ES8604955A1 - Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona - Google Patents

Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona

Info

Publication number
ES8604955A1
ES8604955A1 ES548735A ES548735A ES8604955A1 ES 8604955 A1 ES8604955 A1 ES 8604955A1 ES 548735 A ES548735 A ES 548735A ES 548735 A ES548735 A ES 548735A ES 8604955 A1 ES8604955 A1 ES 8604955A1
Authority
ES
Spain
Prior art keywords
eburnamenin
resinates
preparation
hours
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548735A
Other languages
English (en)
Other versions
ES548735A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES548735A priority Critical patent/ES8604955A1/es
Publication of ES548735A0 publication Critical patent/ES548735A0/es
Publication of ES8604955A1 publication Critical patent/ES8604955A1/es
Priority to GB868626441A priority patent/GB8626441D0/en
Priority to FR8615469A priority patent/FR2589731B1/fr
Priority to CH4407/86A priority patent/CH673281A5/de
Priority to GB8626656A priority patent/GB2184731B/en
Priority to DE19863638064 priority patent/DE3638064A1/de
Priority to JP61266510A priority patent/JPS62142175A/ja
Priority to US07/171,672 priority patent/US4929440A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE RESINATOS DE LA (C) EBURNAMENINA-14-(15H), DE FORMULA (I). CONSISTE EN LA REACCION DE UNA SAL DE ADICION DE LA (C) EBURNAMENINA-14-(15H)-ONA, TAL COMO EL FOSFATO O EL CLORHIDRATO CON UNA RESINA CATIONICA DE CATION TIPO SULFATO POTASICO, CONSTITUIDA POR UN COPOLIMERO DE ESTIRENO QUE CONTIENE UNA PEQUEÑA PROPORCION DE DIVINILBENCENO, EN UN DISOLVENTE POLAR TAL COMO AGUA O UNA MEZCLA DE ETANOL Y AGUA, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 50JC. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE PROBLEMAS DE CIRCULACION CEREBRAL, HIPOXIA CEREBRAL Y SUS SECUELAS.
ES548735A 1985-11-08 1985-11-08 Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona Expired ES8604955A1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES548735A ES8604955A1 (es) 1985-11-08 1985-11-08 Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona
GB868626441A GB8626441D0 (en) 1985-11-08 1986-11-05 Preparation of(-)eburnamenin-14-(15h)-one resinates
FR8615469A FR2589731B1 (fr) 1985-11-08 1986-11-06 Procede de preparation de resinates de la (-)eburnamenine-14-(15h)-one
CH4407/86A CH673281A5 (es) 1985-11-08 1986-11-07
GB8626656A GB2184731B (en) 1985-11-08 1986-11-07 A process for the preparation of (-)eburnamenin-14-(15h)-one resinates
DE19863638064 DE3638064A1 (de) 1985-11-08 1986-11-07 Verfahren zum erzeugen von (-)-eburnamenin-14-(15h)-on-resinaten
JP61266510A JPS62142175A (ja) 1985-11-08 1986-11-08 （―）エブルナメニン―１４―（１５ｈ）―オン樹脂酸塩およびその製造方法
US07/171,672 US4929440A (en) 1985-11-08 1988-03-22 Process for the preparation of (-) eburnamenin-14-(15H)-one resinates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES548735A ES8604955A1 (es) 1985-11-08 1985-11-08 Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona

Publications (2)

Publication Number Publication Date
ES548735A0 ES548735A0 (es) 1986-03-16
ES8604955A1 true ES8604955A1 (es) 1986-03-16

Family

ID=8490144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548735A Expired ES8604955A1 (es) 1985-11-08 1985-11-08 Procedimiento para la preparacion de resinatos de la (-) eburnamenina-14-(15h)-ona

Country Status (7)

Country Link
US (1) US4929440A (es)
JP (1) JPS62142175A (es)
CH (1) CH673281A5 (es)
DE (1) DE3638064A1 (es)
ES (1) ES8604955A1 (es)
FR (1) FR2589731B1 (es)
GB (2) GB8626441D0 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140505A (en) 1995-03-10 2000-10-31 G. D. Searle & Co. Synthesis of benzo fused heterocyclic sulfonyl chlorides
CN103012645B (zh) * 2012-11-27 2015-11-25 安徽皖东化工有限公司 高交换量强酸苯乙烯系阳离子交换树脂的生产方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE550150A (es) * 1955-08-08
US3070503A (en) * 1959-05-22 1962-12-25 Merck & Co Inc Pyrilamine resin absorbate with aspirin and/or ascorbic acid
GB877282A (en) * 1959-06-01 1961-09-13 Pfizer & Co C Therapeutic composition and preparation thereof
US3138525A (en) * 1961-06-16 1964-06-23 Hoffmann La Roche Castor wax-amprotropine-resin compositions
GB1191372A (en) * 1967-05-09 1970-05-13 Pfizer & Co C Process for Novel Cyclic Amidines and their Non-Toxic Acid Addition Salts
GB1218102A (en) * 1968-03-15 1971-01-06 Philips Nv Improvements in medicaments comprising drug/ion-exchange resin compounds
FR2085630A1 (en) * 1970-04-07 1971-12-31 Le Men Georges Vincamone compsn - having vasodilator ganglioplegic and antihistamine activity
FR2253507A1 (en) * 1973-12-11 1975-07-04 Houdet Antoine Vincamine administration using delayed release excipient - allowing prolonged action
US4359555A (en) * 1979-06-29 1982-11-16 Ciba-Geigy Corporation Salts formed from formamidines with polymers containing sulfonic acid groups
JPS5762277A (en) * 1980-06-23 1982-04-15 Ciba Geigy Ag Manufacture of effect-enduring vincamine blend, obtained vincamine blend and medicine
US4369175A (en) * 1981-07-27 1983-01-18 Ciba-Geigy Corporation Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them
CH655507B (es) * 1983-01-12 1986-04-30

Also Published As

Publication number Publication date
GB8626656D0 (en) 1986-12-10
GB8626441D0 (en) 1986-12-03
JPS62142175A (ja) 1987-06-25
FR2589731B1 (fr) 1995-09-29
ES548735A0 (es) 1986-03-16
CH673281A5 (es) 1990-02-28
US4929440A (en) 1990-05-29
DE3638064A1 (de) 1987-05-27
GB2184731B (en) 1990-06-13
FR2589731A1 (fr) 1987-05-15
GB2184731A (en) 1987-07-01
JPH0569837B2 (es) 1993-10-01

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