KR850001882B1 - 3-(4-아미노 에톡시벤조일)벤조 [b] 티오펜유도체의 제조방법 - Google Patents

3-(4-아미노 에톡시벤조일)벤조 [b] 티오펜유도체의 제조방법 Download PDF

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Publication number
KR850001882B1
KR850001882B1 KR8201470A KR820001470A KR850001882B1 KR 850001882 B1 KR850001882 B1 KR 850001882B1 KR 8201470 A KR8201470 A KR 8201470A KR 820001470 A KR820001470 A KR 820001470A KR 850001882 B1 KR850001882 B1 KR 850001882B1
Authority
KR
South Korea
Prior art keywords
acid
compound
benzo
formula
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8201470A
Other languages
English (en)
Korean (ko)
Other versions
KR830010100A (ko
Inventor
데이비스 죤스 챨스
엘리자베쓰 궤텔 메리
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/246,334 external-priority patent/US4358593A/en
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR830010100A publication Critical patent/KR830010100A/ko
Application granted granted Critical
Publication of KR850001882B1 publication Critical patent/KR850001882B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR8201470A 1981-04-03 1982-04-02 3-(4-아미노 에톡시벤조일)벤조 [b] 티오펜유도체의 제조방법 Expired KR850001882B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24633581A 1981-04-03 1981-04-03
US06/246,334 US4358593A (en) 1981-04-03 1981-04-03 Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US246,334 1981-04-03
US33104581A 1981-12-16 1981-12-16
US246,335 1981-12-16
US331,045 1981-12-16

Publications (2)

Publication Number Publication Date
KR830010100A KR830010100A (ko) 1983-12-26
KR850001882B1 true KR850001882B1 (ko) 1985-12-28

Family

ID=27399920

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8201470A Expired KR850001882B1 (ko) 1981-04-03 1982-04-02 3-(4-아미노 에톡시벤조일)벤조 [b] 티오펜유도체의 제조방법

Country Status (17)

Country Link
EP (1) EP0062504B1 (enExample)
KR (1) KR850001882B1 (enExample)
CS (1) CS227348B2 (enExample)
DD (1) DD201793A5 (enExample)
DE (1) DE3268227D1 (enExample)
DK (1) DK151282A (enExample)
EG (1) EG15610A (enExample)
ES (1) ES8307240A1 (enExample)
FI (1) FI821160A7 (enExample)
GB (1) GB2097392B (enExample)
GR (1) GR76468B (enExample)
HU (1) HU191353B (enExample)
IE (1) IE53187B1 (enExample)
IL (1) IL65378A (enExample)
PL (1) PL130867B1 (enExample)
PT (1) PT74692B (enExample)
SU (1) SU1155157A3 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5589482A (en) * 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
CA2249406A1 (en) * 1996-03-19 1997-09-25 Eli Lilly And Company Synthesis of 3-¬4-(2-aminoethoxy)-benzoyl|-2-aryl-6-hydroxy-benzo¬b|thiophenes
PE2699A1 (es) * 1996-09-25 1999-02-04 Lilly Co Eli Procedimiento para la sintesis de benzotiofenos
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
AU7261398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Processes for preparing benzothiophenes
JP2001523253A (ja) * 1997-04-30 2001-11-20 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造のための中間体および方法
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
WO1998048787A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company INTERMEDIATES AND A PROCESS FOR PREPARING BENZO[b]THIOPHENES
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
AU7165398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
EP2322519A1 (en) * 2009-10-23 2011-05-18 Hexal AG A process for preparing benzo[b]thiophene derivatives
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
FR2279395A1 (fr) * 1975-06-02 1976-02-20 Labaz Nouveaux derives de benzthiophene, leurs precedes de preparation ainsi que les compositions pharmaceutiques les contenant
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
IE820786L (en) 1982-10-03
GB2097392A (en) 1982-11-03
DD201793A5 (de) 1983-08-10
DE3268227D1 (en) 1986-02-13
EP0062504B1 (en) 1986-01-02
IL65378A0 (en) 1982-05-31
ES511124A0 (es) 1983-06-16
EP0062504A1 (en) 1982-10-13
FI821160A0 (fi) 1982-04-02
CS227348B2 (en) 1984-04-16
GR76468B (enExample) 1984-08-10
IL65378A (en) 1986-02-28
FI821160L (fi) 1982-10-04
PL130867B1 (en) 1984-09-29
SU1155157A3 (ru) 1985-05-07
HU191353B (en) 1987-02-27
GB2097392B (en) 1985-04-24
IE53187B1 (en) 1988-08-17
EG15610A (en) 1986-06-30
PT74692A (en) 1982-05-01
FI821160A7 (fi) 1982-10-04
DK151282A (da) 1982-10-04
PL235752A1 (enExample) 1982-11-22
ES8307240A1 (es) 1983-06-16
KR830010100A (ko) 1983-12-26
PT74692B (en) 1985-01-08

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