KR860009035A - 11-β 치환된 스테로이드의 제조방법 - Google Patents

11-β 치환된 스테로이드의 제조방법 Download PDF

Info

Publication number
KR860009035A
KR860009035A KR1019860004283A KR860004283A KR860009035A KR 860009035 A KR860009035 A KR 860009035A KR 1019860004283 A KR1019860004283 A KR 1019860004283A KR 860004283 A KR860004283 A KR 860004283A KR 860009035 A KR860009035 A KR 860009035A
Authority
KR
South Korea
Prior art keywords
group
alkyl
hydrogen
compound
together form
Prior art date
Application number
KR1019860004283A
Other languages
English (en)
Korean (ko)
Inventor
파우스티니 프랑코
달레시오 로베르토
빌라 비토리아
살레 엔리코디
Original Assignee
비토리노 페라리오
팔미탈리아 카를로 에르바에스. 피. 에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 비토리노 페라리오, 팔미탈리아 카를로 에르바에스. 피. 에이 filed Critical 비토리노 페라리오
Publication of KR860009035A publication Critical patent/KR860009035A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019860004283A 1985-05-31 1986-05-30 11-β 치환된 스테로이드의 제조방법 KR860009035A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8513723 1985-05-31
GB858513723A GB8513723D0 (en) 1985-05-31 1985-05-31 11-beta substituted steroids

Publications (1)

Publication Number Publication Date
KR860009035A true KR860009035A (ko) 1986-12-19

Family

ID=10579949

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004283A KR860009035A (ko) 1985-05-31 1986-05-30 11-β 치환된 스테로이드의 제조방법

Country Status (21)

Country Link
JP (1) JPS6212796A (de)
KR (1) KR860009035A (de)
AU (1) AU587031B2 (de)
BE (1) BE904846A (de)
CH (1) CH669385A5 (de)
DE (1) DE3617883A1 (de)
DK (1) DK251386A (de)
ES (1) ES8707972A1 (de)
FI (1) FI862278A (de)
FR (1) FR2582654B1 (de)
GB (2) GB8513723D0 (de)
GR (1) GR861405B (de)
HU (1) HU197925B (de)
IL (1) IL78957A (de)
IT (1) IT1190014B (de)
NL (1) NL8601387A (de)
NZ (1) NZ216325A (de)
PT (1) PT82665B (de)
SE (1) SE8602449L (de)
SU (1) SU1508963A3 (de)
ZA (1) ZA864065B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289073B1 (de) * 1987-04-24 1991-11-27 Akzo N.V. 11-Arylestranderivate und 11-Arylpregnanderivate
EP0321010B1 (de) * 1987-12-12 1993-02-03 Akzo N.V. 11-Arylsteroid-Derivate
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2665901B2 (fr) * 1989-02-24 1994-07-29 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH488682A (de) * 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
FR205F (de) * 1965-10-22
FR5913M (de) * 1965-12-02 1968-04-01
NL128375C (de) * 1966-02-18
FR2054527B1 (de) * 1969-07-28 1973-06-08 Roussel Uclaf
FR2054525B1 (de) * 1969-07-28 1973-01-12 Roussel Uclaf
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
NZ214998A (en) * 1985-02-07 1989-06-28 Schering Ag 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions

Also Published As

Publication number Publication date
ES555298A0 (es) 1987-09-01
AU587031B2 (en) 1989-08-03
SU1508963A3 (ru) 1989-09-15
BE904846A (fr) 1986-12-01
ZA864065B (en) 1987-01-28
PT82665B (pt) 1988-08-17
IT1190014B (it) 1988-02-10
FI862278A (fi) 1986-12-01
DE3617883A1 (de) 1986-12-04
IT8620598A1 (it) 1987-11-28
GR861405B (en) 1986-09-26
GB8513723D0 (en) 1985-07-03
GB2175905A (en) 1986-12-10
FI862278A0 (fi) 1986-05-29
NL8601387A (nl) 1986-12-16
CH669385A5 (de) 1989-03-15
FR2582654B1 (fr) 1988-06-03
PT82665A (en) 1986-06-01
JPS6212796A (ja) 1987-01-21
HUT44575A (en) 1988-03-28
SE8602449D0 (sv) 1986-05-29
ES8707972A1 (es) 1987-09-01
IL78957A (en) 1990-11-29
GB2175905B (en) 1989-01-18
FR2582654A1 (fr) 1986-12-05
IT8620598A0 (it) 1986-05-28
HU197925B (en) 1989-06-28
DK251386D0 (da) 1986-05-29
SE8602449L (sv) 1986-12-01
NZ216325A (en) 1989-01-27
GB8612866D0 (en) 1986-07-02
AU5806286A (en) 1986-12-04
DK251386A (da) 1986-12-01
IL78957A0 (en) 1986-09-30

Similar Documents

Publication Publication Date Title
KR870001228A (ko) 디스타마이신 A(Distamycin A) 유도체의 제조 방법
PT89185A (pt) Processo de preparacao de compostos 11-aril-esteroides e de composicoes farmaceuticas que os contem
KR860009035A (ko) 11-β 치환된 스테로이드의 제조방법
KR900018048A (ko) 환 치환된 2-아미노-1,2,3,4-테트라하이드로나프탈렌
ES390121A1 (es) Un procedimiento para la preparacion de composiciones fun- gicidas.
JPS5277073A (en) 1-carbamoyl-5-fluorouracil deruvative and anticancer drug containing s ame as effective component
IE822551L (en) Alkanes and alkenes
KR880005079A (ko) 3-아미노카르보닐-1,4-디히드로피리딘-5-카르복실산 화합물, 그의 제조방법, 및 그를 함유하는 약학조성물
JPS5212109A (en) Process for preparation of alkylglycerylether
KR880013938A (ko) 활성 화합물들
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
KR880012560A (ko) 치환된 피라졸의 합성방법
ES397453A1 (es) Procedimiento para la preparacion de derivados de imidazo- lina.
FR2412555A1 (fr) Composes polyfluorohydroxyisopropyl carbostyriles tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant
CH610184A5 (en) Systemic fungicidal and insecticidal composition
JPS525782A (en) Preparation of 1-phthalazinone
IL70552A0 (en) Aminoethoxybenzyl alcohol derivatives,their preparation and pharmaceutical compositions containing them
JPS5265299A (en) Synthesis of 2-substituted-thioadenosine-n-oxides
JPS5268182A (en) Preparation of novel triazole derivatives
JPS5651421A (en) Stabilization of prenyl halide
GB1455543A (en) Substituted 4,4-dicyclohexylmethane derivatives and microbicidal preparations containing them
JPS5231093A (en) Preparation of 3- methylenecephalosporanic acid derivatives
GB974981A (en) Esters of 5,7-dibromo-8-hydroxyquinoline and the preparation thereof
JPS5233648A (en) Preparation of 3',4',-dideoxy-3',4',-didehydro-butyrosine derivatives
JPS5283434A (en) Preparation of cyclopropylcarbinol derivatives

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid