KR840007562A - 치환된 카복실산의 수지산 염의 제조방법 - Google Patents
치환된 카복실산의 수지산 염의 제조방법 Download PDFInfo
- Publication number
- KR840007562A KR840007562A KR1019840000085A KR840000085A KR840007562A KR 840007562 A KR840007562 A KR 840007562A KR 1019840000085 A KR1019840000085 A KR 1019840000085A KR 840000085 A KR840000085 A KR 840000085A KR 840007562 A KR840007562 A KR 840007562A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- copolymer
- salt
- substituted carboxylic
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 발명 화합물과 볼타렌(voltoren)정제 및 서방출 정제의 생물학적 이용률을 비교한 것이다.
Claims (2)
- 다음 구조식(II)의 0-(2,6-디클로로 아닐리노)페닐아세트산 또는 이의 염을 다음 일반식(Ia)의 수지 또는 이의 산과이 염과 반응시킴을 특징으로 하여 다음 일반식(I)의 수지산 염을 제조하는 방법.상기식에서, Am은 양이온 형태인, 스티렌 및 디비닐벤젠의 강염기성 공중합체이고[여기에서, 공중합체는 m+n개의 4급 암모늄 그룹 및 주요 구조 단위로서, 다음 구조식의 그룹을 갖는다.]X는 다음 구조식의 음이온과 다른 산의 음이온이고m 및 n은 분자량이 약 107내지 109인 공중합체의 전체 이온 용량을 나타낸다.
- 제1항에 있어서, 이온교환 수지에 대한 활성 성분의 화학양론비가 1 : 1 내지 1 : 2인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH147/83-1 | 1983-01-12 | ||
CH14783A CH655507B (ko) | 1983-01-12 | 1983-01-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840007562A true KR840007562A (ko) | 1984-12-08 |
KR900006747B1 KR900006747B1 (ko) | 1990-09-20 |
Family
ID=4180317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840000085A KR900006747B1 (ko) | 1983-01-12 | 1984-01-11 | 치환된 카복실산의 수지산염의 제조방법 |
Country Status (41)
Country | Link |
---|---|
US (1) | US4510128A (ko) |
EP (1) | EP0122219B1 (ko) |
JP (1) | JPS59134759A (ko) |
KR (1) | KR900006747B1 (ko) |
AR (1) | AR240310A1 (ko) |
AT (2) | AT391467B (ko) |
AU (1) | AU570230B2 (ko) |
BE (1) | BE898649A (ko) |
CA (1) | CA1218077A (ko) |
CH (1) | CH655507B (ko) |
CS (1) | CS269954B2 (ko) |
DD (1) | DD218373A5 (ko) |
DE (2) | DE3474152D1 (ko) |
DK (1) | DK166683B1 (ko) |
DZ (1) | DZ593A1 (ko) |
EG (1) | EG16562A (ko) |
ES (1) | ES528770A0 (ko) |
FI (1) | FI82682C (ko) |
FR (1) | FR2542735B1 (ko) |
GB (1) | GB2134529B (ko) |
GR (1) | GR79793B (ko) |
HK (1) | HK90390A (ko) |
HU (1) | HU190750B (ko) |
IE (1) | IE56545B1 (ko) |
IL (1) | IL70660A (ko) |
IT (1) | IT1177501B (ko) |
LU (1) | LU85171A1 (ko) |
MA (1) | MA20000A1 (ko) |
MC (1) | MC1564A1 (ko) |
MT (1) | MTP943B (ko) |
NL (1) | NL8400098A (ko) |
NO (1) | NO162862C (ko) |
NZ (1) | NZ206815A (ko) |
OA (1) | OA07628A (ko) |
PH (1) | PH21795A (ko) |
PL (1) | PL142737B1 (ko) |
PT (1) | PT77932B (ko) |
RO (1) | RO88481A (ko) |
SE (1) | SE457959B (ko) |
ZA (1) | ZA84212B (ko) |
ZW (1) | ZW484A1 (ko) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH664085A5 (de) * | 1985-02-08 | 1988-02-15 | Ciba Geigy Ag | Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung. |
ES8604955A1 (es) * | 1985-11-08 | 1986-03-16 | Covex Sa | Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona |
GB8730010D0 (en) * | 1987-12-23 | 1988-02-03 | Smith Kline French Lab | Compounds |
AU608114B2 (en) * | 1987-12-23 | 1991-03-21 | Smith Kline & French Laboratories Limited | Compounds |
US5230885A (en) * | 1987-12-23 | 1993-07-27 | Smith Kline & French Laboratories Limited | Polystyrene anion exchange polymer pharmaceutical composition |
CH675537A5 (ko) * | 1988-03-25 | 1990-10-15 | Ciba Geigy Ag | |
SE509029C2 (sv) * | 1988-08-16 | 1998-11-30 | Ss Pharmaceutical Co | Långtidsverkande diklofenak-natriumpreparat |
US4960799A (en) * | 1988-09-13 | 1990-10-02 | Ciba-Geigy Corporation | Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use |
EP0373103B1 (de) * | 1988-11-10 | 1993-03-31 | Ciba-Geigy Ag | Flüssige orale Formulierung |
CA2002492A1 (en) * | 1988-11-11 | 1990-05-11 | Sandra T. A. Malkowska | Pharmaceutical ion exchange resin composition |
GB8911719D0 (en) * | 1989-05-22 | 1989-07-05 | Smith Kline French Lab | Compounds |
GB8913700D0 (en) * | 1989-06-14 | 1989-08-02 | Smith Kline French Lab | Compounds |
GB8913699D0 (en) * | 1989-06-14 | 1989-08-02 | Smith Kline French Lab | Compounds |
US5079001A (en) * | 1989-11-03 | 1992-01-07 | Ciba-Geigy Corporation | Liquid oral formulation of diclofenac |
GB8928278D0 (en) * | 1989-12-14 | 1990-02-21 | Smith Kline French Lab | Compounds |
SE9004129D0 (sv) * | 1990-12-21 | 1990-12-21 | Pharmacia Lkb Biotech | Anion exchanger |
CA2112751A1 (en) * | 1991-07-03 | 1993-01-21 | Charles J. Ii Betlach | Composition and method for transdermal delivery of diclofenac |
EP1250937B1 (en) * | 2001-04-09 | 2009-05-13 | Rohm And Haas Company | Controlled dissolution of active ingredients |
US20020176842A1 (en) * | 2001-04-09 | 2002-11-28 | Lyn Hughes | Extended release of active ingredients |
US20030180249A1 (en) * | 2002-03-18 | 2003-09-25 | Khanna Satish Chandra | Dosage forms for hygroscopic active ingredients |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
EP1830851A2 (en) * | 2004-12-06 | 2007-09-12 | Themis Laboratories Private Limited | Rapid disintegrating taste masked compositions and a process for its preparations |
RU2435569C2 (ru) | 2006-03-16 | 2011-12-10 | Трис Фарма, Инк. | Композиции с модифицированным высвобождением, содержащие комплексы лекарственное вещество - ионообменная смола |
US7799347B2 (en) * | 2006-09-07 | 2010-09-21 | Chondrex Inc. | Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases |
JP5670336B2 (ja) * | 2008-10-02 | 2015-02-18 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 全身性炎症の治療のためのポリマー吸着剤の投与 |
CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
DK2884961T3 (en) | 2012-08-15 | 2019-04-23 | Tris Pharma Inc | METHYLPHENIDATE TABLE WITH EXTENDED RELEASE |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
CN113395960A (zh) | 2018-11-19 | 2021-09-14 | 爵士制药爱尔兰有限公司 | 抗酒精药物制剂 |
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (15)
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GB857193A (en) * | 1957-03-14 | 1960-12-29 | Clinical Products Ltd | Resin-drug compounds |
GB823000A (en) * | 1957-10-03 | 1959-11-04 | Clinical Products Ltd | Resin-drug compounds |
GB869149A (en) * | 1958-09-16 | 1961-05-31 | Clinical Products Ltd | Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances |
US3316282A (en) * | 1965-02-08 | 1967-04-25 | Squibb & Sons Inc | Anion exchange resin complex of a cycloborate ester of a steroid |
NO125724B (ko) * | 1967-12-20 | 1972-10-23 | Ciba Geigy Ag | |
CH519476A (de) * | 1968-03-30 | 1972-02-29 | Hoechst Ag | Verfahren zur Herstellung von Salzen von Acylamino-alkylbenzolsulfonyl-harnstoffen mit Anionenaustauschern |
US3926864A (en) * | 1971-06-21 | 1975-12-16 | Ionics | Ion exchange membranes having a macroporous surface area |
GB1423694A (en) * | 1973-07-10 | 1976-02-04 | Beecham Group Ltd | Pharmaceutical compositions |
US4058491A (en) * | 1975-02-11 | 1977-11-15 | Plastomedical Sciences, Inc. | Cationic hydrogels based on heterocyclic N-vinyl monomers |
FR2352547A1 (fr) * | 1976-05-25 | 1977-12-23 | Viridis Ets | Nouvelle resine anionique a action hypocholesterolemiante, son procede de preparation et compositions therapeutiques la contenant |
US4217421A (en) * | 1977-06-27 | 1980-08-12 | Rohm And Haas Company | Anion exchange resins prepared from crosslinked polystyrenesulfonylchloride |
