KR830003492A - 클라불란산 및 약제학적으로 가능한 근의 염이나 에스테르를 제조하는 방법 - Google Patents

클라불란산 및 약제학적으로 가능한 근의 염이나 에스테르를 제조하는 방법 Download PDF

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Publication number
KR830003492A
KR830003492A KR1019800003345A KR800003345A KR830003492A KR 830003492 A KR830003492 A KR 830003492A KR 1019800003345 A KR1019800003345 A KR 1019800003345A KR 800003345 A KR800003345 A KR 800003345A KR 830003492 A KR830003492 A KR 830003492A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
clavulanic acid
esters
methods
acceptable salts
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Application number
KR1019800003345A
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English (en)
Other versions
KR860000343B1 (ko
Inventor
앨런 쿠크 마이클
데이빗드 커즌스 아란
베넷트 윌킨스 로버어트
Original Assignee
로늘드 스미자아
비이참 그루우프 리미팃드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 로늘드 스미자아, 비이참 그루우프 리미팃드 filed Critical 로늘드 스미자아
Publication of KR830003492A publication Critical patent/KR830003492A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

클라불란산 및 약제학적으로 가능한 그의 염이나 에스테르를 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 클라불란산의 3급 부틸아민염을 클라불란산이나 약제학적으로 가능한 그의 염이나 에스테르로 전환시켜 클라불란산이나 약제학적으로 가능한 그의 염이나 에스테르를 제조하는 방법.
    * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003345A 1979-08-24 1980-08-25 클라불란산 및 약제학적으로 허용되는 그의 염을 제조하는 방법 KR860000343B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7929544 1979-08-24
GB29544 1979-08-24

Publications (2)

Publication Number Publication Date
KR830003492A true KR830003492A (ko) 1983-06-20
KR860000343B1 KR860000343B1 (ko) 1986-04-12

Family

ID=10507413

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003345A KR860000343B1 (ko) 1979-08-24 1980-08-25 클라불란산 및 약제학적으로 허용되는 그의 염을 제조하는 방법

Country Status (20)

Country Link
US (1) US4647659A (ko)
EP (1) EP0026044B1 (ko)
JP (2) JPS5634685A (ko)
KR (1) KR860000343B1 (ko)
AU (1) AU535198B2 (ko)
CA (1) CA1157862A (ko)
DE (1) DE3063683D1 (ko)
DK (1) DK156069C (ko)
ES (1) ES8106157A1 (ko)
FI (1) FI67222C (ko)
GR (1) GR69870B (ko)
HK (1) HK1086A (ko)
HU (1) HU185619B (ko)
IE (1) IE50047B1 (ko)
IL (1) IL60885A (ko)
MY (1) MY8500999A (ko)
NO (1) NO165241C (ko)
NZ (1) NZ194703A (ko)
PL (1) PL139811B1 (ko)
ZA (1) ZA805206B (ko)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
GR1000035B (el) * 1987-01-29 1990-03-12 Beecham Group Plc Κλαβουλανικο καλιο.
ES2010143A6 (es) † 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
JPH0457085U (ko) * 1990-09-14 1992-05-15
JPH0569557U (ja) * 1992-02-26 1993-09-21 東京電機工業株式會社 固体蓄熱装置
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
AT1447U1 (de) * 1992-06-11 1997-05-26 Smithkline Beecham Plc Neue salze von clavulansäure
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
AT475U1 (de) * 1992-06-11 1995-11-27 Smithkline Beecham Plc Verfahren zur herstellung von clavulansaeure
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
AT1446U1 (de) * 1992-10-31 1997-05-26 Smithkline Beecham Plc Verfahren zur herstellung und/oder reinigung von clavulansäure
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
HUT69372A (en) * 1993-03-26 1995-09-28 Gist Brocades Nv Diamine salts of clarulanic acid, pharmaceutical compositions containing the same and process for their production
DE4318916A1 (de) * 1993-06-07 1994-12-08 Bayer Ag Cyclobutylazole
ATE198892T1 (de) 1993-11-17 2001-02-15 Biochemie Gmbh Trennung von cephalosporinisomeren
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
AU691727B2 (en) * 1995-02-25 1998-05-21 Spurcourt Limited Clavulanic acid salts
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
JPH09152148A (ja) * 1995-09-29 1997-06-10 Tokyo Denki Kogyo Kk 蓄熱式空調装置
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AU5409799A (en) * 1998-07-03 2000-01-24 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
WO2000018947A1 (en) * 1998-09-29 2000-04-06 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
ES2177391B1 (es) * 2000-04-19 2004-08-16 Felipe Lopez Oliva Muñoz Protesis de disco cervical.
CA2408853C (en) * 2000-05-13 2012-01-10 Smithkline Beecham P.L.C. Process
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1572912A (en) * 1977-01-19 1980-08-06 Beecham Group Ltd Clavulanic acid esters
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate

Also Published As

Publication number Publication date
DK156069C (da) 1989-12-04
JPH02167286A (ja) 1990-06-27
ES494431A0 (es) 1981-07-16
IE801777L (en) 1981-02-24
CA1157862A (en) 1983-11-29
EP0026044B1 (en) 1983-06-08
PL226397A1 (ko) 1981-05-22
NO165241B (no) 1990-10-08
IE50047B1 (en) 1986-02-05
PL139811B1 (en) 1987-02-28
NO802498L (no) 1981-02-25
US4647659A (en) 1987-03-03
FI802590A (fi) 1981-02-25
JPS5634685A (en) 1981-04-06
DK156069B (da) 1989-06-19
IL60885A (en) 1983-11-30
DE3063683D1 (en) 1983-07-14
HU185619B (en) 1985-03-28
NO165241C (no) 1991-01-16
JPH0415234B2 (ko) 1992-03-17
ZA805206B (en) 1981-08-26
JPH0234954B2 (ko) 1990-08-07
DK363080A (da) 1981-02-25
HK1086A (en) 1986-01-10
IL60885A0 (en) 1980-10-26
KR860000343B1 (ko) 1986-04-12
FI67222B (fi) 1984-10-31
AU535198B2 (en) 1984-03-08
GR69870B (ko) 1982-07-20
NZ194703A (en) 1983-09-02
ES8106157A1 (es) 1981-07-16
FI67222C (fi) 1985-02-11
MY8500999A (en) 1985-12-31
EP0026044A1 (en) 1981-04-01
AU6163280A (en) 1981-04-09

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