CO2021003508A2 - Células t que expresan car y vector de expresión de car - Google Patents

Células t que expresan car y vector de expresión de car

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Publication number
CO2021003508A2
CO2021003508A2 CONC2021/0003508A CO2021003508A CO2021003508A2 CO 2021003508 A2 CO2021003508 A2 CO 2021003508A2 CO 2021003508 A CO2021003508 A CO 2021003508A CO 2021003508 A2 CO2021003508 A2 CO 2021003508A2
Authority
CO
Colombia
Prior art keywords
car
interleukin
expression vector
cells expressing
cells
Prior art date
Application number
CONC2021/0003508A
Other languages
English (en)
Inventor
Chihiro TAKE
Takayuki Tatamiya
Akiko Yamaguchi
Original Assignee
Takeda Pharmaceuticals Co
Noile Immune Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co, Noile Immune Biotech Inc filed Critical Takeda Pharmaceuticals Co
Publication of CO2021003508A2 publication Critical patent/CO2021003508A2/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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Abstract

RESUMEN La presente invención proporciona células inmunes (tales como las células T-CAR) que tienen mayor actividad antitumoral que las células inmunes (tales como las células CAR-T) que expresan solo un CAR (que no expresan citoquinas ni quimiocinas). Una célula T provista en un aspecto de la presente invención expresa (1) un receptor de antígeno quimérico (CAR), (2) al menos una seleccionada del grupo que consiste en interleuquina-15 (IL-15), interleuquina-18 (IL-18), interleuquina-21 (IL-21) e interleuquina-27 (IL-27), y (3) la quimiocina ligando CC 19 (CCL19).
CONC2021/0003508A 2018-08-31 2021-03-18 Células t que expresan car y vector de expresión de car CO2021003508A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018163310 2018-08-31
PCT/JP2019/034055 WO2020045610A1 (ja) 2018-08-31 2019-08-30 Ｃａｒ発現ｔ細胞及びｃａｒ発現ベクター

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CO2021003508A2 true CO2021003508A2 (es) 2021-08-09

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US (1) US20210309712A1 (es)
EP (1) EP3845654A4 (es)
JP (1) JPWO2020045610A1 (es)
KR (1) KR20210053925A (es)
CN (1) CN112771166A (es)
AU (1) AU2019331866A1 (es)
BR (1) BR112021003640A2 (es)
CA (1) CA3111170A1 (es)
CO (1) CO2021003508A2 (es)
EA (1) EA202190624A1 (es)
IL (1) IL281013A (es)
MX (1) MX2021002373A (es)
SG (1) SG11202101930XA (es)
TW (1) TW202016295A (es)
WO (1) WO2020045610A1 (es)

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CN111849910B (zh) 2020-05-27 2021-06-15 南京北恒生物科技有限公司 工程化免疫细胞及其用途
IL299911A (en) * 2020-08-14 2023-03-01 Kite Pharma Inc Improving immune cell function
CN112175998A (zh) * 2020-10-12 2021-01-05 广东昭泰体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其应用
CN113046320B (zh) * 2021-02-19 2023-04-14 中国医学科学院基础医学研究所 胞外段为Vδ1(GTM)Vγ4的CAR分子及表达该分子的CAR-T细胞及其用途
CN117881407A (zh) * 2021-07-09 2024-04-12 得克萨斯大学体系董事会 靶向trop-2阳性癌症的嵌合抗原受体
AU2022316980A1 (en) 2021-07-29 2024-01-25 Takeda Pharmaceutical Company Limited Car-expressing immune cells that specifically target mesothelin and uses thereof
KR20230153301A (ko) * 2022-04-27 2023-11-06 주식회사 티에스디라이프사이언스 이종 면역세포에 대한 화학주성을 유도하는 전능성 줄기세포 유래 면역세포
WO2023205868A1 (pt) * 2022-04-29 2023-11-02 Fundação Hemocentro de Ribeirão Preto Sequência de ácido nucleico que codifica um receptor de célula natural killer de antígeno quimérico (nk-car), polipeptídeo do referido nk car, vetor que compreende a referida sequência de ácido nucleico, método in vitro de obtenção de uma célula nk, uso dos referidos sequência de ácido nucleica, polipeptídeo ou vetor, e composição farmacêutica

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