | 1986-12-21 |
EP0207901A1 (en) | 1987-01-07 |
NO862427D0 (no) | 1986-06-18 |
IL78804A (en) | 1991-12-15 |
TNSN86090A1 (fr) | 1990-01-01 |
DK291186D0 (da) | 1986-06-20 |
PT82810A (en) | 1986-07-01 |
DK291186A (da) | 1986-12-21 |
ZA863754B (en) | 1987-01-28 |
AU592348B2 (en) | 1990-01-11 |
IT8521225A0 (it) | 1985-06-20 |
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