ES8504144A1 - Un procedimiento para la preparacion de una 5-(2-alcoxi-fenil 3-sustituido)hidantoina - Google Patents

Un procedimiento para la preparacion de una 5-(2-alcoxi-fenil 3-sustituido)hidantoina

Info

Publication number
ES8504144A1
ES8504144A1 ES526842A ES526842A ES8504144A1 ES 8504144 A1 ES8504144 A1 ES 8504144A1 ES 526842 A ES526842 A ES 526842A ES 526842 A ES526842 A ES 526842A ES 8504144 A1 ES8504144 A1 ES 8504144A1
Authority
ES
Spain
Prior art keywords
hydantoins
alkoxy
substituted phenyl
aldose reductase
reductase inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526842A
Other languages
English (en)
Other versions
ES526842A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES526842A0 publication Critical patent/ES526842A0/es
Publication of ES8504144A1 publication Critical patent/ES8504144A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA 5-(2-ALCOXI-FENIL 3-SUSTITUIDO)HIDANTOINA, DE FORMULA GENERAL (I), EN LA QUE X ES FLUOR, CLORO O NITRO; Y ES FLUOR, CLORO O ALQUILO; Y Z ES ALCOXI, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN DERIVADO DE 2-ALCOXIBENZALDEHIDO, DE FORMULA GENERAL (II), CON CARBONATO AMONICO Y CIANURO POTASICO O SODICO, EN UNA SOLUCION HIDROALCOHOLICA, Y A UNA TEMPERATURA COMPRENDIDA ENTRE 50 Y 60 GRADOS.DE APLICACION COMO AGENTES TERAPEUTICOS PARA EL TRATAMIENTO DE LAS COMPLICACIONES DE LA DIABETES.
ES526842A 1982-11-01 1983-10-28 Un procedimiento para la preparacion de una 5-(2-alcoxi-fenil 3-sustituido)hidantoina Expired ES8504144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/438,200 US4457939A (en) 1982-11-01 1982-11-01 Aldose reductase inhibiting 5-(2-alkoxy-3-substituted phenyl)hydantoins

Publications (2)

Publication Number Publication Date
ES526842A0 ES526842A0 (es) 1985-04-16
ES8504144A1 true ES8504144A1 (es) 1985-04-16

Family

ID=23739665

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526842A Expired ES8504144A1 (es) 1982-11-01 1983-10-28 Un procedimiento para la preparacion de una 5-(2-alcoxi-fenil 3-sustituido)hidantoina

Country Status (13)

Country Link
US (1) US4457939A (es)
KR (1) KR860001508B1 (es)
CA (1) CA1195689A (es)
DK (1) DK157996C (es)
ES (1) ES8504144A1 (es)
FI (1) FI80682C (es)
GR (1) GR79639B (es)
HU (1) HU193187B (es)
MX (1) MX164727B (es)
PH (1) PH18396A (es)
PL (1) PL140522B1 (es)
PT (1) PT77579A (es)
YU (1) YU43837B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS227569B1 (en) * 1982-09-24 1984-04-16 Oldrich Kreuz Spring-loading of motorcycle rear wheel
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US7122700B2 (en) * 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5492961A (en) * 1977-12-29 1979-07-23 Ajinomoto Co Inc Production of 5-arylhydantoin
FR2458546A1 (fr) * 1979-06-07 1981-01-02 Hoechst France Procede de fabrication d'aryl-5 hydantoines racemiques et produits nouveaux en resultant

Also Published As

Publication number Publication date
KR860001508B1 (ko) 1986-09-30
FI80682C (fi) 1990-07-10
YU43837B (en) 1989-12-31
KR840006631A (ko) 1984-12-01
PL244351A1 (en) 1984-09-24
PH18396A (en) 1985-06-21
PT77579A (en) 1983-11-01
PL140522B1 (en) 1987-05-30
DK157996B (da) 1990-03-12
DK157996C (da) 1990-08-06
FI80682B (fi) 1990-03-30
DK500083D0 (da) 1983-11-01
US4457939A (en) 1984-07-03
DK500083A (da) 1984-05-02
MX164727B (es) 1992-09-21
FI833994A0 (fi) 1983-10-31
HU193187B (en) 1987-08-28
ES526842A0 (es) 1985-04-16
FI833994A (fi) 1984-05-02
YU216883A (en) 1986-02-28
CA1195689A (en) 1985-10-22
GR79639B (es) 1984-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203