ES8800900A1 - Procedimiento para preparar derivados de amidoindol y amidoindazol - Google Patents

Procedimiento para preparar derivados de amidoindol y amidoindazol

Info

Publication number
ES8800900A1
ES8800900A1 ES554578A ES554578A ES8800900A1 ES 8800900 A1 ES8800900 A1 ES 8800900A1 ES 554578 A ES554578 A ES 554578A ES 554578 A ES554578 A ES 554578A ES 8800900 A1 ES8800900 A1 ES 8800900A1
Authority
ES
Spain
Prior art keywords
formula
compounds
cra
group
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554578A
Other languages
English (en)
Other versions
ES554578A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848426474A external-priority patent/GB8426474D0/en
Priority claimed from GB858507305A external-priority patent/GB8507305D0/en
Priority claimed from GB858507862A external-priority patent/GB8507862D0/en
Priority claimed from GB858507861A external-priority patent/GB8507861D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Publication of ES8800900A1 publication Critical patent/ES8800900A1/es
Publication of ES554578A0 publication Critical patent/ES554578A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE AMIDOINDOL Y AMINOINDAZOL CON PROPIEDADES ANTAGONISTAS DE LEUCOTRIENOS. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN HALURO DE ACIDO DE FORMULA RE.X.CO.HAL, EN PRESENCIA DE UN AGENTE DE CONDENSACION, ENTRE 0 Y 60JC, PARA OBTENER UN COMPUESTO DE FORMULA (I); B) OBTENER, POR REACCION CON UNA BASE, EL CATION FISIOLOGICAMENTE ACEPTABLE. SIENDO: ACRA, DI-RADICALES -CRBFRA O -NFCRA; RA, H, CLORO Y OTROS; RB, RC Y RF, H; RE.L, GRUPOS DE FORMULA RE.X.CO.NH-X; X, OXI, TIO Y OTROS; RE, ALQUILO O CICLOALQUILO DE C 3 A 6 Y OTROS; G1.Q.G2, JUNTO CON RD, 2-METOXI-ALFA, Y OTROS; Z, RESIDUO CO.NH.SO2.RG; RG, FENILO.
ES554578A 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol Expired ES8800900A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848426474A GB8426474D0 (en) 1984-10-19 1984-10-19 Heterocyclic amides
GB858507305A GB8507305D0 (en) 1985-03-21 1985-03-21 Amide derivatives
GB858507862A GB8507862D0 (en) 1985-03-26 1985-03-26 Carboxamides
GB858507861A GB8507861D0 (en) 1985-03-26 1985-03-26 Carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
ES8800900A1 true ES8800900A1 (es) 1987-12-01
ES554578A0 ES554578A0 (es) 1987-12-01

Family

ID=27449596

Family Applications (5)

Application Number Title Priority Date Filing Date
ES548011A Expired ES8704458A1 (es) 1984-10-19 1985-10-18 Procedimiento para preparar derivados de almidoindol y amidoindazol.
ES554580A Expired ES8801786A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol
ES554577A Expired ES8800899A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoinzol y amidoinzadol
ES554578A Expired ES8800900A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol
ES554579A Expired ES8802495A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES548011A Expired ES8704458A1 (es) 1984-10-19 1985-10-18 Procedimiento para preparar derivados de almidoindol y amidoindazol.
ES554580A Expired ES8801786A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol
ES554577A Expired ES8800899A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoinzol y amidoinzadol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES554579A Expired ES8802495A1 (es) 1984-10-19 1986-04-30 Procedimiento para preparar derivados de amidoindol y amidoindazol

Country Status (20)

Country Link
US (1) US4997844A (es)
EP (1) EP0179619B1 (es)
JP (1) JPH0745466B2 (es)
KR (1) KR900007419B1 (es)
CN (1) CN85108623A (es)
AT (1) ATE56205T1 (es)
CA (1) CA1273934A (es)
DE (1) DE3579554D1 (es)
DK (1) DK169541B1 (es)
ES (5) ES8704458A1 (es)
FI (1) FI854024L (es)
GB (1) GB8524157D0 (es)
GR (1) GR852519B (es)
HU (1) HU194163B (es)
IE (1) IE58848B1 (es)
IL (1) IL76756A (es)
NO (1) NO854163L (es)
NZ (1) NZ213872A (es)
PT (1) PT81297B (es)
ZW (1) ZW18185A1 (es)

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DK479385D0 (da) 1985-10-18
DE3579554D1 (de) 1990-10-11
ZW18185A1 (en) 1987-05-20
ES8802495A1 (es) 1988-06-16
FI854024A0 (fi) 1985-10-16
ES554577A0 (es) 1987-12-01
ES8704458A1 (es) 1987-04-01
GR852519B (es) 1986-01-24
PT81297A (en) 1985-11-01
ES8801786A1 (es) 1988-02-16
HU194163B (en) 1988-01-28
DK479385A (da) 1986-04-20
PT81297B (pt) 1987-11-30
CN85108623A (zh) 1986-07-30
NZ213872A (en) 1989-11-28
JPS61178963A (ja) 1986-08-11
ES548011A0 (es) 1987-04-01
EP0179619A1 (en) 1986-04-30
GB8524157D0 (en) 1985-11-06
ES554580A0 (es) 1988-02-16
KR900007419B1 (ko) 1990-10-08
ATE56205T1 (de) 1990-09-15
DK169541B1 (da) 1994-11-28
ES8800899A1 (es) 1987-12-01
CA1273934A (en) 1990-09-11
EP0179619B1 (en) 1990-09-05
US4997844A (en) 1991-03-05
NO854163L (no) 1986-04-21
HUT38905A (en) 1986-07-28
IL76756A (en) 1989-05-15
ES554578A0 (es) 1987-12-01
JPH0745466B2 (ja) 1995-05-17
KR860003217A (ko) 1986-05-21
FI854024L (fi) 1986-04-20
ES554579A0 (es) 1988-06-16
IE58848B1 (en) 1993-11-17
IE852589L (en) 1986-04-19

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