DK479385A - Heterocykliske amider - Google Patents
Heterocykliske amider Download PDFInfo
- Publication number
- DK479385A DK479385A DK479385A DK479385A DK479385A DK 479385 A DK479385 A DK 479385A DK 479385 A DK479385 A DK 479385A DK 479385 A DK479385 A DK 479385A DK 479385 A DK479385 A DK 479385A
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- sub
- compounds
- cra
- sup
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848426474A GB8426474D0 (en) | 1984-10-19 | 1984-10-19 | Heterocyclic amides |
GB8426474 | 1984-10-19 | ||
GB858507305A GB8507305D0 (en) | 1985-03-21 | 1985-03-21 | Amide derivatives |
GB8507305 | 1985-03-21 | ||
GB8507861 | 1985-03-26 | ||
GB858507862A GB8507862D0 (en) | 1985-03-26 | 1985-03-26 | Carboxamides |
GB8507862 | 1985-03-26 | ||
GB858507861A GB8507861D0 (en) | 1985-03-26 | 1985-03-26 | Carboxylic acid derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
DK479385D0 DK479385D0 (da) | 1985-10-18 |
DK479385A true DK479385A (da) | 1986-04-20 |
DK169541B1 DK169541B1 (da) | 1994-11-28 |
Family
ID=27449596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK479385A DK169541B1 (da) | 1984-10-19 | 1985-10-18 | Amidisk indol- eller indazolderivat, fremgangsmåde til fremstilling heraf samt farmaceutisk middel indeholdende et sådant |
Country Status (20)
Country | Link |
---|---|
US (1) | US4997844A (da) |
EP (1) | EP0179619B1 (da) |
JP (1) | JPH0745466B2 (da) |
KR (1) | KR900007419B1 (da) |
CN (1) | CN85108623A (da) |
AT (1) | ATE56205T1 (da) |
CA (1) | CA1273934A (da) |
DE (1) | DE3579554D1 (da) |
DK (1) | DK169541B1 (da) |
ES (5) | ES8704458A1 (da) |
FI (1) | FI854024L (da) |
GB (1) | GB8524157D0 (da) |
GR (1) | GR852519B (da) |
HU (1) | HU194163B (da) |
IE (1) | IE58848B1 (da) |
IL (1) | IL76756A (da) |
NO (1) | NO854163L (da) |
NZ (1) | NZ213872A (da) |
PT (1) | PT81297B (da) |
ZW (1) | ZW18185A1 (da) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE862737L (en) * | 1985-10-17 | 1987-04-17 | Staehler Theo | Heterocyclic compounds |
GB8623429D0 (en) * | 1985-10-17 | 1986-11-05 | Ici America Inc | Carboximide derivatives |
GB8609175D0 (en) * | 1986-04-15 | 1986-05-21 | Ici America Inc | Heterocyclic carboxamides |
GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
MY103259A (en) * | 1987-04-15 | 1993-05-29 | Ici America Inc | Aliphatic carboxamides |
GB8807275D0 (en) * | 1988-03-26 | 1988-04-27 | Synphar Lab Inc | Chemical compounds |
AU623897B2 (en) * | 1988-04-13 | 1992-05-28 | Ici Americas Inc. | Indolyl and indazolyl cyclic amides |
US5047402A (en) * | 1988-04-13 | 1991-09-10 | Ici Americas Inc. | Cyclic amides as medicaments |
GB8906032D0 (en) * | 1988-04-14 | 1989-04-26 | Ici America Inc | Hetera-aliphatic carboxamides |
ZA892643B (en) * | 1988-04-14 | 1989-12-27 | Ici America Inc | Carbocyclic compounds |
US5095038A (en) * | 1988-04-14 | 1992-03-10 | Ici Americas Inc. | Carbocyclic compounds useful as leukotriene antagonists |
US5041460A (en) * | 1988-04-14 | 1991-08-20 | Ici Americas Inc. | Heter-aliphatic carboxamides |
AU654140B2 (en) * | 1990-07-31 | 1994-10-27 | Lilly Industries Limited | N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them |
US5281593A (en) * | 1990-07-31 | 1994-01-25 | Lilly Industries Limited | Certain indole derivatives useful as leukotriene antagonists |
GB9020338D0 (en) * | 1990-09-18 | 1990-10-31 | Lilly Industries Ltd | Pharmaceutical compounds |
