KR20230041680A - 안구 질환 치료제로서의 trpv4 억제제 - Google Patents

안구 질환 치료제로서의 trpv4 억제제 Download PDF

Info

Publication number
KR20230041680A
KR20230041680A KR1020237000435A KR20237000435A KR20230041680A KR 20230041680 A KR20230041680 A KR 20230041680A KR 1020237000435 A KR1020237000435 A KR 1020237000435A KR 20237000435 A KR20237000435 A KR 20237000435A KR 20230041680 A KR20230041680 A KR 20230041680A
Authority
KR
South Korea
Prior art keywords
cyclopropyl
pyrimido
azepin
phenyl
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237000435A
Other languages
English (en)
Korean (ko)
Inventor
겐타로 오하라
슈조 와타나베
히데아키 하라
마사미쓰 시마자와
에이지 스가루
Original Assignee
라퀄리아 파마 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 라퀄리아 파마 인코포레이티드 filed Critical 라퀄리아 파마 인코포레이티드
Publication of KR20230041680A publication Critical patent/KR20230041680A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/30—Animals modified by surgical methods
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020237000435A 2020-07-16 2021-07-16 안구 질환 치료제로서의 trpv4 억제제 Pending KR20230041680A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052572P 2020-07-16 2020-07-16
US63/052,572 2020-07-16
PCT/JP2021/026829 WO2022014707A1 (ja) 2020-07-16 2021-07-16 眼疾患の治療薬としてのｔｒｐｖ４阻害薬

Publications (1)

Publication Number Publication Date
KR20230041680A true KR20230041680A (ko) 2023-03-24

Family

ID=79555653

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237000435A Pending KR20230041680A (ko) 2020-07-16 2021-07-16 안구 질환 치료제로서의 trpv4 억제제

Country Status (10)

Country Link
US (1) US20230255965A1 (https=)
EP (1) EP4183415A4 (https=)
JP (1) JPWO2022014707A1 (https=)
KR (1) KR20230041680A (https=)
CN (1) CN115776890A (https=)
BR (1) BR112022024553A2 (https=)
CA (1) CA3189206A1 (https=)
MX (1) MX2023000610A (https=)
TW (1) TW202216143A (https=)
WO (1) WO2022014707A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120641413A (zh) * 2023-04-18 2025-09-12 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
WO2024217446A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
WO2024217439A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
CN116726013A (zh) * 2023-04-25 2023-09-12 中国科学院大学深圳医院(光明) Gsk2193874在防治痛性糖尿病周围神经病变中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013169396A1 (en) 2012-05-11 2013-11-14 The University Of Utah Research Foundation Compounds with trpv4 activity, compositions and associated methods thereof
MX2017011166A (es) 2017-08-31 2019-03-07 Univ Mexico Nac Autonoma Uso de los farmacos antagonistas del canal ionico transient receptor potential vaniloid 4 (trpv4) para el tratamiento del edema macular.

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409125A (en) 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
DE4027320C2 (de) 1990-08-29 1993-09-30 Ursapharm Arzneimittel Gmbh Fluid-Abgabeeinrichtung für keimfreies Fluid
EP0944530A1 (en) 1996-12-09 1999-09-29 Bausch & Lomb Incorporated Single-use flexible container
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
TW586946B (en) 2000-12-22 2004-05-11 Novartis Ag Process to improve stability
US20080139648A1 (en) 2004-12-09 2008-06-12 Santen Pharmaceutical Co., Ltd. Product Containing Prostaglandin Having Fluorine Atom In Its Molecule
WO2007082262A2 (en) 2006-01-11 2007-07-19 Smithkline Beecham Corporation Novel compounds
JP2009527495A (ja) 2006-02-17 2009-07-30 スミスクライン・ビーチャム・コーポレイション 新規化合物
JP5294601B2 (ja) 2007-09-28 2013-09-18 小林製薬株式会社 Ｔｒｐｖ４受容体抑制剤
WO2009111680A1 (en) 2008-03-07 2009-09-11 Smithline Beecham Corporation Trpv4 antagonists
WO2009146182A1 (en) 2008-04-18 2009-12-03 Smithkline Beecham Corporation Trpv4 antagonists
WO2009146177A1 (en) 2008-04-18 2009-12-03 Smithkline Beecham Corporation Trpv4 antagonists
WO2009139239A1 (ja) * 2008-05-14 2009-11-19 日本電気株式会社 窒化物半導体レーザ及びその製造方法
WO2010011912A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Trpv4 antagonists
JP5607046B2 (ja) 2008-07-25 2014-10-15 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｔｒｐｖ４拮抗薬
WO2011091407A1 (en) 2010-01-25 2011-07-28 Glaxosmithkline Llp Trpv4 antagonists
WO2011091410A1 (en) 2010-01-25 2011-07-28 Glaxos Smithkline Llc Trpv4 antagonists
WO2011119694A1 (en) 2010-03-23 2011-09-29 Glaxosmithkline Llc Trpv4 antagonists
WO2011119693A1 (en) 2010-03-23 2011-09-29 Glaxosmithkline Llc Trpv4 antagonists
WO2011119704A1 (en) * 2010-03-23 2011-09-29 Glaxosmithkline Llc Trpv4 antagonists
WO2011119701A1 (en) 2010-03-23 2011-09-29 Glaxosmithkline Llc Trpv4 antagonists
WO2012144661A1 (en) 2011-04-20 2012-10-26 Shionogi & Co., Ltd. Aromatic heterocyclic derivative having trpv4-inhibiting activity
JO3154B1 (ar) 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
EP2720546B1 (en) 2011-06-17 2016-04-06 Glaxosmithkline Intellectual Property (No. 2) Limited Spiro-cyclic trpv4 antagonists
US8927585B2 (en) 2011-06-17 2015-01-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonists
WO2013146754A1 (ja) 2012-03-27 2013-10-03 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素５員環誘導体
WO2015046193A1 (ja) 2013-09-25 2015-04-02 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体
WO2015199206A1 (ja) 2014-06-27 2015-12-30 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する６員環誘導体
CN109153672B (zh) 2016-05-19 2021-12-07 葛兰素史密斯克莱知识产权（第2 号）有限公司 Trpv4拮抗剂
RU2019110821A (ru) 2016-09-20 2020-10-22 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Антагонисты trpv4
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
JP2019532054A (ja) 2016-09-20 2019-11-07 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｔｒｐｖ４拮抗薬
JP7195067B2 (ja) 2018-06-20 2022-12-23 花王株式会社 ロズマリン酸誘導体又はその塩
WO2021170811A1 (en) * 2020-02-27 2021-09-02 Glaxosmithkline Intellectual Property (No.2) Limited Method of treating eye disease using trpv4 antagonists
JP7692219B2 (ja) * 2020-04-30 2025-06-13 ラクオリア創薬株式会社 Ｔｒｐｖ４拮抗薬としてのピリミジン－４（３ｈ）－オン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013169396A1 (en) 2012-05-11 2013-11-14 The University Of Utah Research Foundation Compounds with trpv4 activity, compositions and associated methods thereof
MX2017011166A (es) 2017-08-31 2019-03-07 Univ Mexico Nac Autonoma Uso de los farmacos antagonistas del canal ionico transient receptor potential vaniloid 4 (trpv4) para el tratamiento del edema macular.

