ES8507119A1 - Procedimiento para la preparacion de un compuesto de 5-(fenil sustituido) hidantoina. - Google Patents

Procedimiento para la preparacion de un compuesto de 5-(fenil sustituido) hidantoina.

Info

Publication number
ES8507119A1
ES8507119A1 ES526841A ES526841A ES8507119A1 ES 8507119 A1 ES8507119 A1 ES 8507119A1 ES 526841 A ES526841 A ES 526841A ES 526841 A ES526841 A ES 526841A ES 8507119 A1 ES8507119 A1 ES 8507119A1
Authority
ES
Spain
Prior art keywords
hydantoins
substituted phenyl
diabetic complications
treating diabetic
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526841A
Other languages
English (en)
Other versions
ES526841A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8507119A1 publication Critical patent/ES8507119A1/es
Publication of ES526841A0 publication Critical patent/ES526841A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS 5-(FENIL SUSTITUIDO) HIDANTOINA, DE FORMULA GENERAL (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN 2-MERCAPTOBENZALDEHIDO, DE FORMULA GENERAL (II) CON CARBONATO AMONICO O CON CIANURO POTASICO O SODICO, EN UNA SOLUCION HIDROALCOHOLICA, A UNA TEMPERATURA COMPRENDIDA ENTRE 50 Y 60 GRADOS.DE APLICACION EN EL TRATAMIENTO DE LAS COMPLICACIONES CRONICAS DE LA DIABETES.
ES526841A 1982-11-01 1983-10-28 Procedimiento para la preparacion de un compuesto de 5-(fenil sustituido) hidantoina. Granted ES526841A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/438,199 US4452806A (en) 1982-11-01 1982-11-01 Treating diabetic complications with 5-(substituted phenyl)hydantoins

Publications (2)

Publication Number Publication Date
ES8507119A1 true ES8507119A1 (es) 1985-05-01
ES526841A0 ES526841A0 (es) 1985-05-01

Family

ID=23739660

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526841A Granted ES526841A0 (es) 1982-11-01 1983-10-28 Procedimiento para la preparacion de un compuesto de 5-(fenil sustituido) hidantoina.

Country Status (13)

Country Link
US (1) US4452806A (es)
JP (1) JPS5998063A (es)
KR (1) KR860001507B1 (es)
CA (1) CA1203241A (es)
DK (1) DK158724C (es)
ES (1) ES526841A0 (es)
FI (1) FI80265C (es)
GR (1) GR79638B (es)
HU (1) HU191887B (es)
PL (1) PL139646B1 (es)
PT (1) PT77578A (es)
YU (1) YU43556B (es)
ZA (1) ZA838092B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002027786A1 (fr) 2000-09-25 2002-04-04 Ibiden Co., Ltd. Element semi-conducteur, procede de fabrication d'un element semi-conducteur, carte a circuit imprime multicouche, et procede de fabrication d'une carte a circuit imprime multicouche
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189587A (en) * 1977-04-05 1980-02-19 Ciba-Geigy Corporation 1,3-Diaminomethyl-hydantoin additives for lubricating oils
FR2458546A1 (fr) * 1979-06-07 1981-01-02 Hoechst France Procede de fabrication d'aryl-5 hydantoines racemiques et produits nouveaux en resultant

Also Published As

Publication number Publication date
YU216783A (en) 1986-02-28
DK158724B (da) 1990-07-09
CA1203241A (en) 1986-04-15
KR840006630A (ko) 1984-12-01
US4452806A (en) 1984-06-05
FI833993A0 (fi) 1983-10-31
KR860001507B1 (ko) 1986-09-30
HU191887B (en) 1987-04-28
FI833993A (fi) 1984-05-02
FI80265C (fi) 1990-05-10
JPS5998063A (ja) 1984-06-06
PL244350A1 (en) 1985-02-13
PT77578A (en) 1983-11-01
GR79638B (es) 1984-10-31
ZA838092B (en) 1985-06-26
JPH0465832B2 (es) 1992-10-21
FI80265B (fi) 1990-01-31
PL139646B1 (en) 1987-02-28
DK499983A (da) 1984-05-02
DK499983D0 (da) 1983-11-01
ES526841A0 (es) 1985-05-01
YU43556B (en) 1989-08-31
DK158724C (da) 1990-11-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203