KR20240132100A - 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도 - Google Patents

키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도 Download PDF

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Publication number
KR20240132100A
KR20240132100A KR1020247027659A KR20247027659A KR20240132100A KR 20240132100 A KR20240132100 A KR 20240132100A KR 1020247027659 A KR1020247027659 A KR 1020247027659A KR 20247027659 A KR20247027659 A KR 20247027659A KR 20240132100 A KR20240132100 A KR 20240132100A
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cell
car
cells
macrophages
tumor
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Korean (ko)
Inventor
자르 길
마이클 클리친스키
칼 에이치. 준
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더 트러스티스 오브 더 유니버시티 오브 펜실베니아
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Publication of KR20240132100A publication Critical patent/KR20240132100A/ko
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KR1020247027659A 2015-07-28 2016-07-28 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도 Pending KR20240132100A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562197675P 2015-07-28 2015-07-28
US62/197,675 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof
KR1020187005871A KR102697827B1 (ko) 2015-07-28 2016-07-28 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도

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KR1020187005871A Active KR102697827B1 (ko) 2015-07-28 2016-07-28 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도

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Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
JP7032304B2 (ja) * 2015-07-28 2022-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア キメラ抗原受容体を発現する改変された単球/マクロファージおよびその使用
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
SG10201913151TA (en) 2015-09-09 2020-03-30 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Genetic engineering of macrophages for immunotherapy
EP3334764A2 (en) * 2015-10-13 2018-06-20 Brigham Young University Macrophage chimeric antigen receptor (moto-car) in imunotherapy
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
WO2018064076A1 (en) 2016-09-27 2018-04-05 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
CN107286246B (zh) * 2016-12-28 2019-12-17 时力生物科技(北京)有限公司 治疗脑胶质瘤的嵌合抗原受体修饰的树突状细胞及其制备方法
MX2019010171A (es) 2017-02-27 2019-10-15 Juno Therapeutics Inc Composiciones, articulos de fabricacion y metodos relacionados con la dosificacion en la terapia celular.
EP3624834A1 (en) * 2017-05-17 2020-03-25 Thunder Biotech Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
US10415017B2 (en) 2017-05-17 2019-09-17 Thunder Biotech, Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
IL327498A (en) * 2017-06-02 2026-05-01 Juno Therapeutics Inc Articles of manufacture and methods for treatment using adoptive cell therapy
DK3688032T3 (da) 2017-09-26 2025-12-15 Cero Therapeutics Holdings Inc Kimære engulfment-receptormolekyler og anvendelsesfremgangsmåder
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
JP7357626B2 (ja) 2017-11-01 2023-10-06 ジュノー セラピューティクス インコーポレイテッド 操作された細胞の治療用組成物を生成するためのプロセス
BR112020011223A2 (pt) 2017-12-08 2020-11-17 Juno Therapeutics Inc marcadores fenotípicos para terapia celular e mé-todos relacionados
CN111542338B (zh) 2017-12-27 2024-06-18 武田药品工业株式会社 含核酸脂质纳米粒子及其用途
CN108047332B (zh) * 2018-01-15 2021-08-24 阿思科力(苏州)生物科技有限公司 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用
CA3089991A1 (en) * 2018-02-02 2019-08-08 The Trustees Of The University Of Pennsylvania Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates
CN112004829A (zh) * 2018-03-12 2020-11-27 南克维斯特公司 Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途
WO2019183266A1 (en) 2018-03-21 2019-09-26 ALX Oncology Inc. Antibodies against signal-regulatory protein alpha and methods of use
WO2019191332A1 (en) * 2018-03-28 2019-10-03 Cero Therapeutics, Inc. Chimeric engulfment receptors and uses thereof for neurodegenerative diseases
RU2020135107A (ru) 2018-03-28 2022-04-29 Серо Терапьютикс, Инк. Клеточные иммунотерапевтические композиции и их применения
MX2020010235A (es) * 2018-03-28 2020-10-28 Cero Therapeutics Inc Vectores de expresion para receptores de engullimiento quimerico, celulas hospederas geneticamente modificadas y usos de los mismos.
