ES444539A1 - Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol. - Google Patents

Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol.

Info

Publication number
ES444539A1
ES444539A1 ES444539A ES444539A ES444539A1 ES 444539 A1 ES444539 A1 ES 444539A1 ES 444539 A ES444539 A ES 444539A ES 444539 A ES444539 A ES 444539A ES 444539 A1 ES444539 A1 ES 444539A1
Authority
ES
Spain
Prior art keywords
trimethoxy
tetrahydro
pyridyl
phenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES444539A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES444539A priority Critical patent/ES444539A1/es
Priority to AR265998A priority patent/AR210629A1/es
Priority to BE173891A priority patent/BE850150A/xx
Priority to US05/757,175 priority patent/US4111945A/en
Priority to DE19772700638 priority patent/DE2700638A1/de
Priority to CH22677A priority patent/CH597186A5/xx
Priority to FR7700455A priority patent/FR2338932A1/fr
Priority to SE7700216A priority patent/SE7700216L/xx
Priority to PT66061A priority patent/PT66061B/pt
Priority to NZ183070A priority patent/NZ183070A/xx
Priority to NL7700312A priority patent/NL7700312A/xx
Priority to CA269,833A priority patent/CA1047499A/en
Priority to AT21577A priority patent/AT348527B/de
Priority to JP407677A priority patent/JPS52105180A/ja
Priority to GB2336/77A priority patent/GB1516962A/en
Priority to SU772440271A priority patent/SU667134A3/ru
Priority to AU21588/77A priority patent/AU506428B2/en
Publication of ES444539A1 publication Critical patent/ES444539A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE 3,4,5-TRIMETOXIFENIL-(1,4-DIMETIL-1,2,3,6-TETRAHIDRO-2-PIRIDIL)-CARBINOL DE FORMULA: **FORMULA** SE HACE REACCIONAR EL 3,4,5-TRIMETOXIFENIL-4-(4-METIL-2-PIRIDIL)-CARBINOL CON IODURO DE METILO CON LO CUAL SE OBTIENE EL IODURO DE 3,4,5-TRIMETOXIFENIL-(1,4-DIMETIL-2-PIRIDINIL)-CARBINOL, EL CUAL SE SOMETE A UNA REACCION DE REDUCCION PARA OBTENER EL PRODUCTO ANTES FORMULADO. EL PRODUCTO OBTENIDO PRESENTA ACTIVIDAD ANALGESICA.
ES444539A 1976-01-22 1976-01-22 Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol. Expired ES444539A1 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ES444539A ES444539A1 (es) 1976-01-22 1976-01-22 Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol.
AR265998A AR210629A1 (es) 1976-01-22 1976-12-27 Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-di-metil-1,2,3,6-tetrahidro-2-piridil)-carbinol particularmente util como agente activo analgesico
BE173891A BE850150A (fr) 1976-01-22 1977-01-06 Phenyl-tetrahydropyridyl-carbinols et medicaments qui en contiennent
US05/757,175 US4111945A (en) 1976-01-22 1977-01-06 Process for the preparation of 3,4,5-trimethoxy-phenyl-(1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridyl)-carbinol
DE19772700638 DE2700638A1 (de) 1976-01-22 1977-01-08 Verfahren zur herstellung von 3,4,5-trimethoxyphenyl-(1,4-dimethyl- 1,2,3,6-tetrahydro-2-pyridyl)-carbinol
CH22677A CH597186A5 (es) 1976-01-22 1977-01-10
FR7700455A FR2338932A1 (fr) 1976-01-22 1977-01-10 Phenyl- tetrahydropyridyl-carbinols et medicaments qui en contiennent
SE7700216A SE7700216L (sv) 1976-01-22 1977-01-11 Sett att framstella ett analgetikum
PT66061A PT66061B (fr) 1976-01-22 1977-01-12 Procede de preparation de 3,4,5-trimethoxyphenyl-(1,4-dimethyl-1,2,3,6-tetra-hydro-2-pyridil)-carbinol
NZ183070A NZ183070A (en) 1976-01-22 1977-01-13 3,4,5-trimethoxyphenyl-(1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridyl)-carbinol and analgesic compositions
NL7700312A NL7700312A (nl) 1976-01-22 1977-01-13 Werkwijze voor het bereiden van 3,4,5-trimethoxy- fenyl-(1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridyl)- -carbinol.
CA269,833A CA1047499A (en) 1976-01-22 1977-01-17 Process for the preparation of 3,4,5-trimethoxy-phenyl-(1,4-dimethyl-1,2,-3,6- tetrahydro-2-pyridyl)-carbinol
AT21577A AT348527B (de) 1976-01-22 1977-01-17 Verfahren zur herstellung des neuen 3,4,5- trimethoxyphenyl- (1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridyl)- carbinols
JP407677A JPS52105180A (en) 1976-01-22 1977-01-19 Carbinol derivative and its acid adduct salt
GB2336/77A GB1516962A (en) 1976-01-22 1977-01-20 Tetrahydropyridine-derived carbinols
SU772440271A SU667134A3 (ru) 1976-01-22 1977-01-21 Способ получени хлоргидрата 3,4,5-триметоксифенил-(1,4-диметил-1,2,3,6-тетрагидро-2-пиридил)-карбинола
AU21588/77A AU506428B2 (en) 1976-01-22 1977-01-24 3, 4, 5 trimethoxy phenyl (1, 4-dimethyl- 1, 2, 3, 6-terahydro-2-pyridyl) carbinol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES444539A ES444539A1 (es) 1976-01-22 1976-01-22 Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol.

