ES8206538A1 - Un procedimiento para preparar un dimero de vinca - Google Patents
Un procedimiento para preparar un dimero de vincaInfo
- Publication number
- ES8206538A1 ES8206538A1 ES500536A ES500536A ES8206538A1 ES 8206538 A1 ES8206538 A1 ES 8206538A1 ES 500536 A ES500536 A ES 500536A ES 500536 A ES500536 A ES 500536A ES 8206538 A1 ES8206538 A1 ES 8206538A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical formulation
- vinca dimer
- vinca
- dimer
- vlb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN DIMERO DE LA VINCA,ASI COMO DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE R1 ES EL RADICAL HIDROXI O ACETOXI. CONSISTE EN LA REACCION DE HIDROLISIS DE LA 3"-(2-CLOROETIL)-3-ESPIRO-5"-OXADOLIDIN-2", 4"-DIONA DE VLB (O 4-DESACETIL VLB). LA REACCION SE LLEVA A CABO EN MEDIO ACUOSO ALCALINO, A UNA TEMPERATURA ENTRE 25 Y 50C. EL COMPUESTO OBTENIDO SE SEPARA EN FORMA DE BASE LIBRE O DE UNA SAL DE ACIDO Y SE PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FAMACOLOGICAS COMO AGENTES ANTITUMORALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/132,246 US4357334A (en) | 1980-03-20 | 1980-03-20 | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8206538A1 true ES8206538A1 (es) | 1982-08-16 |
ES500536A0 ES500536A0 (es) | 1982-08-16 |
Family
ID=22453135
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500536A Granted ES500536A0 (es) | 1980-03-20 | 1981-03-18 | Un procedimiento para preparar un dimero de vinca |
ES509581A Granted ES509581A0 (es) | 1980-03-20 | 1982-02-12 | Un procedimiento para la preparacion de un dimero de la vinca. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509581A Granted ES509581A0 (es) | 1980-03-20 | 1982-02-12 | Un procedimiento para la preparacion de un dimero de la vinca. |
Country Status (28)
Country | Link |
---|---|
US (1) | US4357334A (es) |
EP (1) | EP0036762B1 (es) |
JP (1) | JPS56145293A (es) |
KR (1) | KR840002146B1 (es) |
AR (1) | AR228863A1 (es) |
AT (1) | ATE9761T1 (es) |
AU (1) | AU539564B2 (es) |
BG (1) | BG36200A3 (es) |
CA (1) | CA1159055A (es) |
DD (1) | DD157558A5 (es) |
DE (1) | DE3166544D1 (es) |
DK (1) | DK124281A (es) |
EG (1) | EG15247A (es) |
ES (2) | ES500536A0 (es) |
FI (1) | FI810856L (es) |
GB (1) | GB2072184B (es) |
GR (1) | GR73870B (es) |
HU (1) | HU185247B (es) |
IE (1) | IE51034B1 (es) |
IL (1) | IL62378A (es) |
NZ (1) | NZ196511A (es) |
PH (1) | PH16213A (es) |
PL (1) | PL230226A1 (es) |
PT (1) | PT72695B (es) |
RO (2) | RO85813B (es) |
SU (2) | SU1017172A3 (es) |
YU (1) | YU66281A (es) |
ZA (1) | ZA811733B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR81790B (es) * | 1983-04-29 | 1984-12-12 | Omnichem Sa | |
HUT76925A (hu) * | 1995-04-04 | 1998-01-28 | MTA Enzimológiai Intézet | Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204004A1 (es) | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
IL48685A (en) | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
GR69783B (es) | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
US4096148A (en) * | 1976-12-06 | 1978-06-20 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
USRE30561E (en) | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
US4160767A (en) * | 1976-12-06 | 1979-07-10 | Eli Lilly And Company | Vinca alkaloid intermediates |
US4191688A (en) * | 1977-08-08 | 1980-03-04 | Eli Lilly And Company | Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine |
US4203898A (en) * | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
-
1980
- 1980-03-20 US US06/132,246 patent/US4357334A/en not_active Expired - Lifetime
-
1981
- 1981-03-16 CA CA000373113A patent/CA1159055A/en not_active Expired
- 1981-03-16 ZA ZA00811733A patent/ZA811733B/xx unknown
- 1981-03-16 GR GR64408A patent/GR73870B/el unknown
- 1981-03-16 YU YU00662/81A patent/YU66281A/xx unknown
- 1981-03-16 NZ NZ196511A patent/NZ196511A/xx unknown
- 1981-03-16 IL IL62378A patent/IL62378A/xx unknown
- 1981-03-16 PH PH25360A patent/PH16213A/en unknown
- 1981-03-17 AR AR284619A patent/AR228863A1/es active
- 1981-03-18 ES ES500536A patent/ES500536A0/es active Granted
- 1981-03-18 EG EG81148A patent/EG15247A/xx active
- 1981-03-19 DE DE8181301186T patent/DE3166544D1/de not_active Expired
- 1981-03-19 SU SU813259901A patent/SU1017172A3/ru active
- 1981-03-19 FI FI810856A patent/FI810856L/fi not_active Application Discontinuation
- 1981-03-19 PT PT72695A patent/PT72695B/pt unknown
- 1981-03-19 KR KR1019810000914A patent/KR840002146B1/ko active IP Right Grant
- 1981-03-19 AT AT81301186T patent/ATE9761T1/de not_active IP Right Cessation
- 1981-03-19 IE IE609/81A patent/IE51034B1/en unknown
- 1981-03-19 PL PL23022681A patent/PL230226A1/xx unknown
- 1981-03-19 RO RO110924A patent/RO85813B/ro unknown
- 1981-03-19 RO RO81103759A patent/RO82171A/ro unknown
- 1981-03-19 EP EP81301186A patent/EP0036762B1/en not_active Expired
- 1981-03-19 GB GB8108644A patent/GB2072184B/en not_active Expired
- 1981-03-19 HU HU81707A patent/HU185247B/hu unknown
- 1981-03-19 DK DK124281A patent/DK124281A/da not_active IP Right Cessation
- 1981-03-20 BG BG8151306A patent/BG36200A3/xx unknown
- 1981-03-20 AU AU68581/81A patent/AU539564B2/en not_active Ceased
- 1981-03-20 JP JP4162781A patent/JPS56145293A/ja active Pending
- 1981-03-20 DD DD81228492A patent/DD157558A5/de unknown
-
1982
- 1982-02-12 ES ES509581A patent/ES509581A0/es active Granted
- 1982-05-04 SU SU823430670A patent/SU1200851A3/ru active
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