US12291557B2 (en) 2018-03-28 2025-05-06 Cero Therapeutics Holdings, Inc. Chimeric TIM4 receptors and uses thereof
GB201807945D0 (en) 2018-05-16 2018-06-27 Ospedale San Raffaele Srl Vector production
CN110615843B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含第三信号受体的嵌合抗原受体及其应用
CN112567026B (zh) 2018-07-19 2024-08-23 昂科霍斯特公司 Il-31改善用于癌症的基于巨噬细胞的过继性细胞疗法的功效
EP3844500A4 (en) * 2018-08-27 2022-05-11 NantBio, Inc. RP182 COMPOSITIONS AND METHODS
EA202190624A1 (ru) 2018-08-31 2021-06-09 Нойл-Иммьюн Байотек, Инк. Car-экспрессирующие т-клетки и car-экспрессирующий вектор
WO2020047371A1 (en) * 2018-08-31 2020-03-05 The Trustees Of The University Of Pennsylvania Activation of antigen presenting cells and methods for using the same
CN111004781A (zh) * 2018-10-08 2020-04-14 南加利福尼亚大学 长期扩增粒细胞-巨噬细胞祖细胞的方法及其应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN109266618B (zh) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 能够靶向肿瘤细胞的巨噬细胞及其制备方法
EP3876977A1 (en) 2018-11-06 2021-09-15 The Regents Of The University Of California Chimeric antigen receptors for phagocytosis
CN113226340A (zh) 2018-11-26 2021-08-06 恩卡尔塔公司 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
WO2020160217A1 (en) * 2019-02-01 2020-08-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Microenvironment sensors to regulate engineered gene expression
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
US12018061B2 (en) * 2019-03-08 2024-06-25 St Phi Therapeutics Co., Ltd. Chimeric endocytic receptors and method of use thereof
AU2020266595A1 (en) * 2019-04-30 2021-11-25 Create Medicines, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
US11026973B2 (en) 2019-04-30 2021-06-08 Myeloid Therapeutics, Inc. Engineered phagocytic receptor compositions and methods of use thereof
US20220162644A1 (en) * 2019-05-29 2022-05-26 Orbis Health Solutions, Llc Delivery vectors and particles for expressing chimeric receptors and methods of using the same
CN120485288A (zh) 2019-06-26 2025-08-15 武田药品工业株式会社 转染方法
PL3999080T3 (pl) * 2019-07-19 2024-02-05 Institut Gustave-Roussy Monocyty wykazujące ekspresję p21 do terapii komórki nowotworowej
CN118165120A (zh) * 2019-07-22 2024-06-11 南京助天中科科技发展有限公司 一种嵌合抗原受体及其应用
WO2021019706A1 (ja) 2019-07-31 2021-02-04 国立大学法人信州大学 Car発現免疫細胞を含む細胞集団の製造方法
WO2021046243A2 (en) 2019-09-03 2021-03-11 Myeloid Therapeutics, Inc. Methods and compositions for genomic integration
WO2021055973A2 (en) * 2019-09-20 2021-03-25 Navi Bio-Therapeutics, Inc. Personalized cancer immunotherapy
KR102498546B1 (ko) * 2019-09-27 2023-02-09 한국생명공학연구원 항체를 분비하는 대식세포의 제조방법 및 이를 이용한 항암치료 기술
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
MX2022007107A (es) * 2019-12-11 2022-11-14 Myeloid Therapeutics Inc Composiciones celulares terapeuticas y metodos de preparacion y usos de las mismas.
CN110954701B (zh) * 2019-12-18 2023-07-21 重庆医科大学 一种肝纤维化或肝硬化的诊断试剂盒
CN113106067B (zh) * 2020-01-10 2024-06-21 南京大学 一种嵌合抗原受体-单核/巨噬细胞(car-m)的构建及其应用
WO2021142835A1 (zh) * 2020-01-19 2021-07-22 北京卡替医疗技术有限公司 一种提升免疫细胞功能的增强受体
CN113248620A (zh) * 2020-02-13 2021-08-13 四川大学 一种嵌合抗原受体的共刺激信号结构域及其应用
WO2021180215A1 (en) * 2020-03-12 2021-09-16 Nanjing Legend Biotech Co., Ltd. Glypican-2-binding moieties, chimeric antigen receptors and uses thereof
CN115884778A (zh) * 2020-05-05 2023-03-31 Aro生物疗法公司 与前列腺特异性膜抗原结合的纤连蛋白iii型结构域和包含该结构域的细胞
EP3915576A1 (en) * 2020-05-28 2021-12-01 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Chimeric antigen receptors specific for p95her2 and uses thereof
EP4161536A4 (en) * 2020-06-04 2024-08-14 Carisma Therapeutics Inc. Novel constructs for chimeric antigen receptors
CN111840324B (zh) * 2020-06-16 2023-05-12 上海市第一人民医院 应用于骨肉瘤细胞成像或治疗的Au DENPs-巨噬细胞复合物
MX2022015888A (es) * 2020-06-26 2023-03-28 Carisma Therapeutics Inc Transfección de ácido ribonucleico mensajero (arnm) de células inmunitarias.
