KR840002146B1 - 빈카 다이머의 제조방법 - Google Patents

빈카 다이머의 제조방법 Download PDF

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Publication number
KR840002146B1
KR840002146B1 KR1019810000914A KR810000914A KR840002146B1 KR 840002146 B1 KR840002146 B1 KR 840002146B1 KR 1019810000914 A KR1019810000914 A KR 1019810000914A KR 810000914 A KR810000914 A KR 810000914A KR 840002146 B1 KR840002146 B1 KR 840002146B1
Authority
KR
South Korea
Prior art keywords
vlb
chloroethyl
carboxamide
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810000914A
Other languages
English (en)
Korean (ko)
Other versions
KR830005248A (ko
Inventor
코린 밀러 진
에드워드 구토우스카 제랄드
Original Assignee
일라이 릴리 앤드 캄파니
아더 알. 웨일
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 일라이 릴리 앤드 캄파니, 아더 알. 웨일 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR830005248A publication Critical patent/KR830005248A/ko
Application granted granted Critical
Publication of KR840002146B1 publication Critical patent/KR840002146B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019810000914A 1980-03-20 1981-03-19 빈카 다이머의 제조방법 Expired KR840002146B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/132,246 US4357334A (en) 1980-03-20 1980-03-20 Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US132246 1980-03-20

Publications (2)

Publication Number Publication Date
KR830005248A KR830005248A (ko) 1983-08-03
KR840002146B1 true KR840002146B1 (ko) 1984-11-23

Family

ID=22453135

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000914A Expired KR840002146B1 (ko) 1980-03-20 1981-03-19 빈카 다이머의 제조방법

Country Status (28)

Country Link
US (1) US4357334A (OSRAM)
EP (1) EP0036762B1 (OSRAM)
JP (1) JPS56145293A (OSRAM)
KR (1) KR840002146B1 (OSRAM)
AR (1) AR228863A1 (OSRAM)
AT (1) ATE9761T1 (OSRAM)
AU (1) AU539564B2 (OSRAM)
BG (1) BG36200A3 (OSRAM)
CA (1) CA1159055A (OSRAM)
DD (1) DD157558A5 (OSRAM)
DE (1) DE3166544D1 (OSRAM)
DK (1) DK124281A (OSRAM)
EG (1) EG15247A (OSRAM)
ES (2) ES500536A0 (OSRAM)
FI (1) FI810856A7 (OSRAM)
GB (1) GB2072184B (OSRAM)
GR (1) GR73870B (OSRAM)
HU (1) HU185247B (OSRAM)
IE (1) IE51034B1 (OSRAM)
IL (1) IL62378A (OSRAM)
NZ (1) NZ196511A (OSRAM)
PH (1) PH16213A (OSRAM)
PL (1) PL230226A1 (OSRAM)
PT (1) PT72695B (OSRAM)
RO (2) RO82171A (OSRAM)
SU (2) SU1017172A3 (OSRAM)
YU (1) YU66281A (OSRAM)
ZA (1) ZA811733B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124502B1 (fr) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Nouveaux conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques contenant ces conjugués
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (OSRAM) 1976-09-08 1982-07-07 Lilly Co Eli
US4160767A (en) * 1976-12-06 1979-07-10 Eli Lilly And Company Vinca alkaloid intermediates
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4191688A (en) * 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
HU185247B (en) 1984-12-28
IL62378A0 (en) 1981-05-20
GB2072184B (en) 1984-01-11
EG15247A (en) 1986-03-31
ES8206538A1 (es) 1982-08-16
NZ196511A (en) 1983-09-30
BG36200A3 (bg) 1984-09-14
PT72695B (en) 1982-03-24
SU1017172A3 (ru) 1983-05-07
PL230226A1 (OSRAM) 1982-03-15
EP0036762B1 (en) 1984-10-10
ZA811733B (en) 1982-10-27
JPS56145293A (en) 1981-11-11
RO85813B (ro) 1984-11-30
IE810609L (en) 1981-09-20
YU66281A (en) 1983-10-31
RO82171A (ro) 1983-07-07
GR73870B (OSRAM) 1984-05-09
ES8302009A1 (es) 1982-12-16
DD157558A5 (de) 1982-11-17
SU1200851A3 (ru) 1985-12-23
PH16213A (en) 1983-08-05
DK124281A (da) 1981-09-21
ATE9761T1 (de) 1984-10-15
DE3166544D1 (en) 1984-11-15
RO82171B (ro) 1983-06-30
KR830005248A (ko) 1983-08-03
RO85813A (ro) 1984-11-25
GB2072184A (en) 1981-09-30
ES500536A0 (es) 1982-08-16
US4357334A (en) 1982-11-02
ES509581A0 (es) 1982-12-16
CA1159055A (en) 1983-12-20
AR228863A1 (es) 1983-04-29
IE51034B1 (en) 1986-09-17
PT72695A (en) 1981-04-01
AU6858181A (en) 1981-09-24
EP0036762A2 (en) 1981-09-30
FI810856L (fi) 1981-09-21
FI810856A7 (fi) 1981-09-21
IL62378A (en) 1984-03-30
AU539564B2 (en) 1984-10-04
EP0036762A3 (en) 1981-10-07

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19810319

PG1501 Laying open of application
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19840426

Patent event code: PE09021S01D

PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19841026

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19850205