US5334597A (en) * | 1991-10-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Indole carbamates as leukotriene antagonists |
US5217983A (en) * | 1992-03-27 | 1993-06-08 | Du Pont Merck Pharmaceutical Company | (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories |
US5272169A (en) * | 1992-03-27 | 1993-12-21 | The Dupont Merck Pharmaceutical Company | (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories |
US5439929A (en) * | 1994-03-01 | 1995-08-08 | Pfizer Inc. | Bicyclic carbamates, pharmaceutical compositions and use |
BR9712005A (pt) * | 1996-09-04 | 1999-08-24 | Pfizer | Derivados de indazol e seus usos como inibidores de fosfodiesterase (pde) tipo IV e produ-Æo do fator de necrose de tumor (tnf) |
GB9919411D0 (en) * | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
GB9919413D0 (en) * | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
CA2389360C (en) * | 1999-11-16 | 2008-06-03 | Steffen Breitfelder | Urea derivatives as anti-inflammatory agents |
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
MXPA03005648A (es) * | 2000-12-22 | 2003-10-06 | Astrazeneca Ab | Derivados de carbazol y su uso, como ligandos de receptor del neuropeptido y5. |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
US20050124620A1 (en) * | 2002-04-09 | 2005-06-09 | Martyn Frederickson | Pharmaceutical compounds |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
US7732475B2 (en) | 2005-07-14 | 2010-06-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2007022321A2 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
EP1981851B1 (en) * | 2006-01-31 | 2012-01-25 | Array Biopharma, Inc. | Kinase inhibitors and methods of use thereof |
BRPI0707979A2 (pt) * | 2006-02-20 | 2011-05-17 | Astellas Pharma Cin | derivado de amida ou sal deste |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
CA2869945C (en) | 2006-04-07 | 2018-01-23 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
MX2012012204A (es) | 2010-04-22 | 2012-12-05 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
US8957093B2 (en) | 2011-06-06 | 2015-02-17 | The Scripps Research Institute | N-biphenylmethylindole modulators of PPARG |
US9051265B2 (en) | 2011-06-06 | 2015-06-09 | The Scripps Research Institute | N-benzylindole modulators of PPARG |
ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
KR20140105445A (ko) | 2011-10-31 | 2014-09-01 | 제논 파마슈티칼스 인크. | 비아릴 에테르 술폰아미드 및 치료제로서의 그의 용도 |
US9309227B2 (en) | 2011-11-22 | 2016-04-12 | The Scripps Research Institute | N-biphenylmethylbenzimidazole modulators of PPARG |
EP2844259A4 (en) | 2012-04-30 | 2015-11-11 | Anderson Gaweco | MMR MODULATORS AND USES THEREOF |
EA026393B1 (ru) * | 2012-05-22 | 2017-04-28 | Дженентек, Инк. | N-замещенные бензамиды и их применение в лечении боли |
JP6309519B2 (ja) | 2012-07-06 | 2018-04-11 | ジェネンテック, インコーポレイテッド | N置換ベンズアミド及びその使用方法 |
AR092857A1 (es) | 2012-07-16 | 2015-05-06 | Vertex Pharma | Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas |
EP2968280A4 (en) | 2013-03-14 | 2016-08-10 | Genentech Inc | SUBSTITUTED TRIAZOLOPYRIDINES AND METHOD OF USE THEREOF |
US9493429B2 (en) | 2013-03-15 | 2016-11-15 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
MX2016006936A (es) | 2013-11-27 | 2016-10-05 | Genentech Inc | Benzamidas sustituidas y metodos para usarlas. |
CN110840847B (zh) | 2014-04-15 | 2022-07-29 | 沃泰克斯药物股份有限公司 | 用于治疗囊性纤维化跨膜传导调节因子介导的疾病的药物组合物 |
US10016394B2 (en) | 2014-04-16 | 2018-07-10 | The Scripps Research Institute | PPARG modulators for treatment of osteoporosis |
