KR860003217A - 복소환식 아미드의 제법 - Google Patents

복소환식 아미드의 제법 Download PDF

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KR860003217A
KR860003217A KR1019850007730A KR850007730A KR860003217A KR 860003217 A KR860003217 A KR 860003217A KR 1019850007730 A KR1019850007730 A KR 1019850007730A KR 850007730 A KR850007730 A KR 850007730A KR 860003217 A KR860003217 A KR 860003217A
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드레드릭 제프레이 브라운 (외 2)
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원본미기재
아이씨아이 아메리카스 아이엔씨
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Abstract

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Description

복소환식 아미드의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

  1. (a) Ri가 임의로, 아세톡시, (1-4C)알콕시 또는 (1-C)알킬티오 치환체를 갖는 (1-6C)알킬, 또는 페닐 또는 벤질인 구조식(5)의 적당한 에스테르를 분해하여 Z가 카복실산 그룹인 구조식(1)
  3. 의 화합물로 만들고; (b) 구조식(6)의 아민을 아실화하여,
  5. Re, Lo1 Re.X.CO.NH- 또는 Re.X.CS.NH- 그룹인 구조식(1)의 화합물로 만들고; (c) A가 -CH= 또는 -N=인 구조식(7)의 인돌 또는 인다졸 유도체를
  7. U가 적당한 이탈기인 구조식(8)의 알킬화제와 반응시켜,
  9. A.CRa가 디래디칼 -CRb=CRa- 또는 -N-CRa인 구조식(1)의 화합물로 만들고; (d) 구조식(9)의 시아노 유도체를 아지와 반응시켜,
  11. Z가 1(H)-테트라졸-5-일 래디칼인 구조식(1)의 화합물로 만들고; (e) Ra가 수소인 구조식(1)의 화합물을 할로겐하여, Ra가 할노게노인 구조식(1)의 화합물로 만들고; (f) Xb가 산소 또는 황인 구조식(10)의 이소시아네이트 또는 이소티오시아네이트를 Re,XH의 적당한 화합물과 반응시켜
  13. Re.L Re. X. CO. NH- 또는 Re. X. CS. NH-이고 X가 옥시 또는 티오인 구조식(1)의 화합물로 만들고; (g) Z가 카복시인 구조식(1)의 화합물을 Rg. SOnNH2의 설폰아미드 유도체와 반응시켜, Z가 -CO. NH. SOn. Rg인 구조식(1)의 화합물로 만들고; (h) Ra가 ((1-6C)알콕시)카보닐 및/또는 ((1-6C)알콜시카보닐-(1-3C))알킬 또는 ((1-6C)알콜시카보닐페닐)메틸을 가지는 구조식(1)의 에스테르를 분해하여, Ra가 카복시 치환제를 가지고 및/또는 Rh가 카복시-(1-3C)알킬 또는 (카복시페닐메틸인 구조식(1)의 상응하는 화합물로 만들고; (i) Xb가 옥시 또는 티오인 구조식(1)의 화합물을
  15. 이소시아네이트 유도체 ONC. SOn. Ra와 반응시켜, Z가 아실설폰아미드인 CO. NH. SOn. Rg그룹이고 G2가 Z에 직접 결합하고 Q가 산소 또는 황인 구조식(1)의 화합물로 만들고, (j) Z가 CO. NH. SO. Rg 그룹인 구조식(1)의 아실설핀아미드를 산화하여, Z가 CO. NH. SOn. Rg의 아실설폰아미드그룹인 구조식(1)의 상응하는 화합물로 만들고 (k) Ra가 임의로 카복시 또는 ((1-4C)알콕시)카보닐 치환제를 가지는 (2-6C)알케닐인 구조식(1)의 화합물을 환원하여, Ra가 임의로 카복시 또는 ((1-4C)알콕시)카보닐 치환체를 가지는 (2-6C)알킬인 구조식(1)의 화합물로 만드는; 것을 특징으로 하는 구조식(1)의 아미드 화합물을 제조하는 방법.
  17. [식중, A CRa는 -CRb=CRa-, -CHRb, CHRa- 및 -N=CRa-의 디래디칼에서 선택 Ra는 수소, 메틸, 할로게노, (2-6C)알카노일 임의로 카복시 또는 ((1-4C)알콕시)카보닐 치환제를 가지는 (2-6C)알케닐 또는 (2-6C)알킬 Rb는 수소 또는 (1-4C)알킬 또는 Ra 및 Rb는 임의로 1 또는 2(1-4C)알킬 치환제 및 임의로 1 또는 그 불포화결합을 포함하는 테트라메틸렌을 함께 형성 Rc,Rd 및 Rf는 수소, 할로게노(1-4C)알킬 및 (1-4C)알콕시에서 독립적으로 선택, Re. L은 벤지노이드환의 4,5 또는 6위치에 부착된 Ce. X. CO. NH-, Re. X. CS. NH- 또는 Re. NH. CO-의 아미드 래디칼, Re는 1 또는 그 이상의 불소치환제를 임의로 포함하는 (2-10C)알킬; (3-10C)알케닐 또는 (3-10C)알키닐, (1-6C)알킬부분은 (1-4C)알콕시, (3-6C)싸이클로알킬 또는 페닐치환제를 임의로 포함하고, 페닐 또는 티에닐부분은 할로게노, (1-4C)알킬, (1-4C)알콕시 및 트리플루오로메틸에서 선택된 1 또는 2치환제를 임의로 포함하는 페닐, 페닐-(1-6C)알킬 또는 티에닐-(1-6C)알킬; 싸이클 부분은 하나의 불포화결합 또는 1 또는 2(1-4C)알킬치환제 또는 페닐치환제를 포함하고, 페닐치환제는 할로게노, (1-4C)알킬, (1-4C)알콕시 또는 트리플루오로메틸 치환제를 임의로 갖는 (3-8C)싸이클로알킬, (3-8C)싸이클로알킬-(1-6C)알킬 또는 (4-6C)옥시헤테로싸이클릴, X는 옥시, 티오, 아미노 또는 Re에 직접결합, Q는 G1에 직접결합 또는 옥시, 티오, m-페닐렌, p-페닐렌 또는 헤테로아릴렌, G1은 (1-8C)알킬렌 또는 (2-6C)알케닐렌 G2는 메틸렌, 비틸렌 또는 Z에 직접결합, Z는 n이 1 또는 그이고 Rg가 방향족 또는 헤테로방향족 부분은 할로게노, (1-4C)알킬(1-4C)알콕시, 트리플루오로메틸, 니트로 및 아미노에서 독립적으로 선택된 1 또는 2치환제를 임의로 포함하는 (1-6C)알킬, 아릴, 헤테로아릴, 아릴-(1-4C)알킬이고 Rh는 수소, 카복시-(1-3C)알킬 또는 (카복시페닐)메틸인-CO.NH. SOn. Rg의 알실설폰아미드 잔사, 구조식(2)의 테트라졸릴 및 카복시에서 선택된 산성그룹.
  19. Q가 옥시 또는 티오 및 Z가 카복시일 때 G2가 메틸렌 또는 비닐렌이고, G1.Q 및 G2는 최소한 3탄소원자를 함께 포함.]
  20. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007730A 1984-10-19 1985-10-19 복소환식 아미드 및 그 제조방법 KR900007419B1 (ko)

