CO2020012504A2 - Inmunoterapia con células car de anticuerpos biespecíficos - Google Patents

Inmunoterapia con células car de anticuerpos biespecíficos

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Publication number
CO2020012504A2
CO2020012504A2 CONC2020/0012504A CO2020012504A CO2020012504A2 CO 2020012504 A2 CO2020012504 A2 CO 2020012504A2 CO 2020012504 A CO2020012504 A CO 2020012504A CO 2020012504 A2 CO2020012504 A2 CO 2020012504A2
Authority
CO
Colombia
Prior art keywords
bispecific antibody
immune cells
cell immunotherapy
car cell
antibody car
Prior art date
Application number
CONC2020/0012504A
Other languages
English (en)
Inventor
Jianhua Yu
Michael Caligiuri
Original Assignee
Cytoimmune Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytoimmune Therapeutics Inc filed Critical Cytoimmune Therapeutics Inc
Publication of CO2020012504A2 publication Critical patent/CO2020012504A2/es

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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
    • A61K2239/13—Antibody-based
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

En la presente se describen vectores únicos que, cuando se expresan en células inmunes citolíticas, dan como resultado tanto la expresión de (1) un CAR que se dirige a antígenos asociados a tumores, como (2) la secreción de un anticuerpo biespecífico que en un extremo reconoce NKG2D expresado tanto en células inmunes innatas como en células inmunes citolíticas específicas de antígeno y, en el otro extremo, se dirige a antígenos asociados a tumores. Inesperadamente, estas modificaciones de las células T dan como resultado una mayor supervivencia y proliferación in vivo. Por lo tanto, se describen usos terapéuticos y de diagnóstico.
CONC2020/0012504A 2018-03-16 2020-10-06 Inmunoterapia con células car de anticuerpos biespecíficos CO2020012504A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862644343P 2018-03-16 2018-03-16
PCT/US2019/022639 WO2019178576A1 (en) 2018-03-16 2019-03-15 Bispecific antibody car cell immunotherapy

Publications (1)

Publication Number Publication Date
CO2020012504A2 true CO2020012504A2 (es) 2020-10-30

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US (1) US20210087275A1 (es)
EP (1) EP3765042A4 (es)
JP (1) JP7202689B2 (es)
KR (1) KR20200131844A (es)
CN (1) CN112118850A (es)
AU (1) AU2019233917A1 (es)
BR (1) BR112020018301A2 (es)
CA (1) CA3092355A1 (es)
CO (1) CO2020012504A2 (es)
IL (1) IL276975A (es)
MX (1) MX2020009475A (es)
RU (1) RU2020133311A (es)
SG (1) SG11202008129YA (es)
WO (1) WO2019178576A1 (es)

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US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
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CN113481165B (zh) * 2020-07-16 2022-06-03 山东博安生物技术股份有限公司 分泌双特异性t细胞衔接子的car-t及治疗实体肿瘤的应用
AU2021333653A1 (en) * 2020-08-25 2023-03-23 Cytoimmune Therapeutics, Inc. Bispecific antibody car cell immunotherapy
WO2022063302A1 (zh) * 2020-09-25 2022-03-31 克莱格医学有限公司 免疫细胞活性调节
US20240174768A1 (en) 2021-03-03 2024-05-30 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Bispecific antibodies enhancing cell mediated immune responses
CN117730145A (zh) * 2021-07-16 2024-03-19 克莱格医学有限公司 嵌合抗原受体
CN115286717A (zh) * 2022-09-15 2022-11-04 北京多能赛尔生物科技有限公司 一种可募集并激活nk细胞的car t细胞及应用
WO2024140980A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 表达趋化因子受体的细胞及其用途

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