CN106715418A (zh) | 2014-07-07 | 2017-05-24 | 基因泰克公司 | 治疗化合物及其使用方法 |
CN107835805A (zh) | 2015-05-22 | 2018-03-23 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
WO2017035271A1 (en) | 2015-08-27 | 2017-03-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
JP6987746B2 (ja) | 2015-09-28 | 2022-01-05 | ジェネンテック, インコーポレイテッド | 治療用化合物及びその使用方法 |
EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
PE20190980A1 (es) | 2016-10-17 | 2019-07-09 | Genentech Inc | Compuestos terapeuticos y metodos para utilizarlos |
US10793550B2 (en) | 2017-03-24 | 2020-10-06 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
EP3759098A1 (en) | 2018-02-26 | 2021-01-06 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT234103B (de) * | 1959-09-03 | 1964-06-10 | Merck & Co Inc | Verfahren zur Herstellung von neuen, benzylindolylsubstituierten niedrigen aliphatischen Säuren sowie deren Salzen und Estern |
US3271416A (en) * | 1961-10-24 | 1966-09-06 | Merck & Co Inc | Indolyl aliphatic acids |
FR4035M (da) * | 1964-11-04 | 1966-03-28 | ||
FR5000M (da) * | 1965-06-12 | 1967-04-17 | ||
IT7920398A0 (it) * | 1979-02-21 | 1979-02-21 | Resfar Srl | Derivato ad attivita' analgesica antiinfiammatoria potenziata eprocedimento per la sua preparazione. |
US4363912A (en) * | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
GB2111050B (en) * | 1981-11-19 | 1985-09-11 | Ciba Geigy Ag | N-substituted-2-pyridylindoles |
IE54269B1 (en) * | 1981-12-30 | 1989-08-02 | Ici America Inc | Pharmaceutically active phenylcarboxylic acid derivatives |
DE4138853A1 (de) * | 1991-11-27 | 1993-06-03 | Bayer Ag | 5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11- oxime |
-
1985
- 1985-10-01 GB GB858524157A patent/GB8524157D0/en active Pending
- 1985-10-14 PT PT81297A patent/PT81297B/pt not_active IP Right Cessation
- 1985-10-16 HU HU854007A patent/HU194163B/hu not_active IP Right Cessation
- 1985-10-16 FI FI854024A patent/FI854024L/fi not_active Application Discontinuation
- 1985-10-17 AT AT85307498T patent/ATE56205T1/de not_active IP Right Cessation
- 1985-10-17 DE DE8585307498T patent/DE3579554D1/de not_active Expired - Fee Related
- 1985-10-17 ZW ZW181/85A patent/ZW18185A1/xx unknown
- 1985-10-17 NZ NZ213872A patent/NZ213872A/xx unknown
- 1985-10-17 EP EP85307498A patent/EP0179619B1/en not_active Expired - Lifetime
- 1985-10-18 GR GR852519A patent/GR852519B/el unknown
- 1985-10-18 IL IL76756A patent/IL76756A/xx not_active IP Right Cessation
- 1985-10-18 DK DK479385A patent/DK169541B1/da not_active IP Right Cessation
- 1985-10-18 ES ES548011A patent/ES8704458A1/es not_active Expired
- 1985-10-18 JP JP60231457A patent/JPH0745466B2/ja not_active Expired - Fee Related
- 1985-10-18 CA CA000493372A patent/CA1273934A/en not_active Expired - Lifetime
- 1985-10-18 IE IE258985A patent/IE58848B1/en not_active IP Right Cessation
- 1985-10-18 US US06/788,807 patent/US4997844A/en not_active Expired - Lifetime
- 1985-10-18 NO NO854163A patent/NO854163L/no unknown
- 1985-10-19 KR KR1019850007730A patent/KR900007419B1/ko not_active IP Right Cessation
- 1985-10-19 CN CN198585108623A patent/CN85108623A/zh active Pending
-
1986
- 1986-04-30 ES ES554579A patent/ES8802495A1/es not_active Expired
- 1986-04-30 ES ES554580A patent/ES8801786A1/es not_active Expired
- 1986-04-30 ES ES554578A patent/ES8800900A1/es not_active Expired
- 1986-04-30 ES ES554577A patent/ES8800899A1/es not_active Expired
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