KR840007414A - 페넴 에스테르의 제조방법 - Google Patents
페넴 에스테르의 제조방법 Download PDFInfo
- Publication number
- KR840007414A KR840007414A KR1019840000014A KR840000014A KR840007414A KR 840007414 A KR840007414 A KR 840007414A KR 1019840000014 A KR1019840000014 A KR 1019840000014A KR 840000014 A KR840000014 A KR 840000014A KR 840007414 A KR840007414 A KR 840007414A
- Authority
- KR
- South Korea
- Prior art keywords
- phenem
- penem ester
- carbamoyloxymethyl
- acetoxymethyl
- carboxylate
- Prior art date
Links
- -1 penem ester Chemical class 0.000 title claims 8
- 238000004519 manufacturing process Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 claims 1
- 125000005633 phthalidyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 디메틸포름아미드 속의 디메틸아미노피리딘의 존재하에 0° 내지 70℃의 온도에서 일반식(III)의 화합물 또는 이들의 염을 일반식 RX의 화합물과 에스테르화 반응시키는 것을 특징으로 하여, 일반식(II)의 페넴 카복시 에스테르를 제조하는 방법.상기식에서 R은 아세톡시메틸, 피발로일옥시메틸, 메톡시메틸, 메톡시에톡시메틸, 프탈리딜, α-에톡시카보닐옥시에틸, 아세트아미도메틸 또는 벤즈아미도메틸 그룹이고 X는 할로겐 원자이다.
- 제1항에 있어서, 아세톡시메틸-(5R,6S)-2-카바모일옥시메틸-6-[1(R)하이드록시에틸]-2-페넴-3-카복실레이트를 제조하는 방법.
- 제1항에 있어서, 피바로일옥시메틸-(5R,6S)-2-카바모일옥시메틸-6-[1(R)하이드록시에틸]-2-페넴-3-카복실레이트를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8300295 | 1983-01-06 | ||
GB838300295A GB8300295D0 (en) | 1983-01-06 | 1983-01-06 | Penem esters |
GB83-00295 | 1983-01-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840007414A true KR840007414A (ko) | 1984-12-07 |
KR900004418B1 KR900004418B1 (ko) | 1990-06-25 |
Family
ID=10535987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840000014A KR900004418B1 (ko) | 1983-01-06 | 1984-01-05 | 페넴 에스테르의 제조방법 |
Country Status (31)
Country | Link |
---|---|
US (1) | US5051416A (ko) |
JP (1) | JPS59134795A (ko) |
KR (1) | KR900004418B1 (ko) |
AT (1) | AT382622B (ko) |
AU (1) | AU557178B2 (ko) |
BE (1) | BE898603A (ko) |
CA (1) | CA1215042A (ko) |
CH (1) | CH659073A5 (ko) |
CS (2) | CS235996B2 (ko) |
DE (1) | DE3400090A1 (ko) |
DK (1) | DK166387C (ko) |
ES (1) | ES528546A0 (ko) |
FI (1) | FI81103C (ko) |
FR (1) | FR2539130B1 (ko) |
GB (2) | GB8300295D0 (ko) |
GR (1) | GR81730B (ko) |
HK (1) | HK74987A (ko) |
HU (1) | HU191243B (ko) |
IE (1) | IE56903B1 (ko) |
IL (1) | IL70606A (ko) |
IT (1) | IT1209490B (ko) |
NL (1) | NL8400015A (ko) |
NO (1) | NO160446C (ko) |
NZ (1) | NZ206743A (ko) |
PH (1) | PH18881A (ko) |
PT (1) | PT77922B (ko) |
SE (1) | SE458117B (ko) |
SG (1) | SG34387G (ko) |
SU (1) | SU1209031A3 (ko) |
UA (1) | UA6039A1 (ko) |
ZA (1) | ZA8457B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364768A (en) * | 1987-07-07 | 1994-11-15 | Farmitalia Carlo Erba S.R.L. | Process for the preparation of penems |
GB2206578B (en) * | 1987-07-07 | 1991-07-03 | Erba Carlo Spa | Process for the preparation of penems |
EP0937725A3 (en) | 1992-04-28 | 2004-12-01 | Tanabe Seiyaku Co., Ltd. | Method for removing the protecting group for hydroxy group |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7401782A (ko) * | 1973-02-14 | 1974-08-16 | ||
ZA80993B (en) * | 1979-02-24 | 1981-02-25 | Erba Farmitalia | -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof |
