RO83438B - Procedeu pentru prepararea unor bis-tetrazolmetiltioli - Google Patents

Procedeu pentru prepararea unor bis-tetrazolmetiltioli

Info

Publication number
RO83438B
RO83438B RO105320A RO10532081A RO83438B RO 83438 B RO83438 B RO 83438B RO 105320 A RO105320 A RO 105320A RO 10532081 A RO10532081 A RO 10532081A RO 83438 B RO83438 B RO 83438B
Authority
RO
Romania
Prior art keywords
thiol
methylthyols
tetrasol
general formula
azide
Prior art date
Application number
RO105320A
Other languages
English (en)
Other versions
RO83438A (ro
Inventor
Allen Samuel Katner
Stephen James Bogard
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO83438A publication Critical patent/RO83438A/ro
Publication of RO83438B publication Critical patent/RO83438B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru separarea unor compusi 1H- sau 2H-terazol-5-tiolici cu formula generalaI:(vezi form. in desc.)în care R reprezinta hidrogen sau un radical alchil cu 1.....3 atomi de carbon si R1 reprezinta clor, tiol sau un tiol protejat cu o grupa benzil. Procedeul consta în aceea ca, un compus tetrazolic, cu formula generala II: (vezi form. in desc.) în care R2 reprezintî cian sau N-(alchil cu 1....3 atomi de carbon)-N-clorcarbonil-carbamoil reactioneaza cu o azida aleasa dintre azida tetrametilguanidinei sau cu triazida de aluminiu într-un solvent organic ales dintre dioxan sau tetrahidrofuran la temperatura de reflux.
RO105320A 1980-09-17 1981-09-16 Procedeu pentru prepararea unor bis-tetrazolmetiltioli RO83438B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/187,861 US4338452A (en) 1980-09-17 1980-09-17 1-and 2-(1-Alkyl-1H-tetrazol-5-yl-methyl)-1H-tetrazol-5-thiols and 1-cyanomethyl tetrazole-5-thiol

Publications (2)

Publication Number Publication Date
RO83438A RO83438A (ro) 1984-02-21
RO83438B true RO83438B (ro) 1984-02-28

Family

ID=22690799

Family Applications (1)

Application Number Title Priority Date Filing Date
RO105320A RO83438B (ro) 1980-09-17 1981-09-16 Procedeu pentru prepararea unor bis-tetrazolmetiltioli

Country Status (21)

Country Link
US (1) US4338452A (ro)
EP (1) EP0048167A3 (ro)
JP (1) JPS5781475A (ro)
KR (1) KR830007633A (ro)
AU (1) AU7528381A (ro)
CA (1) CA1170660A (ro)
CS (1) CS228535B2 (ro)
DD (2) DD201588A5 (ro)
DK (1) DK412081A (ro)
ES (2) ES505552A0 (ro)
FI (1) FI812780L (ro)
GB (1) GB2084141B (ro)
GR (1) GR75333B (ro)
HU (1) HU184881B (ro)
IL (1) IL63769A0 (ro)
PH (1) PH17285A (ro)
PL (1) PL132801B1 (ro)
PT (1) PT73682B (ro)
RO (1) RO83438B (ro)
YU (1) YU222981A (ro)
ZA (1) ZA816226B (ro)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404375A (en) * 1980-04-30 1983-09-13 American Cyanamid Company Cephalosporanic acid derivatives
US4404376A (en) * 1980-04-30 1983-09-13 American Cyanamid Company Cephalosporanic acid derivatives
US4404374A (en) * 1980-04-30 1983-09-13 American Cyanamid Company Cephalosporanic acid derivatives
HUT65619A (en) * 1990-07-03 1994-07-28 Yamanouchi Pharma Co Ltd Process for producing bisheterocyclic compounds and pharmaceutical preparations containing them
US6835298B2 (en) * 2002-02-01 2004-12-28 A.T.S. Electro-Lube Holdings, Ltd. Electrolytic generation of nitrogen using azole derivatives
GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2386869A (en) * 1945-10-16 Manufacture of
DE1803605A1 (de) * 1968-10-17 1970-05-21 Agfa Gevaert Ag Photographisches Material
DE2147023C3 (de) * 1971-09-21 1982-04-29 Fujisawa Pharmaceutical Co., Ltd., Osaka Verfahren zur Herstellung von 1H- Tetrazol-Verbindungen
US4110338A (en) * 1973-10-31 1978-08-29 Fujisawa Pharmaceutical Co., Ltd. Product and preparation of 1H-tetrazole-5-thiol derivatives
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4025626A (en) * 1975-12-09 1977-05-24 Smithkline Corporation 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
DE2650231A1 (de) * 1976-11-02 1978-05-11 Hoechst Ag Neue imidazolverbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JPS54160392A (en) * 1978-06-02 1979-12-19 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics

Also Published As

Publication number Publication date
YU222981A (en) 1983-10-31
CS228535B2 (en) 1984-05-14
DK412081A (da) 1982-03-18
AU7528381A (en) 1982-03-25
DD201588A5 (de) 1983-07-27
RO83438A (ro) 1984-02-21
ES8403888A1 (es) 1984-04-01
GR75333B (ro) 1984-07-13
PL132801B1 (en) 1985-04-30
ES520033A0 (es) 1984-04-01
DD201303A5 (de) 1983-07-13
ES8306746A1 (es) 1983-06-01
EP0048167A3 (en) 1982-06-16
JPS5781475A (en) 1982-05-21
PL233054A1 (ro) 1982-08-16
IL63769A0 (en) 1981-12-31
FI812780L (fi) 1982-03-18
ZA816226B (en) 1983-04-27
EP0048167A2 (en) 1982-03-24
US4338452A (en) 1982-07-06
KR830007633A (ko) 1983-11-04
CA1170660A (en) 1984-07-10
PT73682B (en) 1982-11-26
ES505552A0 (es) 1983-06-01
GB2084141B (en) 1985-02-20
PT73682A (en) 1981-10-01
GB2084141A (en) 1982-04-07
HU184881B (en) 1984-10-29
PH17285A (en) 1984-07-06

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