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Exp Eye Res, 2011, 93: 710-719
Handbook of Experimental Pharmacology; Transient Receptor Potential (TRP) Channels, 2007, 179: 189-205
Int J Biochem Cell Biol, 2016, 78: 217-228
J Neurosci, 2011, 31: 7089-7101
Ophthalmology, 2010, 117: 313-319
Pflugers Arch, 2005, 451: 1-10
Pharmacol Ther, 2017, 177: 9-22
PLoS ONE, 2019, 14(5): e0212158
Prog Retin Eye Res, 2009, 28: 423-451
RETINA, 2018, 38: 272-282
Survey of ophthalmology, 2018, 63: 816-850

Also Published As

Publication number Publication date
BR112022024553A2 (pt) 2023-01-24
TW202216143A (zh) 2022-05-01
WO2022014707A1 (ja) 2022-01-20
US20230255965A1 (en) 2023-08-17
JPWO2022014707A1 (https=) 2022-01-20
EP4183415A4 (en) 2024-07-17
MX2023000610A (es) 2023-02-13
EP4183415A1 (en) 2023-05-24
CN115776890A (zh) 2023-03-10
CA3189206A1 (en) 2022-01-20

Similar Documents

Publication Publication Date Title
KR20230041680A (ko) 안구 질환 치료제로서의 trpv4 억제제
CN113214287B (zh) Hpk1抑制剂及其使用方法
CN116209438A (zh) 使用sos1抑制剂治疗具有shp2突变的恶性疾病
CN114786777A (zh) Ras抑制剂
CN113166065A (zh) 用于治疗与nlrp活性相关的病症的化合物和组合物
EA032621B1 (ru) Индазолкарбоксамиды, способы их получения, содержащие их фармацевтические препараты и их применение для изготовления лекарственных средств
CN103429582A (zh) Mst1激酶抑制剂及其用法
CN110997674A (zh) 作为C5a抑制剂的6-5稠合环类
US20230374143A1 (en) A sortilin antagonist for use in the prevention or treatment of hearing loss
CN107849044B (zh) 作为ddr1抑制剂的三氮杂-螺癸酮类化合物
WO2024140850A1 (zh) 一种蛋白酪氨酸激酶抑制剂及其医药用途
JP2025516358A (ja) テトラヒドロイソキノリンヘテロ二官能性ｂｃｌ－ｘｌ分解剤
WO2025076285A1 (en) Compounds, pharmaceutical compositions thereof, and methods of using the same
US20220267306A1 (en) Heterocyclic prolinamide derivatives
US20250288683A1 (en) Tetrahydroisoquinoline heterobifunctional bcl-xl degraders
CN108699105A (zh) 作为htra1抑制剂的新型二氟酮酰胺衍生物
JP7808733B2 (ja) 置換オキソイソインドリニルピペリジン－２，６－ジオン化合物
HK40092802A (en) Trpv4 inhibitor as therapeutic drug for eye disease
WO2024165469A1 (en) Combinations of dgk (diacylglycerol kinase) inhibitors and immune checkpoint inhibitors and modulators
HK40085364A (en) Trpv4 inhibitor as therapeutic drug for eye disease
WO2006132192A1 (ja) 新規２－キノロン誘導体
RU2780338C2 (ru) 6-5 КОНДЕНСИРОВАННЫЕ КОЛЬЦА КАК ИНГИБИТОРЫ С5а
WO2025108404A1 (zh) 一种靶向降解雄激素受体的双功能嵌合体的杂环化合物及其用途
HK40128268A (zh) Ras抑制剂
HK40076674A (en) Ras inhibitors

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20230104

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20240716

Comment text: Request for Examination of Application