EA202190624A1 - Car-экспрессирующие т-клетки и car-экспрессирующий вектор - Google Patents

Car-экспрессирующие т-клетки и car-экспрессирующий вектор

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Publication number
EA202190624A1
EA202190624A1 EA202190624A EA202190624A EA202190624A1 EA 202190624 A1 EA202190624 A1 EA 202190624A1 EA 202190624 A EA202190624 A EA 202190624A EA 202190624 A EA202190624 A EA 202190624A EA 202190624 A1 EA202190624 A1 EA 202190624A1
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Eurasian Patent Office
Prior art keywords
car
expressing
cells
interleukin
vector
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EA202190624A
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English (en)
Inventor
Тихиро Таке
Такаюки Татамия
Акико Ямагути
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Нойл-Иммьюн Байотек, Инк.
Такеда Фармасьютикал Компани Лимитед
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Application filed by Нойл-Иммьюн Байотек, Инк., Такеда Фармасьютикал Компани Лимитед filed Critical Нойл-Иммьюн Байотек, Инк.
Publication of EA202190624A1 publication Critical patent/EA202190624A1/ru

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Abstract

Настоящее изобретение относится к иммунным клеткам (таким как CAR-T-клетки), имеющим более высокую противоопухолевую активность, чем иммунные клетки (такие как CAR-T-клетки), экспрессирующие только CAR (не экспрессирующие цитокины и/или хемокины). В одном из своих аспектов настоящее изобретение относится к T-клетке, которая экспрессирует (1) химерный антигенный рецептор (CAR), (2) по меньшей мере один цитокин, выбранный из группы, состоящей из интерлейкина-15 (IL-15), интерлейкина-18 (IL-18), интерлейкина-21 (IL-21) и интерлейкина-27 (IL-27) и (3) лиганд хемокина CC 19 (CCL19).
EA202190624A 2018-08-31 2019-08-30 Car-экспрессирующие т-клетки и car-экспрессирующий вектор EA202190624A1 (ru)

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JP2018163310 2018-08-31
PCT/JP2019/034055 WO2020045610A1 (ja) 2018-08-31 2019-08-30 Ｃａｒ発現ｔ細胞及びｃａｒ発現ベクター

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US (1) US20210309712A1 (ru)
EP (1) EP3845654A4 (ru)
JP (1) JPWO2020045610A1 (ru)
KR (1) KR20210053925A (ru)
CN (1) CN112771166A (ru)
AU (1) AU2019331866A1 (ru)
BR (1) BR112021003640A2 (ru)
CA (1) CA3111170A1 (ru)
CO (1) CO2021003508A2 (ru)
EA (1) EA202190624A1 (ru)
IL (1) IL281013A (ru)
MX (1) MX2021002373A (ru)
SG (1) SG11202101930XA (ru)
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