KR840006631A - 5-(2-알콕시-3-치환된 페닐) 히단토인의 제조방법 - Google Patents

5-(2-알콕시-3-치환된 페닐) 히단토인의 제조방법 Download PDF

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Publication number
KR840006631A
KR840006631A KR1019830005158A KR830005158A KR840006631A KR 840006631 A KR840006631 A KR 840006631A KR 1019830005158 A KR1019830005158 A KR 1019830005158A KR 830005158 A KR830005158 A KR 830005158A KR 840006631 A KR840006631 A KR 840006631A
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KR
South Korea
Prior art keywords
alkoxy
hydantoin
substituted phenyl
preparing
formula
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Application number
KR1019830005158A
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English (en)
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KR860001508B1 (ko
Inventor
시·쉬너 로드니
Original Assignee
폴 에스·밀러
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 폴 에스·밀러, 화이자 인코포레이티드 filed Critical 폴 에스·밀러
Publication of KR840006631A publication Critical patent/KR840006631A/ko
Application granted granted Critical
Publication of KR860001508B1 publication Critical patent/KR860001508B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

5-(2-알콕시-3-치환된 페닐) 히단토인의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(III)의 2-알콕시벤즈아데히드 유도체를 수성알코올 용액내에서, 50℃ 내지 60℃의 온도에서, 2 내지 24시간 동안 탄산암모늄 및 시안화칼륨 또는 시안화나트륨과 반응시키고, 경우에 따라 일반식(I)의 생성화합물을 약제학적으로 무득한 옆으로 전환시킴을 특징으로 하여 다음 일반식(I)의 -5-(2-알콕시-3-치환된 페닐)-히단토인 또는 이의 약제학적으로 무독한 염을 제조하는 방법.
    상기 식에서,
    X는 플루오로, 클로로, (C1-C4)알킬 또는 니트로이고, Y는 플루오로, 클로로 또는 (C1-C4)알킬이고, Z는(C1-C4)알콕시이다.
  2. 제1항에 있어서, 반응 헨즈알데히드 : 시인화칼륨 또는 시안화나트륨 : 탄산암모늄 1:2:4의 몰비로 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005158A 1982-11-01 1983-10-31 5-(2-알콕시-3-치환된 페닐) 히단토인의 제조방법 KR860001508B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/438,200 US4457939A (en) 1982-11-01 1982-11-01 Aldose reductase inhibiting 5-(2-alkoxy-3-substituted phenyl)hydantoins
US438200 1982-11-01
US438,200 1989-11-20

Publications (2)

Publication Number Publication Date
KR840006631A true KR840006631A (ko) 1984-12-01
KR860001508B1 KR860001508B1 (ko) 1986-09-30

Family

ID=23739665

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005158A KR860001508B1 (ko) 1982-11-01 1983-10-31 5-(2-알콕시-3-치환된 페닐) 히단토인의 제조방법

Country Status (13)

Country Link
US (1) US4457939A (ko)
KR (1) KR860001508B1 (ko)
CA (1) CA1195689A (ko)
DK (1) DK157996C (ko)
ES (1) ES526842A0 (ko)
FI (1) FI80682C (ko)
GR (1) GR79639B (ko)
HU (1) HU193187B (ko)
MX (1) MX164727B (ko)
PH (1) PH18396A (ko)
PL (1) PL140522B1 (ko)
PT (1) PT77579A (ko)
YU (1) YU43837B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS227569B1 (en) * 1982-09-24 1984-04-16 Oldrich Kreuz Spring-loading of motorcycle rear wheel
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US7122700B2 (en) * 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5492961A (en) * 1977-12-29 1979-07-23 Ajinomoto Co Inc Production of 5-arylhydantoin
FR2458546A1 (fr) * 1979-06-07 1981-01-02 Hoechst France Procede de fabrication d'aryl-5 hydantoines racemiques et produits nouveaux en resultant

Also Published As

Publication number Publication date
KR860001508B1 (ko) 1986-09-30
FI833994A (fi) 1984-05-02
PH18396A (en) 1985-06-21
YU43837B (en) 1989-12-31
FI833994A0 (fi) 1983-10-31
CA1195689A (en) 1985-10-22
YU216883A (en) 1986-02-28
MX164727B (es) 1992-09-21
HU193187B (en) 1987-08-28
GR79639B (ko) 1984-10-31
DK500083D0 (da) 1983-11-01
ES8504144A1 (es) 1985-04-16
PL140522B1 (en) 1987-05-30
PL244351A1 (en) 1984-09-24
PT77579A (en) 1983-11-01
DK500083A (da) 1984-05-02
DK157996C (da) 1990-08-06
DK157996B (da) 1990-03-12
ES526842A0 (es) 1985-04-16
US4457939A (en) 1984-07-03
FI80682C (fi) 1990-07-10
FI80682B (fi) 1990-03-30

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