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GB848426474A GB8426474D0 (en) 1984-10-19 1984-10-19 Heterocyclic amides
GB8426474 1984-10-19
GB8507305 1985-03-21
GB858507305A GB8507305D0 (en) 1985-03-21 1985-03-21 Amide derivatives
GB858507861A GB8507861D0 (en) 1985-03-26 1985-03-26 Carboxylic acid derivatives
GB8507861 1985-03-26
GB8507862 1985-03-26
GB858507862A GB8507862D0 (en) 1985-03-26 1985-03-26 Carboxamides

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KR900007419B1 KR900007419B1 (ko) 1990-10-08

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PT81297B (pt) 1987-11-30
IE58848B1 (en) 1993-11-17
HU194163B (en) 1988-01-28
ES548011A0 (es) 1987-04-01
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CA1273934A (en) 1990-09-11
NZ213872A (en) 1989-11-28
ES8800899A1 (es) 1987-12-01
IE852589L (en) 1986-04-19
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HUT38905A (en) 1986-07-28
DK479385A (da) 1986-04-20
NO854163L (no) 1986-04-21
JPS61178963A (ja) 1986-08-11
GR852519B (ko) 1986-01-24
ZW18185A1 (en) 1987-05-20
CN85108623A (zh) 1986-07-30
DK169541B1 (da) 1994-11-28
EP0179619A1 (en) 1986-04-30
GB8524157D0 (en) 1985-11-06
DK479385D0 (da) 1985-10-18
ES8801786A1 (es) 1988-02-16
DE3579554D1 (de) 1990-10-11
ATE56205T1 (de) 1990-09-15
ES554580A0 (es) 1988-02-16
KR900007419B1 (ko) 1990-10-08
IL76756A (en) 1989-05-15
FI854024A0 (fi) 1985-10-16
ES554577A0 (es) 1987-12-01
PT81297A (en) 1985-11-01
EP0179619B1 (en) 1990-09-05
ES8800900A1 (es) 1987-12-01
JPH0745466B2 (ja) 1995-05-17
FI854024L (fi) 1986-04-20
US4997844A (en) 1991-03-05
ES8704458A1 (es) 1987-04-01
ES8802495A1 (es) 1988-06-16

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