CN111925448B (zh) * 2020-08-03 2022-06-21 山东大学 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用
JP7868033B2 (ja) 2020-08-14 2026-06-01 セロ・セラピューティクス・ホールディングス・インコーポレイテッド キメラtim受容体およびその使用
GB202014920D0 (en) 2020-09-22 2020-11-04 Unikum Therapeutics Aps Methods for treating cancer and autoimmune and inflammatory diseases
EP4217377A4 (en) * 2020-09-23 2024-11-27 Myeloid Therapeutics, Inc. Improved methods and compositions for expression of nucleic acids in cells
EP4240367A4 (en) * 2020-11-04 2024-10-16 Myeloid Therapeutics, Inc. MODIFIED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
CN112830974B (zh) * 2021-01-08 2022-07-26 深圳市珈钰生物科技有限公司 一种嵌合抗原受体、载体、人树突状细胞、细胞系、实体肿瘤治疗药物及制备方法和应用
WO2022153698A1 (ja) * 2021-01-15 2022-07-21 国立大学法人東海国立大学機構 キメラ標的因子受容体
US20240066059A1 (en) * 2021-03-03 2024-02-29 Seoul National University R&Db Foundation Method for producing chimeric antigen receptor-macrophages and use of same cells
KR20240013094A (ko) 2021-03-17 2024-01-30 마이얼로이드 테라퓨틱스, 인크. 조작된 키메라 융합 단백질 조성물 및 그의 사용 방법
KR20220131801A (ko) 2021-03-22 2022-09-29 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022203226A1 (ko) * 2021-03-22 2022-09-29 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022203227A1 (ko) * 2021-03-23 2022-09-29 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
KR20220132401A (ko) 2021-03-23 2022-09-30 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
KR20220136876A (ko) 2021-04-01 2022-10-11 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022211376A1 (ko) * 2021-04-01 2022-10-06 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022215920A1 (ko) * 2021-04-06 2022-10-13 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
CN114934071B (zh) * 2021-04-30 2023-10-17 四川大学华西医院 一种表达免疫调节因子的car载体及其应用
WO2022241029A1 (en) 2021-05-11 2022-11-17 Myeloid Therapeutics, Inc. Methods and compositions for genomic integration
CA3215633A1 (en) * 2021-05-19 2022-11-24 University Of Southern California Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy
AU2022280016A1 (en) * 2021-05-24 2024-01-04 Create Medicines, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
CN113321743B (zh) * 2021-07-02 2022-10-21 海南精准医疗科技有限公司 一种靶向赖氨酰氧化酶1的嵌合抗原受体及其用途
KR20230089462A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
KR20230089464A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用
CN114657143B (zh) * 2022-03-11 2022-10-25 西安电子科技大学 一种肿瘤微环境调控型car-单核/巨噬细胞及其制备方法和应用
EP4504245A1 (en) 2022-04-07 2025-02-12 Institut Curie Myeloid cells modified by chimeric antigen receptor and uses thereof for anti-cancer therapy
US20250222106A1 (en) 2022-04-07 2025-07-10 Institut Curie Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy
JP2025513245A (ja) * 2022-04-18 2025-04-24 ウィスコンシン アラムニ リサーチ ファンデーション Car-m細胞、car-nk細胞、car-eos細胞、及びcar-n細胞を使用した併用免疫療法
CN114949190B (zh) * 2022-04-29 2024-04-30 苏州易慕峰生物科技有限公司 抗原递呈细胞及car-t细胞联合在抗肿瘤中的应用
GB202208605D0 (en) 2022-06-13 2022-07-27 Unikum Therapeutics Aps Engineered immune cells
JPWO2024034656A1 (cg-RX-API-DMAC7.html) * 2022-08-09 2024-02-15
JP2025542299A (ja) * 2022-12-21 2025-12-25 ウニヴェルズィテート チューリッヒ マクロファージを極性化するための方法
CN115957335B (zh) * 2023-01-03 2024-05-28 华中科技大学同济医学院附属协和医院 基于嵌合抗原受体修饰的单核细胞外囊泡类似物、制备方法及应用
CN116218786B (zh) * 2023-03-09 2024-01-23 山东大学齐鲁医院 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用
CN116380580A (zh) * 2023-03-15 2023-07-04 中国人民解放军空军军医大学 一种血浆检测前处理方法
TW202449142A (zh) 2023-04-07 2024-12-16 日商武田藥品工業股份有限公司 接合複合物
EP4483866A1 (en) 2023-06-28 2025-01-01 Makrolife Biotech GmbH Pharmaceutical compositions for the treatment or prevention of cancer
CN120005830A (zh) * 2023-11-06 2025-05-16 复星凯瑞(上海)生物科技有限公司 一种分泌cd47-pd-l1的基因修饰的免疫细胞的制备及应用