Publications (1)

Publication Number Publication Date
ES444539A1 true ES444539A1 (es) 1977-06-01

Family

ID=8470783

Family Applications (1)

Application Number Title Priority Date Filing Date
ES444539A Expired ES444539A1 (es) 1976-01-22 1976-01-22 Procedimiento para la obtencion de 3,4,5-trimetoxifenil-(1,4-dimetil-1,2,3,6-tetrahidro-2-piridil)-carbinol.

Country Status (17)

Country Link
US (1) US4111945A (es)
JP (1) JPS52105180A (es)
AR (1) AR210629A1 (es)
AT (1) AT348527B (es)
AU (1) AU506428B2 (es)
BE (1) BE850150A (es)
CA (1) CA1047499A (es)
CH (1) CH597186A5 (es)
DE (1) DE2700638A1 (es)
ES (1) ES444539A1 (es)
FR (1) FR2338932A1 (es)
GB (1) GB1516962A (es)
NL (1) NL7700312A (es)
NZ (1) NZ183070A (es)
PT (1) PT66061B (es)
SE (1) SE7700216L (es)
SU (1) SU667134A3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637716A (en) * 1993-07-30 1997-06-10 Eisai Co., Ltd. Processes for the preparation of hydroquinone and benzoquinone derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3093650A (en) * 1963-06-11 Alternative synthesis of
US3426030A (en) * 1966-10-21 1969-02-04 Mcneilab Inc 4-tetrahydropyridylacrylic acid derivatives
US3839345A (en) * 1968-03-07 1974-10-01 H Pars Esters of tetrahydropyridines
ES425972A1 (es) * 1974-05-04 1976-09-16 Made Labor Sa Un procedimiento para la obtencion de la 1,3,4-trimetil-2- (3,4,5-trimetoxibencil)-1,2,5,6-tetrahidropiridina.

Also Published As

Publication number Publication date
AT348527B (de) 1979-02-26
AU2158877A (en) 1978-08-03
BE850150A (fr) 1977-07-06
AR210629A1 (es) 1977-08-31
ATA21577A (de) 1978-07-15
SE7700216L (sv) 1977-07-23
AU506428B2 (en) 1980-01-03
JPS52105180A (en) 1977-09-03
CH597186A5 (es) 1978-03-31
US4111945A (en) 1978-09-05
SU667134A3 (ru) 1979-06-05
PT66061A (fr) 1977-02-01
GB1516962A (en) 1978-07-05
NZ183070A (en) 1979-06-08
FR2338932B1 (es) 1978-11-17
PT66061B (fr) 1978-06-23
NL7700312A (nl) 1977-07-26
FR2338932A1 (fr) 1977-08-19
DE2700638A1 (de) 1977-07-28
CA1047499A (en) 1979-01-30

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