KR830000606B1 - 세팔로스포린 항생제의 제조방법 - Google Patents

세팔로스포린 항생제의 제조방법 Download PDF

Info

Publication number
KR830000606B1
KR830000606B1 KR7901689A KR790001689A KR830000606B1 KR 830000606 B1 KR830000606 B1 KR 830000606B1 KR 7901689 A KR7901689 A KR 7901689A KR 790001689 A KR790001689 A KR 790001689A KR 830000606 B1 KR830000606 B1 KR 830000606B1
Authority
KR
South Korea
Prior art keywords
acid
compound
group
compounds
formula
Prior art date
Application number
KR7901689A
Other languages
English (en)
Korean (ko)
Inventor
오칼라간 신티아힐다
죠지 허버트 리버모어 데비드
뉴얼 크리스토퍼얼
Original Assignee
헤롤드 월터 마틴
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 헤롤드 월터 마틴, 글락소 그룹 리미티드 filed Critical 헤롤드 월터 마틴
Priority to KR1019830000281A priority Critical patent/KR830000835B1/ko
Application granted granted Critical
Publication of KR830000606B1 publication Critical patent/KR830000606B1/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR7901689A 1978-05-26 1979-05-25 세팔로스포린 항생제의 제조방법 KR830000606B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830000281A KR830000835B1 (ko) 1978-05-26 1983-01-25 세팔로스포린 항생제의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2291178 1978-05-26
GB22911/78 1978-05-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019830000281A Division KR830000835B1 (ko) 1978-05-26 1983-01-25 세팔로스포린 항생제의 제조방법

Publications (1)

Publication Number Publication Date
KR830000606B1 true KR830000606B1 (ko) 1983-03-17

Family

ID=10187065

Family Applications (2)

Application Number Title Priority Date Filing Date
KR7901689A KR830000606B1 (ko) 1978-05-26 1979-05-25 세팔로스포린 항생제의 제조방법
KR1019830000281A KR830000835B1 (ko) 1978-05-26 1983-01-25 세팔로스포린 항생제의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019830000281A KR830000835B1 (ko) 1978-05-26 1983-01-25 세팔로스포린 항생제의 제조방법

Country Status (10)

Country Link
JP (6) JPS54154786A (ja)
KR (2) KR830000606B1 (ja)
AT (2) AT369380B (ja)
BE (1) BE876538A (ja)
CA (1) CA1132538A (ja)
CY (1) CY1168A (ja)
GB (2) GB2025398B (ja)
HU (1) HU184631B (ja)
IT (1) IT1210588B (ja)
ZA (2) ZA807323B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145686B (it) * 1979-05-25 1986-11-05 Glaxo Group Ltd Intermedi per la preparazione di antibiotici cefalosporinici e procedimento per prepararli
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS5756486A (en) * 1980-08-11 1982-04-05 Fujisawa Pharmaceut Co Ltd Novel cephem compound or its salt, their preparation and prophylactic or remedy for microbism containing the same as active ingredient
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
JPS5910593A (ja) 1982-06-28 1984-01-20 Bristol Mayers Kenkyusho Kk セフアロスポリン誘導体
DE3239365A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
DE3381408D1 (de) * 1982-12-27 1990-05-10 Lilly Co Eli Zwischenverbindungen fuer die herstellung von ceftazidin und verfahren zu ihrer herstellung.
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
GB8410991D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410993D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410992D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
KR0164458B1 (ko) * 1995-04-04 1999-01-15 김은영 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
US5872249A (en) * 1995-09-01 1999-02-16 Korea Institute Of Science And Technology 3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法

Also Published As

Publication number Publication date
JPH0257073B2 (ja) 1990-12-03
JPS6127990A (ja) 1986-02-07
JPS6322093A (ja) 1988-01-29
IT8149648A0 (it) 1981-11-06
JPS625916B2 (ja) 1987-02-07
KR830000835B1 (ko) 1983-04-20
GB2025398A (en) 1980-01-23
JPH0257069B2 (ja) 1990-12-03
GB2058791B (en) 1982-11-24
ZA792581B (en) 1981-01-28
IT1210588B (it) 1989-09-14
AT369381B (de) 1982-12-27
ZA807323B (en) 1981-02-25
JPS6354689B2 (ja) 1988-10-28
AT369380B (de) 1982-12-27
CY1168A (en) 1983-06-10
JPS6127989A (ja) 1986-02-07
JPS55149289A (en) 1980-11-20
JPH0257554B2 (ja) 1990-12-05
ATA173881A (de) 1982-05-15
HU184631B (en) 1984-09-28
JPS54154786A (en) 1979-12-06
BE876538A (fr) 1979-11-26
GB2058791A (en) 1981-04-15
GB2025398B (en) 1982-08-11
ATA173981A (de) 1982-05-15
CA1132538A (en) 1982-09-28
JPS6127921A (ja) 1986-02-07

Similar Documents

Publication Publication Date Title
KR830000606B1 (ko) 세팔로스포린 항생제의 제조방법
FI67555C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbart (6 7r)-7-((z)-2-(2-aminotiazol-4-yl)-2-(2-karboxiprop-2-oxi imno)-acetamido)-3-(1-pyridiniummetyl)-cef-3-em-4-karboxyla t
FI67384B (fi) Foerfarande foer framstaellning av farmaceutiskt anvaendbara 7-(2-(2-imino-4-tiazolin-4-yl)-2-hydroxiiminoacetamido)-3-cefem-4-karboxylsyraderivat
US4464368A (en) Cephalosporin antibiotics
CA1130280A (en) Cephalosporin compounds
US4315005A (en) Cephalosporin antibiotics
KR830001130B1 (ko) 세팔로스포린 항생제의 제조방법
KR830001891B1 (ko) 세팔로스포린 항생물질의 제조방법
IE49275B1 (en) Cephalosporin antibiotics
US4560683A (en) Cephalosporin antibiotics
US4200746A (en) Cephalosporins
KR830001593B1 (ko) 세팔로스포린 항생제의 제조방법
SE438859B (sv) 7-acylamido-3-karbamoyloximetyl-3-cefem-4-karboxylsyraderivat och forfarande for framstellning derav
CA1129408A (en) Cephalosporin antibiotics
GB2132193A (en) Cephalosporin antibiotics
CA1122973A (en) Cephalosporin antibiotics
US4963542A (en) Cephalosporin derivatives
EP0095329A2 (en) Cephalosporin antibiotics
GB2183630A (en) Cephalosporin antibiotics
GB2183629A (en) Cephalosporin antibiotics

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
G160 Decision to publish patent application
O132 Decision on opposition [patent]
GRNT Written decision to grant
J206 Request for trial to confirm the scope of a patent right
J121 Written withdrawal of request for trial
FPAY Annual fee payment

Payment date: 19940317

Year of fee payment: 12

EXPY Expiration of term