GB869149A - Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances - Google Patents

Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances

Info

Publication number
GB869149A
GB869149A GB29595/58A GB2959558A GB869149A GB 869149 A GB869149 A GB 869149A GB 29595/58 A GB29595/58 A GB 29595/58A GB 2959558 A GB2959558 A GB 2959558A GB 869149 A GB869149 A GB 869149A
Authority
GB
United Kingdom
Prior art keywords
resins
resin
acid
groups
registered trade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29595/58A
Inventor
William Herbert Linnell
Stephen Paul Rety
Herbert Timmington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Products Ltd
Original Assignee
Clinical Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Products Ltd filed Critical Clinical Products Ltd
Priority to GB29595/58A priority Critical patent/GB869149A/en
Priority to BE582650A priority patent/BE582650A/en
Priority to FR804409A priority patent/FR658M/fr
Publication of GB869149A publication Critical patent/GB869149A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Compounds of ion-exchange resins and ionizable therapeutic agents are prepared by contacting the resin in suitable form with a solution of the therapeutic agent. Suitable resins are copolymers of polystyrene cross-linked with divinyl benzene or aliphatic ester, containing quaternary ammonium or sulphonic acid groups; polystyrene resins containing dibenzylamine groups; and polymerized methacry ic acid resins having a degree of cross-linkage between 1% and 15% and containing carboxyl groups, examples given being those available under the names "Zeokarb" (Registered Trade Mark) 226, 225 and 225H; "Deacidite" (Registered Trade Mark) D, G and FF; "Deminrolit" (Registered Trade Mark). Specified therapeutic agents are b -phenylethylamine derivatives, e.g. ephedrine; dexamphetamine; barbituric acid derivatives, e.g. amylobarbitone; antihistamines; alkaloids e.g. morphine, codeine, hyocy<\>aamine; para-amino-salicylic acid. The resin/drug compounds may be made into pharmaceutical compositions comprising aqueous media, oil in water emulsions, glycerine, cellulose ether, vegetable oil and sucrose esters. Specifications 823,000, 829,245 and 838,952 are referred to.ALSO:Pharmaceutical compositions comprise a carrier liquid substantially free of ions or ionizable material and, dispersed therein, a "resin-drug" compound formed by reacting a cationic or anionic ion-exchange resin with a drug. The carrier liquid may be water, a non-ionizing polyhydric alcohol, e.g. glycerine, or an oil in water emulsion and is preferably an aqueous vehicle or other mixed menstrum in which water is the major component. Non-ionizing sweetening and flavouring agents may be added and the carrier liquid may itself be a sweetening and/or flavouring agent. Non-ionic emulsifying agents, e.g. a sucrose ester, e.g. sucrose distearate, or a soluble cellulose ether may also be present. Specified therapeutically-active substances are b -phenylethylamine derivatives, e.g. ephedrine and dexamphetamine, bartituric acid derivatives, e.g. amylobarbitone, antihistamines, alkaloids, e.g. morphine, codeine, hyoseyamine, hydroxybenzoic acid derivatives, e.g. p-amino-salicylic acid. Specified resins are copolymers of polystyrene with divinyl benzene or aliphatic esters containing quaternary ammonium or sulphonic acid groups; polystyrene resins containing dibenzylamine groups; and polymerized methacrylic acid resins having a degree of crosslinkage between 1 and 15% and containing carboxyl groups, examples being those available under the Registered Trade Marks "Zeokarb" (Nos. 225, 225H and 226), "Deacidite" (D, G and FF), and "Deminrolit" (a mixed anionic and cationic resin). Specifications 823,000, 829,245 and 838,952 are referred to.
GB29595/58A 1958-09-16 1958-09-16 Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances Expired GB869149A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB29595/58A GB869149A (en) 1958-09-16 1958-09-16 Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances
BE582650A BE582650A (en) 1958-09-16 1959-09-14 Medical products and particularly pharmaceutical preparations
FR804409A FR658M (en) 1958-09-16 1960-08-31

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29595/58A GB869149A (en) 1958-09-16 1958-09-16 Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances

Publications (1)

Publication Number Publication Date
GB869149A true GB869149A (en) 1961-05-31

Family

ID=10294021

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29595/58A Expired GB869149A (en) 1958-09-16 1958-09-16 Liquid pharmaceutical compositions comprising compounds of ion exchange resins and therapeutic substances

Country Status (3)

Country Link
BE (1) BE582650A (en)
FR (1) FR658M (en)
GB (1) GB869149A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228152A (en) * 1974-10-15 1980-10-14 Paolo Ferruti Polymers containing prostaglandin radicals, process for their preparation and use thereof
DE2929456A1 (en) 1979-07-20 1981-02-05 Lentia Gmbh COMPOSITION WITH EXTENDED BRONCHOLYTIC AND TOCOLYTIC EFFECTIVENESS, A METHOD FOR THE PRODUCTION THEREOF AND BRONCHOLYTIC AND TOKOLYTICALLY ACTIVE AGENT
GB2134529A (en) * 1983-01-12 1984-08-15 Ciba Geigy Ag Drug-resin complex
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
US5186930A (en) * 1988-11-14 1993-02-16 Schering Corporation Sustained release oral suspensions
US5219563A (en) * 1988-05-11 1993-06-15 Glaxo Group Limited Drug adsorbates
US8232265B2 (en) 2005-10-07 2012-07-31 Board Of Trustees Of The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228152A (en) * 1974-10-15 1980-10-14 Paolo Ferruti Polymers containing prostaglandin radicals, process for their preparation and use thereof
DE2929456A1 (en) 1979-07-20 1981-02-05 Lentia Gmbh COMPOSITION WITH EXTENDED BRONCHOLYTIC AND TOCOLYTIC EFFECTIVENESS, A METHOD FOR THE PRODUCTION THEREOF AND BRONCHOLYTIC AND TOKOLYTICALLY ACTIVE AGENT
US4344933A (en) 1979-07-20 1982-08-17 Chemie Linz Aktiengesellschaft Pharmaceutical composition with prolonged broncholytic and tocolytic activity
GB2134529A (en) * 1983-01-12 1984-08-15 Ciba Geigy Ag Drug-resin complex
US5219563A (en) * 1988-05-11 1993-06-15 Glaxo Group Limited Drug adsorbates
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
US5186930A (en) * 1988-11-14 1993-02-16 Schering Corporation Sustained release oral suspensions
US8232265B2 (en) 2005-10-07 2012-07-31 Board Of Trustees Of The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
US8802596B2 (en) 2005-10-07 2014-08-12 Board Of Trustees Of The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients

Also Published As

Publication number Publication date
FR658M (en) 1961-07-10
BE582650A (en) 1959-12-31

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