AT368506B (de) * | 1979-02-24 | 1982-10-25 | Erba Farmitalia | Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen |
GB2043699B (en) * | 1979-03-03 | 1983-05-11 | Park Chem Co | Cyanide-free carburizing process and composition |
US4482565A (en) * | 1980-02-22 | 1984-11-13 | Farmitalia Carlo Erba S.P.A. | β-Lactam-containing antibacterial agents and β-lactamase inhibitors |
AU556854B2 (en) * | 1981-12-11 | 1986-11-20 | Farmitalia Carlo Erba S.P.A. | Method for preparing penems derivatives |
-
1983
- 1983-01-06 GB GB838300295A patent/GB8300295D0/en active Pending
- 1983-12-29 ES ES528546A patent/ES528546A0/es active Granted
-
1984
- 1984-01-02 FI FI840003A patent/FI81103C/fi not_active IP Right Cessation
- 1984-01-03 NL NL8400015A patent/NL8400015A/nl not_active Application Discontinuation
- 1984-01-03 AU AU23047/84A patent/AU557178B2/en not_active Ceased
- 1984-01-03 IL IL70606A patent/IL70606A/xx not_active IP Right Cessation
- 1984-01-03 FR FR8400040A patent/FR2539130B1/fr not_active Expired
- 1984-01-03 AT AT0001584A patent/AT382622B/de not_active IP Right Cessation
- 1984-01-03 CS CS8480A patent/CS235996B2/cs unknown
- 1984-01-03 IT IT8419007A patent/IT1209490B/it active
- 1984-01-03 GB GB08400043A patent/GB2133010B/en not_active Expired
- 1984-01-03 GR GR73420A patent/GR81730B/el unknown
- 1984-01-03 DE DE19843400090 patent/DE3400090A1/de not_active Ceased
- 1984-01-04 PT PT77922A patent/PT77922B/pt not_active IP Right Cessation
- 1984-01-04 SE SE8400040A patent/SE458117B/sv not_active IP Right Cessation
- 1984-01-04 CA CA000444654A patent/CA1215042A/en not_active Expired
- 1984-01-04 BE BE0/212151A patent/BE898603A/fr not_active IP Right Cessation
- 1984-01-04 ZA ZA8457A patent/ZA8457B/xx unknown
- 1984-01-04 IE IE6/84A patent/IE56903B1/en not_active IP Right Cessation
- 1984-01-04 PH PH30064A patent/PH18881A/en unknown
- 1984-01-05 KR KR1019840000014A patent/KR900004418B1/ko not_active IP Right Cessation
- 1984-01-05 HU HU8437A patent/HU191243B/hu not_active IP Right Cessation
- 1984-01-05 DK DK005284A patent/DK166387C/da active
- 1984-01-05 JP JP59000110A patent/JPS59134795A/ja active Granted
- 1984-01-05 NZ NZ206743A patent/NZ206743A/en unknown
- 1984-01-05 UA UA3688716A patent/UA6039A1/uk unknown
- 1984-01-05 CH CH42/84A patent/CH659073A5/de not_active IP Right Cessation
- 1984-01-05 NO NO840035A patent/NO160446C/no unknown
- 1984-01-05 SU SU843688716A patent/SU1209031A3/ru active
-
1987
- 1987-04-14 SG SG34387A patent/SG34387G/en unknown
- 1987-10-15 HK HK749/87A patent/HK74987A/xx not_active IP Right Cessation
-
1989
- 1989-04-03 US US07/331,853 patent/US5051416A/en not_active Expired - Fee Related
-
1991
- 1991-12-20 CS CS914150A patent/CS415091A3/cs unknown
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A201 | Request for examination | ||
N231 | Notification of change of applicant | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19950617 Year of fee payment: 6 |
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LAPS | Lapse due to unpaid annual fee |