KR840007725A - 신규의 아로일이미다졸론 - Google Patents

신규의 아로일이미다졸론 Download PDF

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Publication number
KR840007725A
KR840007725A KR1019840000691A KR840000691A KR840007725A KR 840007725 A KR840007725 A KR 840007725A KR 1019840000691 A KR1019840000691 A KR 1019840000691A KR 840000691 A KR840000691 A KR 840000691A KR 840007725 A KR840007725 A KR 840007725A
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KR
South Korea
Prior art keywords
formula
nitrile
imidazolone
alkoxycarbonyl
cyano
Prior art date
Application number
KR1019840000691A
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English (en)
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KR900001178B1 (ko
Inventor
시. 대그(외 1) 리차드
Original Assignee
게리. 디. 스트리트
메렐 다우 파마슈티칼인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 게리. 디. 스트리트, 메렐 다우 파마슈티칼인코포레이티드 filed Critical 게리. 디. 스트리트
Publication of KR840007725A publication Critical patent/KR840007725A/ko
Application granted granted Critical
Publication of KR900001178B1 publication Critical patent/KR900001178B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음.

Description

신규의 아로일이미다졸론
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식 II의 아미노 디케톤을 일반식 M-N=C=Q의 시안산염 또는 티오시안산염염과 반응시켜서 일반식 III의 화합물을 생성하고, 그렇게 만들어진 1,3-디하이드로-4-(X′-Ar)-5-R-2H-이미다졸론-2-온(III)을 임의로 X가 카보닐일때 (a) 니트릴을 카복실잔기로 가수분해하고; X가 알콕시카보닐일때 (b)(a)에서 형성된 카복실 잔기를 에스테르화하고; X가 카복사미드일때 (c)(b)단계의 생성물을 암모니아 또는 적절한 아민과 함께 가열하여 (b)단계에서 형성된 알콕시 카보닐 잔기를 전환하고 X가 이미다졸-2-일때 (d)(a)단계의 니트릴을 에틸렌 디아민과 축합하고; X가 아미노일때 (e)(a)단계의 니트릴을 이미노 에테르로전환한후 이미노에테르를 암모니아로 처리하는 것을 특징으로 하여 일반식 I 의 학합물 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
    상기식에서 Q 및 T는 각기 산소 또는 2가의 황원자이고, R은 수소, 저급알카노일, 또는 벤조일이며, R1은 수소 또는 저급알킬이고, Ar은 페닐, 피리딜, 피릴 및 티에닐 및 푸라닐이며, X는 시아노, 카복시, 카복사미도, 알콕시카보닐, 아미디노 및 이, 다졸-2-일 그룹의 치환체이고, X′은 시아노이며 M은 알칼리 금속이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000691A 1983-02-15 1984-02-14 아로일이미다졸론 및 이의 제조방법 KR900001178B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46640983A 1983-02-15 1983-02-15
US466409 1983-02-15
US466.409 1983-02-15
US06/562,758 US4552880A (en) 1983-02-15 1983-12-21 Aroylimidazolones
US562,758 1983-12-21

Publications (2)

Publication Number Publication Date
KR840007725A true KR840007725A (ko) 1984-12-10
KR900001178B1 KR900001178B1 (ko) 1990-02-27

Family

ID=27041649

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000691A KR900001178B1 (ko) 1983-02-15 1984-02-14 아로일이미다졸론 및 이의 제조방법

Country Status (15)

Country Link
US (1) US4552880A (ko)
EP (1) EP0118790B1 (ko)
KR (1) KR900001178B1 (ko)
AR (1) AR240811A1 (ko)
AU (1) AU562323B2 (ko)
CA (1) CA1264325A (ko)
DE (1) DE3472556D1 (ko)
DK (1) DK160821C (ko)
ES (1) ES529721A0 (ko)
GR (1) GR81511B (ko)
IE (1) IE57037B1 (ko)
IL (1) IL70943A (ko)
NO (1) NO160513C (ko)
NZ (1) NZ207109A (ko)
PT (1) PT78108B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743612A (en) * 1986-10-17 1988-05-10 Berlex Laboratories, Inc. Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
US20030185882A1 (en) * 2001-11-06 2003-10-02 Vergez Juan A. Pharmaceutical compositions containing oxybutynin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2397250A (en) * 1944-04-29 1946-03-26 Hoffmann La Roche Compounds of the imidazolidone series and process of making them
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
CA1167853A (en) * 1981-05-04 1984-05-22 J. Martin Grisar 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones

Also Published As

Publication number Publication date
IL70943A0 (en) 1984-05-31
NO160513B (no) 1989-01-16
NO160513C (no) 1989-04-26
GR81511B (ko) 1984-12-11
DK160821C (da) 1991-10-14
ES8505351A1 (es) 1985-05-16
EP0118790A1 (en) 1984-09-19
US4552880A (en) 1985-11-12
IE57037B1 (en) 1992-03-25
CA1264325C (en) 1990-01-09
ES529721A0 (es) 1985-05-16
DK65984A (da) 1984-08-16
IL70943A (en) 1988-07-31
EP0118790B1 (en) 1988-07-06
PT78108A (en) 1984-03-01
PT78108B (en) 1986-05-20
IE840335L (en) 1984-08-15
AR240811A1 (es) 1991-02-28
DK160821B (da) 1991-04-22
NO840535L (no) 1984-08-16
NZ207109A (en) 1986-06-11
DK65984D0 (da) 1984-02-14
KR900001178B1 (ko) 1990-02-27
DE3472556D1 (en) 1988-08-11
AU2454184A (en) 1984-08-23
AR240811A2 (es) 1991-02-28
CA1264325A (en) 1990-01-09
AU562323B2 (en) 1987-06-04

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