ES2053983T3 - Carboxamidas hetera-alifaticas. - Google Patents

Carboxamidas hetera-alifaticas.

Info

Publication number
ES2053983T3
ES2053983T3 ES89303623T ES89303623T ES2053983T3 ES 2053983 T3 ES2053983 T3 ES 2053983T3 ES 89303623 T ES89303623 T ES 89303623T ES 89303623 T ES89303623 T ES 89303623T ES 2053983 T3 ES2053983 T3 ES 2053983T3
Authority
ES
Spain
Prior art keywords
formula
compounds
hetera
manufacture
aliphatic carboxamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303623T
Other languages
English (en)
Inventor
Victor Giulio Matassa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Application granted granted Critical
Publication of ES2053983T3 publication Critical patent/ES2053983T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Abstract

ESTA INVENCION PROPORCIONA UNA SERIE DE NUEVAS CARBOXAMIDAS HETEROALIFATICAS DE FORMULA I, EN LA QUE EL GRUPO > Z - Y - X < SE SELECCIONA DE > C = CH - N <, > N - CH = C <, > C = N - N < Y > N N = C < Y LOS OTROS RADICALES TIENEN LOS SIGNIFICADOS DEFINIDOS EN LA SIGUIENTE ESPECIFICACION. LOS COMPUESTOS DE FORMULA (I) SON ANTAGONISTAS DE LEUCOTRIENO. LA INVENCION PROPORCIONA TAMBIEN SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS DE FORMULA (I); COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS CITADOS COMPUESTOS O SUS SALES, PARA EMPLEO EN EL TRATAMIENTO, POR EJEMPLO, DE ENFERMEDADES ALERGICAS O INFLAMATORIAS O CONDICIONES DE SHOCK ENDOTOXICO O TRAUMATICO; Y PROCESOS PARA LA FABRICACION DE LOS COMPUESTOS DE FORMULA (I) ASI COMO DE COMPUESTOS INTERMEDIOS PARA EMPLEO EN TAL FABRICACION.
ES89303623T 1988-04-14 1989-04-12 Carboxamidas hetera-alifaticas. Expired - Lifetime ES2053983T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18133488A 1988-04-14 1988-04-14

Publications (1)

Publication Number Publication Date
ES2053983T3 true ES2053983T3 (es) 1994-08-01

Family

ID=22663845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89303623T Expired - Lifetime ES2053983T3 (es) 1988-04-14 1989-04-12 Carboxamidas hetera-alifaticas.

Country Status (23)

Country Link
EP (1) EP0337766B1 (es)
JP (1) JP2740250B2 (es)
KR (1) KR890016016A (es)
CN (1) CN1037895A (es)
AT (1) ATE86612T1 (es)
AU (1) AU622649B2 (es)
CA (1) CA1334197C (es)
DD (1) DD286581A5 (es)
DE (1) DE68905216T2 (es)
DK (1) DK176089A (es)
ES (1) ES2053983T3 (es)
FI (1) FI891764A (es)
GB (1) GB8906032D0 (es)
GR (1) GR3007302T3 (es)
HU (1) HUT54995A (es)
IE (1) IE63209B1 (es)
IL (1) IL89925A0 (es)
MW (1) MW2189A1 (es)
NO (1) NO891501L (es)
NZ (1) NZ228722A (es)
PT (1) PT90269B (es)
ZA (1) ZA892637B (es)
ZM (1) ZM1689A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
EP0539329A1 (de) * 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
ES2072125T3 (es) * 1991-10-25 1995-07-01 Ciba Geigy Ag Procedimiento para la obtencion de indoles substituidos.
US6043264A (en) * 1995-01-06 2000-03-28 Toray Industries, Inc. Benzene-condensed heterocyclic derivatives and their uses
NZ506329A (en) * 1998-02-25 2004-01-30 Inst Genetics Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US6797708B2 (en) 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
TW201309670A (zh) 2011-01-25 2013-03-01 Kissei Pharmaceutical 吲哚衍生物或其藥理學上容許之鹽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides

Also Published As

Publication number Publication date
KR890016016A (ko) 1989-11-28
ZA892637B (en) 1989-12-27
IE63209B1 (en) 1995-04-05
ATE86612T1 (de) 1993-03-15
ZM1689A1 (en) 1990-01-26
MW2189A1 (en) 1989-12-13
EP0337766A1 (en) 1989-10-18
AU3177089A (en) 1989-10-19
CN1037895A (zh) 1989-12-13
NO891501D0 (no) 1989-04-12
DE68905216D1 (de) 1993-04-15
CA1334197C (en) 1995-01-31
JP2740250B2 (ja) 1998-04-15
NO891501L (no) 1989-10-16
AU622649B2 (en) 1992-04-16
JPH01311063A (ja) 1989-12-15
DK176089D0 (da) 1989-04-12
PT90269A (pt) 1989-11-10
FI891764A0 (fi) 1989-04-13
NZ228722A (en) 1991-08-27
IL89925A0 (en) 1989-12-15
IE891188L (en) 1989-10-14
DD286581A5 (de) 1991-01-31
PT90269B (pt) 1994-07-29
FI891764A (fi) 1989-10-15
GB8906032D0 (en) 1989-04-26
GR3007302T3 (es) 1993-07-30
DE68905216T2 (de) 1993-06-17
HUT54995A (en) 1991-04-29
DK176089A (da) 1989-10-15
EP0337766B1 (en) 1993-03-10

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