US4380590A (en) * | 1978-09-19 | 1983-04-19 | Rohm And Haas Company | Emulsion copolymer cation exchange resins |
IT1106718B (it) * | 1978-12-21 | 1985-11-18 | Alfa Farmaceutici Spa | Composizioni a base di resine anioniche salificate farmacologicamente attive |
US4207399A (en) * | 1979-03-14 | 1980-06-10 | Rohm And Haas Company | Methylquinoline high polymer based on quaternary ammonium polymers |
US4302548A (en) * | 1980-05-22 | 1981-11-24 | Rohm And Haas Company | Production of ion exchange resins, the resins so produced and ion exchange processes using them |
-
1983
- 1983-01-12 CH CH14783A patent/CH655507B/de unknown
-
1984
- 1984-01-02 AT AT0000784A patent/AT391467B/de not_active IP Right Cessation
- 1984-01-05 MT MT943A patent/MTP943B/xx unknown
- 1984-01-06 EP EP84810008A patent/EP0122219B1/de not_active Expired
- 1984-01-06 GB GB08400251A patent/GB2134529B/en not_active Expired
- 1984-01-06 US US06/568,976 patent/US4510128A/en not_active Expired - Lifetime
- 1984-01-06 DE DE8484810008T patent/DE3474152D1/de not_active Expired
- 1984-01-06 AT AT84810008T patent/ATE37378T1/de not_active IP Right Cessation
- 1984-01-06 MA MA20221A patent/MA20000A1/fr unknown
- 1984-01-09 CS CS84178A patent/CS269954B2/cs unknown
- 1984-01-09 FI FI840069A patent/FI82682C/fi not_active IP Right Cessation
- 1984-01-09 DE DE19843400491 patent/DE3400491A1/de active Granted
- 1984-01-09 PT PT77932A patent/PT77932B/pt unknown
- 1984-01-09 RO RO84113260A patent/RO88481A/ro unknown
- 1984-01-10 AR AR295384A patent/AR240310A1/es active
- 1984-01-10 SE SE8400098A patent/SE457959B/sv not_active IP Right Cessation
- 1984-01-10 ZW ZW4/84A patent/ZW484A1/xx unknown
- 1984-01-10 FR FR8400288A patent/FR2542735B1/fr not_active Expired
- 1984-01-10 DZ DZ847047A patent/DZ593A1/fr active
- 1984-01-10 IT IT47527/84A patent/IT1177501B/it active
- 1984-01-10 MC MC841684A patent/MC1564A1/xx unknown
- 1984-01-10 PL PL1984245656A patent/PL142737B1/pl unknown
- 1984-01-10 DD DD84259312A patent/DD218373A5/de not_active IP Right Cessation
- 1984-01-10 CA CA000445018A patent/CA1218077A/en not_active Expired
- 1984-01-10 GR GR73478A patent/GR79793B/el unknown
- 1984-01-10 ES ES528770A patent/ES528770A0/es active Granted
- 1984-01-10 OA OA58200A patent/OA07628A/xx unknown
- 1984-01-11 JP JP59002106A patent/JPS59134759A/ja active Granted
- 1984-01-11 BE BE0/212185A patent/BE898649A/fr not_active IP Right Cessation
- 1984-01-11 IL IL70660A patent/IL70660A/xx not_active IP Right Cessation
- 1984-01-11 DK DK011884A patent/DK166683B1/da not_active IP Right Cessation
- 1984-01-11 ZA ZA84212A patent/ZA84212B/xx unknown
- 1984-01-11 NZ NZ206815A patent/NZ206815A/en unknown
- 1984-01-11 HU HU8473A patent/HU190750B/hu unknown
- 1984-01-11 NO NO840090A patent/NO162862C/no not_active IP Right Cessation
- 1984-01-11 LU LU85171A patent/LU85171A1/de unknown
- 1984-01-11 KR KR1019840000085A patent/KR900006747B1/ko not_active IP Right Cessation
- 1984-01-11 NL NL8400098A patent/NL8400098A/nl not_active Application Discontinuation
- 1984-01-11 AU AU23230/84A patent/AU570230B2/en not_active Expired
- 1984-01-11 IE IE49/84A patent/IE56545B1/en not_active IP Right Cessation
- 1984-01-11 PH PH30094A patent/PH21795A/en unknown
- 1984-01-14 EG EG26/84A patent/EG16562A/xx active
-
1990
- 1990-11-01 HK HK903/90A patent/HK90390A/xx not_active IP Right Cessation
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Payment date: 20020816 Year of fee payment: 13 |
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