GB202318553D0 (en) 2023-12-05 2024-01-17 Unikum Therapeutics Aps Engineered plasmacytoid dendritic cells
CN118059217B (zh) * 2023-12-20 2025-02-28 西安电子科技大学 一种表观遗传药物联合过继单核/巨噬细胞免疫治疗在制备肿瘤疾病生物药品中的应用
CN118206664A (zh) * 2024-02-04 2024-06-18 中国科学院杭州医学研究所 原位生成多功能嵌合抗原受体巨噬细胞的方法及其在免疫治疗中的应用
CN118685362A (zh) * 2024-05-15 2024-09-24 西安电子科技大学 一种癌环境响应型的过继单核或巨噬细胞免疫治疗生物制品及其在抗肿瘤中的应用
CN121488047A (zh) * 2024-07-15 2026-02-06 南京元迈细胞生物科技有限公司 腺病毒载体及其应用
WO2026082877A1 (en) 2024-10-16 2026-04-23 Institut Gustave Roussy P21 overexpressing immune cells with an antigen-binding domain at their surface
CN121538180A (zh) * 2025-11-28 2026-02-17 中国医学科学院肿瘤医院 经修饰的单核细胞、其制备方法和应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334764A (en) 1966-10-25 1967-08-08 John P Fouser Infant nurser
US20040053837A1 (en) 1998-09-30 2004-03-18 Ludwig Institute For Cancer Research Composition and method for modulating vasculogenesis or angiogenesis
US7446179B2 (en) 2000-11-07 2008-11-04 City Of Hope CD19-specific chimeric T cell receptor
AU2003219805B2 (en) * 2002-02-15 2009-06-04 Eisai Inc. Electroporation methods for introducing bioactive agents into cells
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
CN101072879B (zh) * 2004-10-13 2011-05-11 克鲁塞尔荷兰公司 改良的腺病毒载体及其应用
US7741099B2 (en) 2004-10-13 2010-06-22 Beth Israel Deaconess Medical Center Inc. Adenoviral vectors and uses thereof
RU2433825C2 (ru) 2004-12-06 2011-11-20 Медисинова, Инк. Способ лечения невропатической боли и связанных с ней синдромов
JP4604892B2 (ja) 2005-07-15 2011-01-05 船井電機株式会社 情報記録/再生装置
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
CA2717656A1 (en) 2007-02-23 2008-08-28 Baylor Research Institute Activation of human antigen-presenting cells through clec-6
JP5779090B2 (ja) 2008-04-09 2015-09-16 マックスサイト インコーポレーティッド 新規に単離された細胞の治療組成物の操作および送達
DK2539436T3 (da) * 2010-02-25 2021-10-18 Abt Holding Co Modulering af makrofagaktivering
JP5975983B2 (ja) * 2010-04-16 2016-08-23 ベリカム ファーマシューティカルズ, インコーポレイテッド 固形腫瘍を処置するための方法
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
JP6053688B2 (ja) * 2011-10-07 2016-12-27 国立大学法人三重大学 キメラ抗原受容体
JP6021617B2 (ja) 2012-12-05 2016-11-09 カンタツ株式会社 撮像レンズ
US9221908B2 (en) * 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
WO2014130635A1 (en) * 2013-02-20 2014-08-28 Novartis Ag Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
US20160145348A1 (en) 2013-03-14 2016-05-26 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
DE102013215794A1 (de) 2013-08-09 2015-02-12 Krones Ag Vorrichtung und Verfahren zum Ausrichten von unrunden Behältern
GB201315036D0 (en) 2013-08-22 2013-10-02 Renishaw Plc Apparatus and method for building objects by selective solidification of powder material
DK3186284T3 (da) 2014-08-28 2022-05-09 Bioatla Inc Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
CN107708710A (zh) 2015-03-17 2018-02-16 嵌合体生物工程公司 Smart CAR装置,DE CAR多肽,Side CAR及其使用
EP3288569A4 (en) 2015-04-29 2018-12-19 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
CN104829733B (zh) 2015-05-25 2018-06-05 广州百暨基因科技有限公司 抗原结合单元稳定的嵌合抗原受体及制备方法与应用
GB201509413D0 (en) 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
US20170216354A1 (en) 2015-06-12 2017-08-03 Batu Biologics, Inc. Clinically useful non-antigen pulsed dendritic cells
JP7032304B2 (ja) * 2015-07-28 2022-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア キメラ抗原受容体を発現する改変された単球/マクロファージおよびその使用
EP3334764A2 (en) * 2015-10-13 2018-06-20 Brigham Young University Macrophage chimeric antigen receptor (moto-car) in imunotherapy
EP4161536A4 (en) * 2020-06-04 2024-08-14 Carisma Therapeutics Inc. Novel constructs for chimeric antigen receptors

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