DE3268227D1 - Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes - Google Patents

Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes

Info

Publication number
DE3268227D1
DE3268227D1 DE8282301738T DE3268227T DE3268227D1 DE 3268227 D1 DE3268227 D1 DE 3268227D1 DE 8282301738 T DE8282301738 T DE 8282301738T DE 3268227 T DE3268227 T DE 3268227T DE 3268227 D1 DE3268227 D1 DE 3268227D1
Authority
DE
Germany
Prior art keywords
aminoethoxybenzoyl
thiophenes
benzo
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282301738T
Other languages
English (en)
Inventor
Charles David Jones
Mary Elizabeth Goettel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/246,334 external-priority patent/US4358593A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3268227D1 publication Critical patent/DE3268227D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE8282301738T 1981-04-03 1982-04-01 Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes Expired DE3268227D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24633581A 1981-04-03 1981-04-03
US06/246,334 US4358593A (en) 1981-04-03 1981-04-03 Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US33104581A 1981-12-16 1981-12-16

Publications (1)

Publication Number Publication Date
DE3268227D1 true DE3268227D1 (en) 1986-02-13

Family

ID=27399920

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282301738T Expired DE3268227D1 (en) 1981-04-03 1982-04-01 Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes

Country Status (17)

Country Link
EP (1) EP0062504B1 (de)
KR (1) KR850001882B1 (de)
CS (1) CS227348B2 (de)
DD (1) DD201793A5 (de)
DE (1) DE3268227D1 (de)
DK (1) DK151282A (de)
EG (1) EG15610A (de)
ES (1) ES8307240A1 (de)
FI (1) FI821160L (de)
GB (1) GB2097392B (de)
GR (1) GR76468B (de)
HU (1) HU191353B (de)
IE (1) IE53187B1 (de)
IL (1) IL65378A (de)
PL (1) PL130867B1 (de)
PT (1) PT74692B (de)
SU (1) SU1155157A3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5589482A (en) * 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
AU5258696A (en) * 1996-03-19 1997-10-10 Eli Lilly And Company Synthesis of 3-{4-(2-aminoethoxy)-benzoyl}-2-aryl-6-hydroxy-benzo{b}thiop henes
PE2699A1 (es) * 1996-09-25 1999-02-04 Lilly Co Eli Procedimiento para la sintesis de benzotiofenos
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
BR9809439A (pt) * 1997-04-30 2000-06-13 Lilly Co Eli Processos para preparação de benzotiofenos
WO1998048793A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company INTERMEDIATES AND PROCESSES FOR PREPARING BENZO[b]THIOPHENES
JP2001524114A (ja) * 1997-04-30 2001-11-27 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造における中間体および方法
CA2287918A1 (en) * 1997-04-30 1998-11-05 John Mcneill Mcgill Iii A regioselective alkylation process for preparing substituted benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
EP1832583A1 (de) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Neue Schwefelsäureadditionssalze aus Raloxifen und/oder Solvate daraus sowie pharmazeutische Zusammensetzungen damit
EP2322519A1 (de) * 2009-10-23 2011-05-18 Hexal AG Verfahren zur Herstellung von Benzo[b]thiophenderivaten
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
FR2279395A1 (fr) * 1975-06-02 1976-02-20 Labaz Nouveaux derives de benzthiophene, leurs precedes de preparation ainsi que les compositions pharmaceutiques les contenant
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
PT74692A (en) 1982-05-01
FI821160L (fi) 1982-10-04
DK151282A (da) 1982-10-04
GB2097392A (en) 1982-11-03
DD201793A5 (de) 1983-08-10
KR830010100A (ko) 1983-12-26
IE820786L (en) 1982-10-03
FI821160A0 (fi) 1982-04-02
IE53187B1 (en) 1988-08-17
PL235752A1 (de) 1982-11-22
ES511124A0 (es) 1983-06-16
PT74692B (en) 1985-01-08
ES8307240A1 (es) 1983-06-16
EP0062504A1 (de) 1982-10-13
GR76468B (de) 1984-08-10
SU1155157A3 (ru) 1985-05-07
EG15610A (en) 1986-06-30
PL130867B1 (en) 1984-09-29
KR850001882B1 (ko) 1985-12-28
CS227348B2 (en) 1984-04-16
GB2097392B (en) 1985-04-24
IL65378A0 (en) 1982-05-31
IL65378A (en) 1986-02-28
HU191353B (en) 1987-02-27
EP0062504B1 (de) 1986-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee