KR20230073346A - 리간드 결합 활성을 조정 가능한 리간드 결합 분자 - Google Patents

리간드 결합 활성을 조정 가능한 리간드 결합 분자 Download PDF

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KR20230073346A
KR20230073346A KR1020237015916A KR20237015916A KR20230073346A KR 20230073346 A KR20230073346 A KR 20230073346A KR 1020237015916 A KR1020237015916 A KR 1020237015916A KR 20237015916 A KR20237015916 A KR 20237015916A KR 20230073346 A KR20230073346 A KR 20230073346A
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ligand
antibody
seq
binding molecule
protease
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도모유키 이가와
히로유키 이시카와
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추가이 세이야쿠 가부시키가이샤
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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KR1020237015916A 2016-11-28 2017-11-28 리간드 결합 활성을 조정 가능한 리간드 결합 분자 Ceased KR20230073346A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPJP-P-2016-229882 2016-11-28
JP2016229882 2016-11-28
KR1020197017817A KR102533814B1 (ko) 2016-11-28 2017-11-28 리간드 결합 활성을 조정 가능한 리간드 결합 분자
PCT/JP2017/042570 WO2018097308A1 (ja) 2016-11-28 2017-11-28 リガンド結合活性が調整可能なリガンド結合分子

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KR1020237015916A Ceased KR20230073346A (ko) 2016-11-28 2017-11-28 리간드 결합 활성을 조정 가능한 리간드 결합 분자

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US (2) US12060654B2 (enExample)
EP (1) EP3546480A4 (enExample)
JP (3) JP7626577B2 (enExample)
KR (2) KR102533814B1 (enExample)
CN (1) CN110214151A (enExample)
AU (1) AU2017364818C1 (enExample)
BR (1) BR112019008265A2 (enExample)
CA (1) CA3039316A1 (enExample)
IL (1) IL266827B2 (enExample)
MX (3) MX2019005947A (enExample)
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KR102533814B1 (ko) 2016-11-28 2023-05-19 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
KR20240018673A (ko) 2016-11-28 2024-02-13 추가이 세이야쿠 가부시키가이샤 항원 결합 도메인 및 운반 부분을 포함하는 폴리펩티드
TWI818934B (zh) 2017-11-28 2023-10-21 日商中外製藥股份有限公司 可調整配體結合活性的配體結合分子
JP7482630B2 (ja) 2017-11-28 2024-05-14 中外製薬株式会社 抗原結合ドメインおよび運搬部分を含むポリペプチド
EP3794022A1 (en) * 2018-05-14 2021-03-24 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
JP7414736B2 (ja) 2018-05-30 2024-01-16 中外製薬株式会社 アグリカン結合ドメインおよび運搬部分を含むポリペプチド
US20210253672A1 (en) * 2018-05-30 2021-08-19 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule containing single domain antibody
JP2021530243A (ja) * 2018-07-25 2021-11-11 アスクジーン・ファーマ・インコーポレイテッドAskGene Pharma, Inc. 新規ｉｌ−２１プロドラッグおよびそれを使用する方法
US20220048966A1 (en) * 2018-09-28 2022-02-17 Pierre Fabre Medicament New immunocytokines for the treatment of cancer
CN120022352A (zh) 2018-10-22 2025-05-23 联邦高等教育系统匹兹堡大学 Cxcr3的可切割激活剂及其使用方法
WO2020116498A1 (ja) * 2018-12-04 2020-06-11 中外製薬株式会社 Ｃｘｃｒ３リガンド
CN113905757A (zh) 2019-06-05 2022-01-07 中外制药株式会社 抗体切割位点结合分子
WO2020246567A1 (ja) * 2019-06-05 2020-12-10 中外製薬株式会社 プロテアーゼ基質、及びプロテアーゼ切断配列を含むポリペプチド
WO2020252264A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
EP4021927A1 (en) * 2019-08-29 2022-07-06 Antagonis Biotherapeutics GmbH T-cell mobilizing cxcl10 mutant with increased glycosaminoglycan binding affinity
WO2021149697A1 (en) * 2020-01-20 2021-07-29 Chugai Seiyaku Kabushiki Kaisha Ligand-binding fusion proteins
EP3889183A1 (en) * 2020-04-01 2021-10-06 Pierre Fabre Medicament A protein complex comprising an immunocytokine
EP4373862A1 (en) * 2021-07-19 2024-05-29 Chugai Seiyaku Kabushiki Kaisha Protease-mediated target specific cytokine delivery using fusion polypeptide
WO2023120643A1 (ja) 2021-12-23 2023-06-29 中外製薬株式会社 Ｃｘｃｒ３発現細胞遊走活性が増強したｃｘｃｒ３リガンド。
CN120112547A (zh) 2022-11-16 2025-06-06 瑞泽恩制药公司 包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白

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